A5021274784- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Pneumonia and Respiratory Infections
- Viral Infections and Immunology Research
- Bacterial Identification and Susceptibility Testing
- Urinary Tract Infections Management
- Parvovirus B19 Infection Studies
- Neuroscience of respiration and sleep
- Pediatric Urology and Nephrology Studies
- Advanced biosensing and bioanalysis techniques
- Antifungal resistance and susceptibility
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Central Venous Catheters and Hemodialysis
- RNA and protein synthesis mechanisms
- Enterobacteriaceae and Cronobacter Research
- Infectious Encephalopathies and Encephalitis
- Streptococcal Infections and Treatments
- Restraint-Related Deaths
- Infant Health and Development
- Fungal Infections and Studies
- Amoebic Infections and Treatments
- Bacterial Infections and Vaccines
- Otolaryngology and Infectious Diseases
Edmond and Lily Safra Children's Hospital
2019-2024
Sheba Medical Center
2019-2024
Israel Ministry of Health
2024
Tel Aviv University
2013-2024
Rabin Medical Center
2019
El Paso County Public Health
2019
Hillel Yaffe Medical Center
2017
Carmel (Israel)
2015
Ben-Gurion University of the Negev
2013
University Medical Center
2013
Bacterial and viral infections are often clinically indistinguishable, leading to inappropriate patient management antibiotic misuse. Bacterial-induced host proteins such as procalcitonin, C-reactive protein (CRP), Interleukin-6, routinely used support diagnosis of infection. However, their performance is negatively affected by inter-patient variability, including time from symptom onset, clinical syndrome, pathogens. Our aim was identify novel viral-induced that can complement...
This study presents an analysis of the epidemiological trends parvovirus B19 (B19V) in Israel from 2010 to 2023, with particular emphasis on outbreak 2023. The utilized molecular diagnostic data individual patients obtained at Central Virology Laboratory. Between and 2022, 8.5% PCR-tested samples were positive for B19V, whereas this percentage surged 31% samples. Throughout period, annual cycles consistently peaked early spring/summer, most recent prominent occurring 2016. Predominantly,...
Public health experts emphasize the need for quick, point-of-care SARS-CoV-2 detection as an effective strategy controlling virus spread. To this end, many "antigen" devices were developed and commercialized. These are mostly based on detecting SARS-CoV-2's nucleocapsid protein. Recently, alerts issued by both FDA CDC raised concerns regarding devices' tendency to exhibit false positive results. In work, we a novel alternative spike-based antigen assay, comprising four high-affinity,...
Horizontal acquisition of mobile genetic elements is a powerful evolutionary driving force that can profoundly affect pathogens epidemiology and their interactions with the environment host. In last decade, role epidemic megaplasmid, pESI was demonstrated in global emergence multi-drug resistant (MDR) Salmonella enterica serovar Infantis strains, but it unknown if this one-time phenomenon, or drive other pathogens.Epidemiological, molecular, whole genome sequencing, de-novo assembly,...
Microbiological diagnosis is central for adequate treatment of bone and joint infections. Culture-based methods have a limited diagnostic sensitivity long turnaround time (TAT). The objective this study was to compare the performance BioFire Joint Infection Panel Investigational Use Only version (hereafter BioFire)-a sample-to-result multiplex PCR panel-with culture-based 16S ribosomal RNA (rRNA) sequencing, when available.This presents retrospective analysis prospective validation panel....
Abstract Objective: To assess the validity of Antigen rapid diagnostic tests (Ag-RDT) for SARS-CoV-2 as decision support tool in various hospital-based clinical settings. Design: Retrospective cohort study among symptomatic and asymptomatic patients Healthcare workers (HCW). Setting: A large tertiary teaching medical center serving a major COVID-19 hospitalizing facility. Participants Methods: Ag-RDTs’ performance was assessed three settings: 1. Symptomatic HCW presenting at Emergency...
This report describes an unusual surge of West Nile fever in Israel June 2024, during which 125 cases were diagnosed, compared with 4 on average previous years (2014–23). Of the cases, 64 (62.1%) had neuroinvasive disease and 12 (9.6%) died; 2024 case fatality rate was not significantly elevated vs 2014–23. The early rise could be related to a temperature increase spring summer 2024.
During July-September 2022, 14 children suffering from meningoencephalitis tested positive for Coxsackievirus B2 (8 cerebrospinal fluid, 9 stool samples). Mean age 22 months (range 0-60 months); 8 were males. Seven of the presented with ataxia and 2 had imaging features rhombencephalitis, not previously described in association B2.
