A5101539226- Pharmacological Effects of Natural Compounds
- FOXO transcription factor regulation
- Seaweed-derived Bioactive Compounds
- Biochemical effects in animals
- Gut microbiota and health
- Herbal Medicine Research Studies
- Autophagy in Disease and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Echinoderm biology and ecology
- Medicinal Plants and Bioactive Compounds
- Heat shock proteins research
- Polysaccharides Composition and Applications
- Mycotoxins in Agriculture and Food
- Oral health in cancer treatment
- Neuropeptides and Animal Physiology
- Enzyme Structure and Function
- 3D Printing in Biomedical Research
- Trace Elements in Health
- Protein Tyrosine Phosphatases
- Biochemical and Molecular Research
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Cystic Fibrosis Research Advances
Shanxi Medical University
2023
China Agricultural University
2017-2021
Ocean University of China
2014-2016
The University of Texas Health Science Center at San Antonio
1996
Secretory immunoglobulin A (SIgA) is a non-inflammatory antibody that shields internal body surfaces, such as in the intestine to neutralize pathogens lumen of intestine. As chemotherapy seriously damages mucosal immune system, we herein demonstrated polysaccharide from squid ink Ommastrephes bartrami (OBP) activated intestinal SIgA secretion prevent chemotherapeutic injury. Using mouse model induced injury by intraperitoneal injection 50 mg kg−1 cyclophosphamide, our results showed an...
Background and Purpose Acetaminophen‐induced acute liver injury (AILI) is the most frequent cause of failure in developed countries. Given significant limitations associated with N‐acetyl cysteine, only antidote used to treat AILI, development novel therapeutic approaches that can offer a wide range time‐windows clearly needed. Glycycoumarin (GCM), natural coumarin purified from liquorice, has been previously demonstrated possess potent hepatoprotective effects. In present study, we aimed...
Gastrointestinal mucositis and infection by chemotherapy treatment are associated with alteration of intestinal microflora bacterial translocation due to the potential damage induced anti-cancer drugs on barrier microbiota homeostasis. This study aimed investigate protective effect dietary polysaccharides dysfunction. In current contribution, a mouse model intraperitoneally injected 50 mg kg−1 cyclophosphamide (Cy) for 2 days, we revealed that from ink Ommastrephes bartrami (OBP) altered...
MET overactivation is one of the crucial reasons for tyrosine kinase inhibitor (TKI) resistance, but mechanisms are not wholly clear. Here, COX2, TOPK, and expression were examined in EGFR-activating mutated NSCLC by immunohistochemical (IHC) analysis. The relationship between was explored vitro ex vivo. In addition, inhibition HCC827GR cell growth combining COX2 (celecoxib), TOPK (pantoprazole), gefitinib verified vivo We found that highly expressed progression-free survival (PFS)...
Previous studies have shown that selenite, a representative of inorganic form selenium, exerts its anticancer effect by inducing apoptosis in androgen-dependent LNCaP prostate cancer cells, but few determined the nature cell death induced selenite metastatic androgen-refractory PC-3 cells. Our study showed necrosis-like rather than apoptosis, pyroptosis, or autophagic was caused Mechanistically, this type ATP depletion (26.28 ± 3.39 nmol/mg control versus 9.12 2.44 10 μM treatment) resulted...
Patulin (PAT) is the most common food-borne mycotoxin found in fruits and fruit-derived products, while chlorpyrifos (CPF) a widely used pesticide on fruit other crops. On basis of residue data, certain types can be contaminated simultaneously by patulin chlorpyrifos. However, there are no available data about combined toxicity. Since liver possible toxic target both chlorpyrifos, we tested whether combination exposure cause enhanced hepatotoxicity using cell culture animal models. Results...
Abstract Acetaminophen (APAP)‐induced acute liver injury (AILI) is the most frequent cause of failure in developed countries. Trimethylamine N‐oxide (TMAO) a metabolite derived from gut microbiota and relatively high circulation elderly, individuals with diabetes, heart disease. Herein, we showed that TMAO exacerbates APAP hepatotoxicity. It possible delayed repair regeneration resulted reduced macrophage accumulation was responsible for this combined Moreover, matrix metalloproteinase 12...
sigma E and K are sporulation-specific factors of Bacillus subtilis that synthesized as inactive proproteins. Pro-sigma pro-sigma activated by the removal 27 20 amino acids, respectively, from their termini. To explore properties precursor-specific sequences, we exchanged coding elements for these domains in structural genes determined resulting chimeric proteins B. subtilis. The E-sigma chimera accumulated was cleaved into active K, while K-sigma fusion protein failed to accumulate is...
Abstract Increasing bodies of evidence support the involvement tumor‐intrinsic action in PD‐L1‐mediated cancer progression. However, mechanisms underlying function PD‐L1 are less well understood. In present study, we found a positive correlation between expression and MET phosphorylation lung melanoma cell lines. inhibition led to decrease phosphorylation, while induction by IFN‐γ resulted PD‐L1‐dependent increase both vitro vivo. The results indicated that can be positively regulated PD‐L1....
Background: Sea cucumber (class Holothuroidea, phylum Echinodermata) is a marine food rich in valuable nutrients and confirmed to have antifatigue effects. This study aimed compare the activity of five sea species from China Thailand. Materials Methods: A mouse model effective intense exercise was used. Blood levels lactic acid (LA), creatine kinase (CK), liver muscle glycogen content, malondialdehyde (MDA) content blood superoxide dismutase (SOD) were investigated. Results: Holothuria...
Maintaining the integrity and stability of gut tract is essential for health body. Autophagy a promising target balancing homeostasis, numerous studies have focused on regulating autophagy to improve health. In this study, we found that glycyrol (GC), representative coumarin compound isolated from Glycyrrhiza uralensis Fisch (used medicine food), can attenuate colon injury by activating autophagy. Specifically, demonstrated GC act ubiquitin-specific protease 8 (USP8), inhibit interaction...
Gefitinib has been clinically demonstrated to be effective in the first-line setting for patients with advanced EGFR-mutated non-small cell lung cancer (NSCLC). However, acquired therapeutic resistance gefitinib almost unavoidably develops, posing a major hurdle its clinical utilization. Our previous study showed that glycyrol (GC), representative of coumarin compounds isolated from medicinal plant licorice, was against A549 cells both culture and murine xenograft model. In this follow-up...
Sea cucumber is a food with nutritional benefits distributing mainly in Asia, and Apostichopus japonicus (A. japonicus) kind of sea whose quality better than any others. However, different processing methods make various effect on its quality. In this study, we evaluated the protection A. mice ulcerative colitis induced by trinitrobenzene sulfonic acid (TNBS), especially intestinal microflora. The expression IFN-γ/IL-4 IL-1β gut, microbiota were discussed. results revealed that three could...
Background: MET overactivation is one of the crucial reasons for tyrosine kinase inhibitors (TKIs) resistance. Cyclooxygenase2 (COX2), a rate-limiting enzyme that converts arachidonic acid to prostaglandins (PGs), and T lymphokine-activated killer cell-originated protein (TOPK) are involved in many neoplastic tissues. Coincidently, we found COX2 TOPK were highly expressed gefitinib-resistant HCC827 (HCC827GR) cells with overactivation. But relationship between COX2, gefitinib-resistance...