A5036951696- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Metabolism and Genetic Disorders
- Free Radicals and Antioxidants
- Paraoxonase enzyme and polymorphisms
- Porphyrin and Phthalocyanine Chemistry
- Pancreatitis Pathology and Treatment
- Natural product bioactivities and synthesis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipoproteins and Cardiovascular Health
- Enzyme function and inhibition
- Antioxidant Activity and Oxidative Stress
- Cholinesterase and Neurodegenerative Diseases
- Erythrocyte Function and Pathophysiology
- Platelet Disorders and Treatments
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Metal-Catalyzed Oxygenation Mechanisms
- Vitamin C and Antioxidants Research
- Neonatal Respiratory Health Research
- Adipokines, Inflammation, and Metabolic Diseases
- Research on Leishmaniasis Studies
- Hemoglobin structure and function
Karadeniz Technical University
2004-2024
We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on serum lipid profiles lipoprotein (a) in 64 children with epilepsy (aged between 1 15 years) admitted child neurology outpatient clinic July 2000 2002. The were separated as group (18 children), treated 5 mg/kg/day; 2 (22 10 3 (24 sodium valproate, 20 mg/kg/day. Plasma (a), total cholesterol, triglycerides, low-density high-density apolipoprotein A B levels, liver enzymes alanine aminotransferase,...
Background: Primula vulgaris has been used in traditional treatment, and its biological functions are attributed to polyphenolics content. Objectives: The aim of this study was determine the phenolics composition antioxidant activity water extract P. (WEP) probable preventive effects against H2O2-induced DNA damage human fibroblast cells. Methods: total polyphenolic content (TPC), ferric reducing power (FRAP), radical scavenging WEP were determined using spectrophotometric methods. Phenolic...
Quinoline‐fused Zn II ( ZnPc p /ZnPc np ) and Mg MgPc /MgPc phthalocyanines with four 4‐methylquinolin‐2‐ol 1 at non‐peripheral or peripheral positions of the phthalocyanine core have been synthesized via cyclotetramerization phthalonitrile derivatives CN /CN in presence zinc (II) magnesium metal ions this study. After synthesis characterization processes, anti‐cholinesterase, anti‐α‐glucosidase, DNA nuclease, antioxidant activities, silico calculations both were investigated. The inhibitory...
Antiepileptic drugs may alter plasma lipid status in epileptic patients. We conducted a study to assess the effect of phenobarbital, carbamazepine, and valproate on levels lipoprotein (a), total cholesterol, triglycerides, low-density high-density apolipoprotein A, B 22 children. The children were separated as group 1, seven children, mean age 1.6 ± 0.2 years, treated with 5 mg/kg/day, twice daily; 2, 9.8 1.2 20 3, eight 6.8 0.6 valproate, daily. Plasma (a) other studied before...
Background. Methotrexate (MTX), a folate antagonist, is commonly used in the treatment of many different types cancer and inflammatory diseases, including pancreatic cancer, although its side effects on pancreas have not yet been researched. The mechanism MTX-induced toxicity well known, it has reported high-dose studies that sensitive to toxic effects.Objectives. aim our study was determine whether adalimumab (ADA) preventive effect rats.Material Methods. rats were equally randomly divided...
Background: Primula vulgaris has been used in traditional treatment, and its biological functions are attributed to polyphenolics content. Objectives: The aim of this study was determine the phenolics composition antioxidant activity water extract P. (WEP) probable preventive effects against H2O2-induced DNA damage human fibroblast cells. Methods: total polyphenolic content (TPC), ferric reducing power (FRAP), radical scavenging WEP were determined using spectrophotometric methods. Phenolic...
We measured lipid peroxidation and antioxidant enzymes in erythrocytes of types IIb IV hyperlipoproteinemic (HLP) human subjects comparison with age-matched controls. Thiobarbituric acid-reactive substances (TBARS), a measure peroxidation, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), reductase (GR), catalase (CAT) were determined erythrocytes. also parameters including triglycerides (TG), total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), apolipoprotein...
In this study, 4‐{2‐(2‐thienyl)ethoxy}phthalonitrile ( 3 ) and its tetra substituted peripherally metal‐free 4 ), lead (II) 5 magnesium 6 cobalt 7 phthalocyanines were synthesized. The structural characterization of the obtained compounds was performed by a combination FTIR, 1 H‐NMR, UV–vis, MALDI‐TOF techniques. inhibitory properties these determined using Ingkaninan's methods against cholinesterase enzymes. Compound had highest enzyme effect toward AChE BuChE enzymes with IC 50 values...
This study describes the constituents of phenolic acids, volatile components, antioxidant and antimicrobial activities Teucrium orientale var. glabrescens. Antioxidant activity methanolic aquous extracts were examined by three different methods, namely ferric reducing power, cupric capacity 2,2-diphenylpicrylhydrazyl radical scavenging activity. The also determined reverse phase-high performance liquid chromatography. Solid phase microextraction glabrescens was analyzed Gas...
High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the risk of coronary artery disease (CAD). Alterations in HDL-C subclass distribution and HDL-associated enzyme activities may be more important than total HDL for progression CAD. We intended investigate relationship with CAD.Our study included 101 patients stable disease, 64 healthy subjects. Serum lipoprotein-associated-phospholipase A2 (HDL-LpPLA2), paraoxonase 1 (PON1), subfraction were measured. found...
Erythrocyte membranes regulate many enzyme activities, including carbonic anhydrase II (CA II). Membrane fluidity is associated with alterations in protein function and protein-protein interactions.The purpose of this study was to show the human CA (hCA II) activity regulation by erythrocyte from diabetic hypercholesterolemic subjects.Erythrocyte were obtained diabetic, hypercholesterolemic, healthy subjects. hCA measured using electrometric method.hCA increased vitro both patients,...
Barbarea genus has been presented about 12 species, 9 taxon are endemic, in Turkey. In this sudy, enzyme inhibition was carried out on methanolic extract, chloroform ethyl acetate and the remaining aqueous phases from aerial parts of B. auriculata var paludosa, integrifolia, plantaginea species HPLC studies were their extract present study for first time. Phenolic compounds determined using reverse phase-high performance liquid chromatography (RP-HPLC). p-OH benzoic acid, vanilic...
The aim of the present study is to determine potent biological activities and carry out isolation studies on Barbarea integrifolia. antioxidant capacity species was evaluated by total phenolic content, FRAP, CUPRAC, DPPH radical scavenging activity. Anticancer activity were performed MTT assay in MDA-MB-231, MCF-7, Hep3B, PC-3, A549, HCT116, L-929 cell lines. It observed that remaining aqueous fraction has higher content while CUPRAC FRAP assays displayed for methanolic extract chloroform...
Behçet's disease is a chronic multisystemic disorder. It characterized by relapsing systemic inflammatory process. Thrombosis one of the vascular manifestations and closely affected endothelial dysfunction resulting from degree perivascular The present study was carried out to determine if plasma PMN elastase may be good marker for evaluation status in patients who are active inactive phases. parameters including elastase, t-PA, PAI-1 other markers related activity such as ESR, leukocyte...