Abstract Background Several uses of Antigen rapid diagnostic tests (Ag-RDT) have been suggested. Analytical studies reported high specificity yet with lower sensitivity for detecting SARS-CoV-2 compared to qRT-PCR. Here, we present the use these as a decision support tool in several settings. Methods Samples were collected both Ag-RDT and qRT-PCR three different clinical settings; 1. Symptomatic patients presenting at Emergency Departments 2. Asymptomatic screened upon hospitalization 3....
Objective: This study aimed to describe the distribution of respiratory pathogens and occurrence co-pathogens during first year COVID-19 pandemic.MethodsWe used a multiplex polymerase chain reaction (PCR) panel targeting 23 microorganisms analyze oro-pharyngeal samples patients admitted our hospital with acute infection (ARI) between March 1, 2020, February 28, 2021. We matched 40 50 who were SARS-CoV-2 positive negative per month for age sex.ResultsA total 939 PCR test results included in...
Background: The Flavobacteriaceae family includes rare pathogens in children; Chryseobacterium indologenes and Elizabethkingia meningosepticum are the most common pathogenic species, with a wide range of clinical presentations high mortality rate. Although rare, diagnosis is important due to inherent resistance multiple antibiotics, especially those typically prescribed for empiric treatment aerobic Gram-negative bacterial infections. Methods: A multicenter retrospective study conducted 5...
There are limited data concerning the immunogenicity and reactogenicity of COVID-19 vaccines in children. A total 110 children, 5-11 years old were vaccinated with two doses (with a 3-week interval between doses) Pfizer-BioNTech vaccine followed for 21, 90, 180 days after vaccination immunogenicity, adverse events, breakthrough infections. Ninety first dose, GeoMean (CI 95%) IgG ascended to 1291.0 BAU (929.6-1790.2) uninfected children 1670.0 (1131.0-2466.0) Infected One hundred eighty...
Candida lusitaniae fungemia is a serious infection that rarely reported in children. The aim of this study to describe case series C. and review previous publications regarding rare pathogen. This multicenter children diagnosed with fungemia. A total 18 cases occurred over 15-year period five tertiary hospitals were included. Additionally, the literature was performed. enrolled; 11/18 (61%) males, mean age 2.3 years. All patients had severe underlying diseases risk factors for opportunistic...
Abstract This study evaluated the epidemiological and clinical characteristics of human metapneumovirus (hMPV) infection among hospitalized patients with acute respiratory infections during 2015–2021 assessed impact coronavirus disease 2019 pandemic on hMPV infection. A single‐center, retrospective cohort was performed, including pediatric adult laboratory‐confirmed hMPV. Of a total 990 patients, 253 (25.6%), 105 (10.6%), 121 (12.2%), 511 (51.6%) belonged to age groups 0–2, 3–17, 18–59, ≥60...
ABSTRACT Coxsackievirus B2 (CVB2) is a member of the enterovirus group known to induce spectrum illnesses, from mild severe. In summer 2022, an unusual outbreak enteroviral central nervous system (CNS) infections occurred that was attributed CVB2. Cerebrospinal fluid (CSF) samples collected patients in 2015–2022 were tested for via RT‐PCR, followed by Sanger sequencing positive cases. CVB2 further sequenced P1 region using NGS. A total 30 CSF identified as CVB2, with 60% these cases...
Sudden Infant Death Syndrome (SIDS) is one of the leading causes postneonatal mortality infants in most developed countries. This paper presents data on terminology and study SIDS countries, also examines problems diagnostic Russia comparison with results own researches, analyzes risk factors, which are universal as for SIDS, perinatal infant death general. The large variability diagnosis suggests that this often does not comply international standard: post-mortem examination...
Abstract Public health experts emphasize the need for quick, point-of-care SARS-CoV-2 detection as an effective strategy controlling virus spread. To this end, many “antigen” devices were developed and commercialized. These are mostly based on detecting SARS-CoV-2’s nucleocapsid protein. Recently, alerts issued by both FDA CDC raised concerns regarding devices’ tendency to exhibit false positive results. In work we a novel alternative spike-based antigen assay, comprised of four...
A 10-year-old girl with relapsed acute lymphoblastic leukemia underwent allogeneic hematopoietic stem cell transplantation. She was conditioned total body irradiation, etoposide, and anti-thymocyte globulin. On day +4, mild erythema tenderness appeared on her left big toe. Broad spectrum antibiotics were administered. However, by +7 the toe became dark red extremely painful (Panel A), patient febrile. skin biopsy performed cultures yielded a mold fungus hyaline septate hyphae staining...