A5101756791- Advanced Semiconductor Detectors and Materials
- Advanced biosensing and bioanalysis techniques
- DNA and Nucleic Acid Chemistry
- Semiconductor Quantum Structures and Devices
- RNA Interference and Gene Delivery
- Force Microscopy Techniques and Applications
- Computational Drug Discovery Methods
- Cellular Mechanics and Interactions
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Cholinesterase and Neurodegenerative Diseases
- Molecular Biology Techniques and Applications
- DNA Repair Mechanisms
- Thermochemical Biomass Conversion Processes
- Epigenetics and DNA Methylation
- Surface Roughness and Optical Measurements
- Advanced ceramic materials synthesis
- Subcritical and Supercritical Water Processes
- High-Velocity Impact and Material Behavior
- Dynamics and Control of Mechanical Systems
- Genomics and Phylogenetic Studies
- Superconducting and THz Device Technology
- Aquaculture disease management and microbiota
- Catalysts for Methane Reforming
- Synthesis and biological activity
Jiangsu Yanjiang Chemical Resources Development Research Institute (China)
2022-2025
Ruijin Hospital
2025
Shanghai Jiao Tong University
2025
Shanghai Ocean University
2023-2024
First Affiliated Hospital of Xinjiang Medical University
2022-2024
Xinjiang Medical University
2022-2024
Weinan Normal University
2024
Xi'an Shiyou University
2024
Soochow University
2023
Second Affiliated Hospital of Soochow University
2023
Significance Intestinal tuft cells are sentinels monitoring the luminal contents and play a critical role in type 2 immunity. In this work, Trichinella spiralis excretion–secretion extract were shown to directly induce interleukin 25 (IL-25) release from intestinal villi, evoke calcium responses cells, activate Tas2r bitter-taste receptors, whereas bitter compound salicin was IL-25. Gα-gustducin/Gβ1γ13 and/or Gαo/Gβ1γ13, Plcβ2, Ip 3 r2, Trpm5 comprise signal transduction pathways that...
Miniature inverted–repeat transposable elements (MITEs) are predicted to play important roles on genome evolution. We developed a BLASTN-based approach for de novo identification of MITEs and systematically analyzed in rice genome. The cultivar Nipponbare (Oryza sativa ssp. japonica) harbors 178,533 MITE-related sequences classified into 338 families. Pairwise nucleotide diversity phylogenetic tree analysis indicated that individual MITE families were resulted from one or multiple rounds...
Formins, an important family of force-bearing actin-polymerizing factors, function as homodimers that bind with the barbed end actin filaments through a ring-like structure assembled from dimerized FH2 domains. It has been hypothesized force applied to formin may facilitate transition ring inhibitory closed conformation permissive open conformation, speeding up polymerization. We confirm this hypothesis for mDia1 dependent polymerization by stretching single-actin filament in absence...
The mechanical stability of proteins has been extensively studied using AFM as a single-molecule force spectroscopy method. While this led to many important results, these studies have mainly limited fast unfolding at high-force regime due the rapid drift in most stretching experiments. Therefore, there is gap between knowledge obtained and properties lower which often more physiologically relevant. Recent demonstrated that can be addressed by single protein molecules magnetic tweezers,...
On-site detection demands are quickly increasing to control foodborne pathogenic bacteria along with the long food supply chains. Combining isothermal recombinase polymerase amplification (RPA) lateral flow strips (LFS) is a promising molecular approach for short reaction time, low condition, and simple "instrument-free" procedure. However, method comes non-negligible intrinsic risk of primer-dependent artifacts. In this study, an important bacterium Salmonella enterica serotype Typhimurium...
Group I Intron Sequence and Structure Database (GISSD) is a specialized comprehensive database for group introns, focusing on the integration of useful intron information from available databases providing de novo data that essential understanding these introns at systematic level. This presents 1789 complete records, including nucleotide sequence each annotated plus 15 nt upstream downstream exons, pseudoknots-containing secondary structures predicted by integrating comparative analyses...
Two single nucleotide polymorphisms (SNPs) in the human SLCO1B1 gene, c.388A>G (rs2306283) and c.521T>C (rs4149056), are independent determinants of efficacy side effects statin drugs. Multinational clinical guidelines...
Growing evidence indicates that abnormal liquid-liquid phase separation (LLPS) can disrupt biomolecular condensates, contributing to cancer development and progression. However, the influence of LLPS on prognosis head neck squamous cell carcinoma (HNSCC) patients its effects tumor immune microenvironment (TIME) are not yet fully understood. Therefore, we aimed categorize with HNSCC based LLPS-related genes explored their multidimensional heterogeneity. We integrated transcriptomic data 3,541...
The etiology of esophageal squamous cell cancer (ESCC) in high prevalence regions China remains unclear.Endoscopic biopsies were conducted among 7381 inhabitants aged from 25 to 65 Anyang, China.In this study, 2.57, 0.20 and 0.16% the participants had mild, moderate severe dysplasia, respectively; 0.19 0.08% showed carcinoma situ invasive ESCC. Using deep well (depth >100 meters) as water source (odds ratio=0.72, 95% confidence interval: 0.54-0.96) was negatively associated with ESCC its...
Cyclobutane pyrimidine dimers (CPDs) are the major products of DNA produced by direct absorption UV light, and result in C to T mutations linked human skin cancers. Most recently a new pathway CPDs melanocytes has been discovered that proposed arise from chemisensitized involving triplet sensitizer increases mutagenesis increasing percentage C-containing CPDs. To investigate how sensitization may differ irradiation, CPD formation was quantified 129-mer designed contain all 64 possible NYYN...
Frictional drag force on an object in Stokes flow follows a linear relationship with the velocity of translation and translational coefficient. This coefficient is related to size, shape, orientation object. For rod-like objects, analytical solutions coefficients have been proposed based three rough approximations rod geometry, namely bead model, ellipsoid cylinder model. These theories all agree that objects are functions length aspect ratio, but differ among one another correction factor...
Polyethylene glycol modification (PEGylation) is a widely used strategy to improve the physicochemical properties of various macromolecules, especially protein drugs. However, its application in enhancing performance enzymes for molecular biology remains underexplored. This study explored PEGylation Bst DNA polymerase, determining optimal reaction conditions. In comparison unmodified wild-type counterpart, modified polymerase exhibited significantly improved activity, thermal stability, and...
A set of three nonlinear partial-differential equations is derived for general finite deformations a thin membrane. The material that composes the membrane assumed to be hyperelastic. Its mechanical property represented by neo-Hookean strain-energy function. reduce special cases known in literature. fast convergent algorithm developed. numerical solutions finite-difference approximation differential are computed iteratively with trivial initial iterant. As an example, problem inflating...
The interaction between the single-stranded DNA and homologous duplex is essential for repair. Here, we report that parallel triplex structure can form spontaneously a mechanically extended ssDNA dsDNA in protein-free condition. has contour length close to of B-form remains stable after force released. binding energy estimated be comparable basepairing dsDNA. As similar conformation within recombinase-coated nucleoprotein filaments, propose may serve as an intermediate during...