A5015393194- HIV-related health complications and treatments
- HIV Research and Treatment
- Neurological and metabolic disorders
- Advanced Neuroimaging Techniques and Applications
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Genomics and Rare Diseases
- Ethics and Legal Issues in Pediatric Healthcare
- Ophthalmology and Visual Health Research
- Aquatic and Environmental Studies
- Suicide and Self-Harm Studies
- Bipolar Disorder and Treatment
- Complex Systems and Decision Making
- Medical Education and Admissions
- Intramuscular injections and effects
- COVID-19 Impact on Reproduction
- Child Abuse and Related Trauma
- Obstructive Sleep Apnea Research
- HIV/AIDS drug development and treatment
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Stroke Rehabilitation and Recovery
- Amyotrophic Lateral Sclerosis Research
- Multisensory perception and integration
Washington University in St. Louis
1988-2023
Vanderbilt University
2023
Chester County Hospital
2022
Anderson University - South Carolina
2020
Centre for Nursing Innovation
2020
Michigan Technological University
2018
Neurology, Inc
2016
Monroe Carell Jr. Children's Hospital
2014
Objectives: Studies of HIV-associated brain atrophy often focus on a priori regions interest, which can introduce bias. A data-driven, minimally biased approach was used to analyze changes in volumetrics associated with HIV and their relationship aging, viral factors, combination antiretroviral therapy (cART), gender, smoking. Design: cross-sectional study 51 HIV-uninfected (HIV−) 146 HIV-infected (HIV+) participants. Methods: Structural MRI participants analyzed using principal component...
People living with HIV (PLWH) may be at higher risk for adverse outcomes indirectly associated the severe acute respiratory syndrome coronavirus (SARS-CoV-2). When comparing responses to questionnaires administered when social distancing and quarantine guidelines were first implemented, we found that PLWH more likely have restricted access medical care, increased financial stress, symptoms of anxiety depression, substance use compared demographically-similar people without HIV.
Inflammation occurs after HIV infection and persists, despite highly active antiretroviral therapy (HAART). Diffusion tensor imaging (DTI) measures HIV-associated white matter changes, but can be confounded by inflammation. Currently, the influence of inflammation on integrity in well-controlled HIV+ patients remains unknown. We used diffusion basis spectral (DBSI)-derived cellularity to isolate restricted water associated with separated from anisotropic axonal integrity. Ninety-two...
Abstract Background While antiretroviral therapy (ART) has improved outcomes for people with HIV (PWH), brain dysfunction is still evident. Immune activation and inflammation remain elevated in PWH receiving ART, thereby contributing to morbidity mortality. Previous studies demonstrated reduced functional structural changes PWH; however, underlying mechanisms elusive. Methods Our cohort consisted of ART adherence viral suppression ( < 50 copies/mL; N = 173). Measurements included...
Purpose The purpose of this project was for advanced practice nursing students to gain experience taking a history from parent or caregiver and communicating the treatment plan an infant in which child abuse is suspected. Project Fifty-three participated 1:1 simulated encounter with standardized patient acting as mother leg injury that reportedly resulted fall couch. Students received feedback via assessment tool debriefed faculty immediately after simulation. Outcome All demonstrated...
As people with human immunodeficiency virus (HIV) (PWH) age, it remains unclear whether they are at higher risk for age-related neurodegenerative disorders-for example, Alzheimer disease (AD)-and, if so, how to differentiate HIV-associated neurocognitive impairment from AD. We examined a clinically available blood biomarker test AD (plasma amyloid-β [Aβ] 42/Aβ40 ratio) in PWH who were cognitively normal (PWH_CN) or impaired (PWH_CI) and without HIV (PWoH) (PWoH_CN) had symptomatic (PWoH_AD).
Abstract Background Persons with HIV (PWH) are at increased risk of frailty, a clinically recognizable state vulnerability resulting from aging-associated decline in multiple physiologic systems. Frailty is often defined by the Fried criteria, which includes subjective and objective standards concerning health resiliency. However, these frailty metrics do not incorporate cognitive performance or neuroimaging measures. Methods We compared structural (diffusion tensor imaging [DTI]) functional...
