A5087541066- HIV-related health complications and treatments
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Neurological and metabolic disorders
- Disaster Response and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Bacillus and Francisella bacterial research
- Risk Perception and Management
- Stroke Rehabilitation and Recovery
- Terrorism, Counterterrorism, and Political Violence
- Nanocluster Synthesis and Applications
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Gastrointestinal motility and disorders
- HIV/AIDS drug development and treatment
- Disaster Management and Resilience
- Bipolar Disorder and Treatment
- Health, psychology, and well-being
- Cytomegalovirus and herpesvirus research
- Alzheimer's disease research and treatments
- Psychosomatic Disorders and Their Treatments
Washington University in St. Louis
2004-2023
Neurology, Inc
2016
Objectives: Studies of HIV-associated brain atrophy often focus on a priori regions interest, which can introduce bias. A data-driven, minimally biased approach was used to analyze changes in volumetrics associated with HIV and their relationship aging, viral factors, combination antiretroviral therapy (cART), gender, smoking. Design: cross-sectional study 51 HIV-uninfected (HIV−) 146 HIV-infected (HIV+) participants. Methods: Structural MRI participants analyzed using principal component...
Inflammation occurs after HIV infection and persists, despite highly active antiretroviral therapy (HAART). Diffusion tensor imaging (DTI) measures HIV-associated white matter changes, but can be confounded by inflammation. Currently, the influence of inflammation on integrity in well-controlled HIV+ patients remains unknown. We used diffusion basis spectral (DBSI)-derived cellularity to isolate restricted water associated with separated from anisotropic axonal integrity. Ninety-two...
Abstract Background While antiretroviral therapy (ART) has improved outcomes for people with HIV (PWH), brain dysfunction is still evident. Immune activation and inflammation remain elevated in PWH receiving ART, thereby contributing to morbidity mortality. Previous studies demonstrated reduced functional structural changes PWH; however, underlying mechanisms elusive. Methods Our cohort consisted of ART adherence viral suppression ( < 50 copies/mL; N = 173). Measurements included...
Little systematic information is available on mental health issues related to bioterrorism. Five focus groups were conducted with Capitol Hill office staff (n = 28 total participants) learn about their experience of the anthrax incident October 15, 2001. More than 2,000 verbal passages coded into categories and themes by using qualitative analysis software. Issues emerging from discussions included difficulties utilizing customary social supports, concerns over potential long-term dangers...
Systematic studies of mental health effects bioterrorism on exposed populations have not been carried out. Exploratory focus groups were conducted with an population to provide qualitative data and inform empirical research. Five 28 political worker volunteers 3 months after the October 15, 2001, anthrax attack Capitol Hill. More than 2000 transcribed group passages categorized using software. The category most items was authorities’ response (23% passages), much this discussion pertained...
Introduction Progression to symptomatic Alzheimer disease (AD) occurs slowly over a series of preclinical stages. Declining functional mobility may be an early indicator loss brain network integration and lead increased risk experiencing falls. It is unknown whether measures falls are markers AD. The purpose this study examine (1) the relationship between with AD biomarkers determine when occur within temporal progression disease, (2) attentional compared perceptual/motor systems that...
Abstract Background Persons with HIV (PWH) are at increased risk of frailty, a clinically recognizable state vulnerability resulting from aging-associated decline in multiple physiologic systems. Frailty is often defined by the Fried criteria, which includes subjective and objective standards concerning health resiliency. However, these frailty metrics do not incorporate cognitive performance or neuroimaging measures. Methods We compared structural (diffusion tensor imaging [DTI]) functional...
The purpose of this exploratory study was to investigate the 9/11-related experiences, observations, and perceptions airline flight staff highly connected terrorist attacks effects on their work. A focus group seven conducted in January 2004. Spoken passages (N = 115) were categorized into themes, with excellent interrater reliability. Item count frequencies tabulated for each theme. Five themes emerged: disaster experience, emotional response, perceived danger, interpersonal workplace...
Background With the advent of antiretrovirals, people living with HIV are near-normal lifespans. However, at greater risk experiencing cognitive impairment and reduced brain integrity despite well-controlled viremia. A robust literature supports exercise interventions as a method improving cognition structural in older individuals without HIV. The effects on cardiometabolic, neurocognitive, neural structures middle-aged to less well known, few prospective studies examining these measures....
Integrase inhibitors (INSTIs) have been associated with poorer cognition in people HIV (PWH). We examined the impact of switching to INSTIs on neuropsychological (NP) outcomes PWH 40 years age and older.
<sec> <title>BACKGROUND</title> With the advent of antiretrovirals, people living with HIV are near-normal lifespans. However, at greater risk experiencing cognitive impairment and reduced brain integrity despite well-controlled viremia. A robust literature supports exercise interventions as a method improving cognition structural in older individuals without HIV. The effects on cardiometabolic, neurocognitive, neural structures middle-aged to less well known, few prospective studies...