A5081395708- Cerebral Venous Sinus Thrombosis
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Attention Deficit Hyperactivity Disorder
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Cerebrovascular and Carotid Artery Diseases
- Tuberous Sclerosis Complex Research
- Ophthalmology and Eye Disorders
- Bipolar Disorder and Treatment
- Polyomavirus and related diseases
- Acute Ischemic Stroke Management
- Moyamoya disease diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Autism Spectrum Disorder Research
- Vascular Malformations and Hemangiomas
- Venous Thromboembolism Diagnosis and Management
- Spinal Dysraphism and Malformations
- Olfactory and Sensory Function Studies
- Fetal and Pediatric Neurological Disorders
- Peripheral Artery Disease Management
- Vascular Procedures and Complications
- Histiocytic Disorders and Treatments
- Myasthenia Gravis and Thymoma
MSD (Australia)
2025
Cambridge University Hospitals NHS Foundation Trust
2007-2024
Addenbrooke's Hospital
2012-2023
University of California, San Francisco
2022
La Jolla Bioengineering Institute
2022
Itasca Consultants (United States)
2020
Takeda (United States)
2012-2014
University of Cambridge
2004-2013
Royal Hallamshire Hospital
2010
Sheffield Teaching Hospitals NHS Foundation Trust
2010
Tuberous sclerosis is one of the few established medical causes autism spectrum disorder and a unique neurogenetic model for testing theories about brain basis syndrome. We conducted retrospective case study neuro‐epileptic risk factors predisposing to in individuals with tuberous test current neurobiological disorder. found that an diagnosis was associated presence cortical tubers temporal but not other lobes brain. Indeed, appeared be necessary sufficient factor development However,...
<h3>Aims</h3> The Tuberous Sclerosis 2000 Study is the first comprehensive longitudinal study of tuberous sclerosis (TS) and aims to identify factors that determine prognosis. Mode presentation findings at initial assessments are reported here. <h3>Methods</h3> Children aged 0–16 years newly diagnosed with TS in UK were evaluated. <h3>Results</h3> 125 children studied. 114 (91%) met clinical criteria for a definite diagnosis remaining 11 (9%) had pathogenic <i>TSC1</i> or <i>TSC2</i>...
This study evaluated the efficacy and safety of lisdexamfetamine dimesylate (LDX) compared with placebo in children adolescents attention-deficit/hyperactivity disorder (ADHD) Europe. Osmotic-release oral system methylphenidate (OROS-MPH) was included as a reference arm. Patients (6-17 years old) baseline ADHD Rating Scale version IV (ADHD-RS-IV) total score ≥ 28 were randomized (1:1:1) to dose-optimized LDX (30, 50, or 70 mg/day), OROS-MPH (18, 36, 54 mg/day) for 7 weeks. Primary key...
Venous sinus disease must be excluded before diagnosing idiopathic intracranial hypertension but is found only rarely in typical cases. Magnetic resonance venography (MRV) the technique of choice for investigating this, and provides images that are diagnostic easy to interpret. However, recent work using more invasive techniques has documented pressure gradients stenoses lateral venous sinuses many cases hypertension.To examine reason this discrepancy establish whether there characteristic...
There is debate about the role of venous outflow obstruction in etiology idiopathic intracranial hypertension (IIH). Patients with IIH frequently have high pressures superior sagittal sinus proximal to stenotic lesions lateral sinuses that could be cause raised pressure.1,2⇓ Contrary this, it has been shown reducing pressure by withdrawing CSF reduces intrasinus pressures, implying stenoses are a secondary phenomenon.3 Meanwhile treated successfully stenting sinuses.4,5⇓ So issue unresolved....
The aim of this study was to compare the efficacy and safety prodrug psychostimulant lisdexamfetamine dimesylate (LDX) non-stimulant noradrenergic compound atomoxetine (ATX) in children adolescents with attention-deficit/hyperactivity disorder (ADHD) who had previously responded inadequately methylphenidate (MPH). This 9-week, head-to-head, randomized, double-blind, active-controlled (SPD489-317; ClinicalTrials.gov NCT01106430) enrolled patients (aged 6–17 years) at least moderately...