Background With the advent of antiretrovirals, people living with HIV are near-normal lifespans. However, at greater risk experiencing cognitive impairment and reduced brain integrity despite well-controlled viremia. A robust literature supports exercise interventions as a method improving cognition structural in older individuals without HIV. The effects on cardiometabolic, neurocognitive, neural structures middle-aged to less well known, few prospective studies examining these measures....
To explore the relationship between various levels of academic achievement and spectrum initial specialty placements for graduates.The authors studied all 1984-1994 graduates University Kentucky College Medicine. Statistical analyses were used to determine nature strength relationships selection students' indicators changes in that over time.Students tended aggregate across time into discernible achievement. The highly variable.Although students with higher had broader choices available...
Despite improved survival rates, neurocognitive impairment persists in persons living with HIV (PLWH). An active lifestyle is linked to cognition among PLWH, yet the neural substrates remain unclear. Diffusion tensor imaging and diffusion basis spectrum measure HIV-related changes brain white matter integrity. We used these measures of structural integrity assess changes, physical fitness, a cross-sectional study PLWH.
Auditory displays are a useful platform to convey information users for variety of reasons. The present study sought examine the use different types sounds that can be used in auditory displays—music, earcons, spearcons, and lyricons—to determine which have highest learnability when presented sequences. Participants were self-trained on sound meanings then asked recall after listening sequences varying lengths. relatedness their attributed meanings, or intuitiveness sounds, was also...
Background and purpose AV ‐1451 ( 18 F‐ ‐1451, flortaucipir) positron emission tomography was performed in C9orf72 expansion carriers to assess tau accumulation disease manifestation. Methods Nine clinically characterized age‐ gender‐ matched cognitively normal individuals were psychometrically evaluated underwent imaging. The regional standard uptake value ratios from multiple brain regions analyzed. Spearman correlation relate the ratio clinical, psychometric cerebrospinal fluid measures....
Background Substantial body composition alterations have been reported after starting combined antiretroviral therapy (cART). We characterized a cohort of chronically infected and virologically suppressed (VL < 50 copies/ml) men (≥50 years old) living with HIV (MLWH) who were switched to integrase inhibitors (INSTI), compared their parameters proinflammatory/endocrine profiles age-matched MLWH on inhibitor free (non-INSTI) regimens, taking into account neighborhood-level measures...
C9orf72 repeat-related disease is the most common cause of hereditary amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Similar to Alzheimer's (AD), some expansion carriers who are cognitively impaired have been shown increases in tau neurofibrillary tangles at autopsy. Recently developed positron emission tomography (PET) imaging could potentially be an vivo method assess accumulation C9orf72-related disease. We evaluated AV-1451 PET as a diagnostic prognostic biomarker...
The field of cancer genetic testing has made great advances in correctly identifying patients at risk for hereditary syndromes. These tests, used during a consultation, promote earlier detection and potentially increase survival. Despite these advancements, large number persons BRCA1/2 mutations remain untested due to shortage counselors lack clinician knowledge on how properly screen, identify, refer counseling. We suggest team-based practices that physician associates/assistants (PAs) NPs...
Background/Purpose: Quality indicators, such as infection and cardiovascular disease (CVD) preventive care, for patients with systemic lupus erythematosus (SLE) have recently been published can be utilized assessing quality of care. Implementation tools clinical decision support (CDS) within the electronic health record (EHR) in care improvement efforts. The purpose this study is to test chronic model relationship between CDS rates compliance CVD indicators pediatric SLE at an outpatient...
<sec> <title>BACKGROUND</title> With the advent of antiretrovirals, people living with HIV are near-normal lifespans. However, at greater risk experiencing cognitive impairment and reduced brain integrity despite well-controlled viremia. A robust literature supports exercise interventions as a method improving cognition structural in older individuals without HIV. The effects on cardiometabolic, neurocognitive, neural structures middle-aged to less well known, few prospective studies...