A5023528765- Neurotransmitter Receptor Influence on Behavior
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Hemispheric Asymmetry in Neuroscience
- Autism Spectrum Disorder Research
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Genetic Associations and Epidemiology
- Hormonal and reproductive studies
- Ion channel regulation and function
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Aluminum toxicity and tolerance in plants and animals
- RNA Interference and Gene Delivery
- Cognitive Abilities and Testing
- Genomics and Rare Diseases
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Morphological variations and asymmetry
- Malaria Research and Control
Sorbonne Université
1996-2023
Institut du Fer à Moulin
2014-2023
Inserm
2011-2023
Centre National de la Recherche Scientifique
1991-2016
Institut de Biologie Paris-Seine
2016
Neurosciences Paris-Seine
2016
FHU Neurovasc
2012
Institut National de Recherche en Santé Publique
2011
Université Paris-Est Créteil
2001-2007
Université Paris Cité
1990-2005
Behavioral and biochemical studies suggest that dopamine (DA) plays a role in the reinforcing addictive properties of drugs abuse. Recently, this hypothesis has been challenged on basis observation that, mice genetically lacking plasma membrane transporter [DAT-knock out (DAT-KO)], cocaine maintained its being self-administered inducing place preference, despite failure to increase extracellular dorsal striatum. Here we report DAT-KO mice, amphetamine dialysate medial part nucleus accumbens....
Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, some cases, lateral ventricle enlargement. In vitro studies showed that ophn1 regulates dendritic spine through the control Rho GTPases, but its vivo remains unknown. We generated a mouse model deficiency and it mimics ventricles enlargement without affecting cerebellum morphoanatomy. The knock-out mice exhibit behavioral defects spatial memory together impairment...
In all experimental mammals tested (rats, dogs, primates), intramuscular injections of the oil-soluble antimalarial artemisinin derivatives artemether and arteether have produced an unusual pattern selective damage to brain stem centers predominantly involved in auditory processing vestibular reflexes. Artesunate, most widely used these compounds, is a water soluble hemisuccinate derivative given parenterally either by intravenous or injection. The neurotoxic potential parenteral artesunate...
Intramuscular injections of high doses the oil-soluble antimalarial artemisinin derivatives artemether and arteether produce an unusual pattern selective damage to brain stem centers in experimental mammals, predominantly those involved auditory processing vestibular reflexes. We have shown recently adult Swiss albino mice that parenteral artesunate, a water-soluble derivative, is significantly less neurotoxic than intramuscular this murine model. Using same model, which drugs were...
Patients with Doublecortin (DCX) mutations have severe cortical malformations associated mental retardation and epilepsy. Dcx knockout (KO) mice show no major isocortical abnormalities, but discrete hippocampal defects. We questioned the functional consequences of these defects report here that KO are hyperactive exhibit spontaneous convulsive seizures. Changes in neuropeptide Y calbindin expression, consistent seizure occurrence, were detected a large proportion animals, convulsants,...
Insulin-like growth factors control numerous processes, namely somatic growth, metabolism and stress resistance, connecting this pathway to aging age-related diseases. factor signaling also impacts on neurogenesis, neuronal survival structural plasticity. Recent reports demonstrated that diminished insulin-like confers increased resistance in brain other tissues. To better understand the role of neuroprotection, we inactivated type-1-receptor forebrain neurons using conditional...
Abstract The dopamine transporter (DAT) plays a critical role in calibrating the duration and intensity of (DA) neurotransmission. Mice which DAT gene has been genetically deleted exhibit constitutively high levels extrasynaptic DA spontaneous hyperactivity. Numerous studies have characterized adaptive molecular, physiological, behavioural consequences abnormal neurotransmission these mice. In order to determine genetic background contribution phenotypes, mutation was transferred on...
ABSTRACT The surface glycoprotein, Thy-1, when expressed by transfection in NG115/401L neural cells, inhibits their neurite outgrowth over astrocytes. We have investigated the role of glycosylphosphatidylinositol anchor Thy-1 this inhibition. Hybrid molecules, which lipid was replaced polypeptide transmembrane domains, were transfection. Lines expressing with and full cytoplasmic domains NCAM-140, or truncated domain CD8, not inhibited ability to extend neurites Truncation cyto-plasmic...
Aberrant membrane localization of dopamine D 1 receptor (D1R) is associated with l -DOPA-induced dyskinesia (LID), a major complication -DOPA treatment in Parkinson's disease (PD). Since the proteasome plays central role modulating neuronal response through regulation neurotransmitter intraneuronal fate, we hypothesized that ubiquitine-proteasome proteolytic pathway could be impaired LID. Those LIDs are actually striatum-specific decrease catalytic activity and accumulation polyubiquitinated...
Morphine is endogenously synthesized in the central nervous system and endogenous dopamine thought to be necessary for morphine formation. As Parkinson's disease results from loss of associated with pain, we considered how regulated untreated l-DOPA-treated parkinsonian brain. However, as cellular origin overall distribution remains obscure pathological adult brain, first characterized morphine-like compound immunoreactive cells rat striatum. We then studied changes immunoreactivity medium...
In rat prefrontal cortex (PFC), long-term depression induced by low-frequency single stimuli has never been studied. Combined with the well-documented involvement of dopamine transporters (DATs) in regulation PFC-dependent cognitive processes, it is important to test whether this form plasticity can be modulated DAT activity PFC. Here, we show first that prolonged 3-Hz successfully synaptic PFC slices whose induction depended on endogenous stimulation D1-like and D2-like receptors activation...