Background Tuberous sclerosis complex (TSC) is associated with intellectual disability, but the risk pathways are poorly understood. Method The Sclerosis 2000 Study a prospective longitudinal study of natural history TSC. One hundred and twenty-five UK children age 0–16 years TSC born between January 2001 December 2006 were studied. Intelligence was assessed using standardized measures at ≥2 age. onset epilepsy, type seizure disorder, frequency duration seizures, as well response to...
While venous congestion in the peripheral vasculature has been described and accepted, intracranial remains poorly understood. The characteristics, pathophysiology, management of cerebral stasis, hypertension remain controversial, a unifying conceptual schema is absent. lymphatic systems are part complex dynamic interaction between compartments, with interplay parenchyma, veins, arteries, cerebrospinal fluid, recently characterized lymphatic-like brain. Each component contributes towards...
ObjectiveIn this phase 3 extension study, the long-term maintenance of efficacy lisdexamfetamine dimesylate (LDX) in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) was evaluated using a randomized-withdrawal study design.MethodEuropean US patients (6–17 years; N = 276) ADHD were entered into 26-week open-label trial LDX treatment. Those who completed period (n 157) randomized 1:1 to their optimized dose (30, 50, or 70 mg per day) placebo for 6-week (RWP). The...
<b>Background</b> The extent to which intracranial venous sinus obstruction contributes idiopathic hypertension (IIH) is debated. extracranial IIH virtually unexplored. This article describes an interventional approach outflow in a group of patients with severe intractable symptoms. <b>Objective</b> To describe our technique and experience styloidectomy combined jugular stenting the treatment skull base narrowing veins. <b>Methods</b> Retrospective review all styloidectomies undertaken at...
Background Decisions about government funding for new medicines often rely on statistical models to predict how long patients will live (overall survival, OS) based early trial data. This study compared the accuracy of these predictions cancer drug pembrolizumab, using preferred by pharmaceutical companies (Sponsors) and Pharmaceutical Benefits Advisory Committee (PBAC), real-world long-term follow-up (LTFU)
A pair of monozygotic male twins with tuberous sclerosis (TS) were followed between 18 months and 3 years age. Twin 25 large cortical tubers hence extensive brain involvement was moderately mentally retarded met criteria for autism. The other twin had more (n = 31) but smaller tubers. He not did meet This study provides evidence that nongenetic factors such as extent abnormality just number are important in determining phenotypic variability TS. findings also raise questions about the...
There are limited head-to-head data comparing the efficacy of long-acting amfetamine- and methylphenidate-based psychostimulants as treatments for individuals with attention-deficit hyperactivity disorder (ADHD). This post hoc analysis provides first parallel-group comparison effect lisdexamfetamine dimesylate (lisdexamfetamine) osmotic-release oral system methylphenidate (OROS-MPH) on symptoms ADHD in children adolescents.This was a randomized, double-blind, parallel-group, dose-optimized,...
Background. Recent studies suggest more favourable recovery of oculomotor nerve palsy (ONP) caused by posterior communicating artery (PComA) aneurysms with microsurgical clipping compared to endovascular coiling. We describe a consecutive series patients ONP from PComA treated or Methods. retrospectively reviewed medical records all 2005 2009 complete partial aneurysms. Results. Twenty were identified, three unruptured Two ruptured unfit for treatment and therefore excluded. Of the 18...
Though not discussed in the medical literature or considered clinical practice, there are similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) which ought to encourage exploration of a link them. The cardinal symptoms each - headache common other their multiple frequently seen both. single discriminating factor is raised pressure, evidenced IIH usually by sign papilloedema, regarded as responsible for visual can lead blindness. Some patients with IIH,...
Objective Unsuspected idiopathic intracranial hypertension (IIH) is found in a significant minority of patients attending clinics with named headache syndromes, if it specifically sought out. Chronic fatigue syndrome frequently associated headache. Could the same be true chronic fatigue? Moreover, there are striking similarities between two conditions. they related? Attempting to answer these questions, we describe results change clinical practice aimed at capturing who might have IIH....