A5085394289- Innovations in Medical Education
- Kruppel-like factors research
- Chromatin Remodeling and Cancer
- CRISPR and Genetic Engineering
- Clinical Reasoning and Diagnostic Skills
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Renal and related cancers
- Transplantation: Methods and Outcomes
- Infectious Disease Case Reports and Treatments
- Pluripotent Stem Cells Research
- Circular RNAs in diseases
- Mechanical Circulatory Support Devices
- Electrospun Nanofibers in Biomedical Applications
- Genomics and Chromatin Dynamics
- Health Sciences Research and Education
- Cardiac Fibrosis and Remodeling
- Acute Kidney Injury Research
- Medical Education and Admissions
- Health and Medical Research Impacts
- Healthcare professionals’ stress and burnout
- RNA Research and Splicing
- Fungal Infections and Studies
- Congenital heart defects research
- Actinomycetales infections and treatment
Stanford University
2020-2023
Palo Alto University
2022-2023
Eastern Virginia Medical School
2020-2022
California Institute for Regenerative Medicine
2017
University of California, Berkeley
2016
Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote beneficial response. We show under LSS, KLF4 interacts with SWI/SNF nucleosome remodeling complex increase accessibility at enhancer sites of homeostatic genes. By combining molecular and computational approaches discover enhancers loop promoters KLF4- LSS-responsive genes stabilize cells...
Transcription factor (TF)-directed enhanceosome assembly constitutes a fundamental regulatory mechanism driving spatiotemporal gene expression programs during animal development. Despite decades of study, we know little about the dynamics or order events animating TF at cis-regulatory elements in living cells and long-range molecular "dialog" between enhancers promoters. Here, combining genetic, genomic, imaging approaches, characterize complex enhancer cluster governing Krüppel-like 4...
Abstract Physiologic laminar shear stress (LSS) induces an endothelial gene expression profile that is vasculo-protective. In this report, we delineate how LSS mediates changes in the epigenetic landscape to promote beneficial response. We show under LSS, KLF4 interacts with SWI/SNF nucleosome remodeling complex increase accessibility at enhancer sites of homeostatic genes. By combining molecular and computational approaches discovered enhancers loop promoters known novel KLF4-...
OPEN ACCESSNovember 24, 2020Peer-Developed Modules on Basic Biostatistics and Evidence-Based Medicine Principles for Undergraduate Medical Education Daniel H. Mai, Jonathan S. Taylor-Fishwick, William Sherred-Smith, MS, Anthony Pang, Justin Yaworsky, Sean Whitty, Alex Lafever, Cody Mcilvain, Mark Schmitt, MBS, Michelle Rogers-Johnson, PhD, April Pace, MLS, Anca D. Dobrian, PhD Mai Student, School of Medicine, Eastern Virginia E-mail Address: [email protected] , Taylor-Fishwick MS Yaworsky...
Although clinical leadership in physicians is associated with improved healthcare, training rarely integrated into residency training. Our objective was to perform a comprehensive needs assessment of our pediatric residents' existing experiences and knowledge identify gaps within program.First, we held focus groups senior residents understand their needs. Notes were transcribed independently coded by 2 researchers, thematic saturation achieved. Next, focused each session on 1 content area...
Clinical leadership is an essential skill for physicians, empowering them to lead and coordinate teams, communicate clearly under various conditions, model positive behaviors, display emotional intelligence, ultimately improve patient care outcomes. However, there are currently no standardized residency curricula or competency-based assessments clinical leadership, as residents often assimilate skills through trial-and-error observation of their faculty. By utilizing a comprehensive needs...
Nocardia infections are rare opportunistic in SOT recipients, with few reported pediatric cases. Pediatric patients single ventricle congenital heart defects requiring HT may be more susceptible to due a decreased T-cell repertoire from early thymectomy and potential immunodeficiencies related their disease. Other risk factors recipients include the use of immunosuppressive medications development persistent lymphopenia, delayed count recovery and/or lymphocyte dysfunction.We report case...
Event Abstract Back to Hydrogel degradation modulates human iPSC-derived cardiomyocyte fates in 3D Soah Lee1, Vahid Serpooshan2, Daniel Hu3, Xinming Tong4, Sean Wu2 and Fan Yang3, 4 1 Stanford University, Materials Science Engineering, United States 2 Cardiovascular Institute, 3 Bioengineering, Orthopedic Surgery, Introduction: Myocardial infarction (MI) is an irreversible necrosis of myocardial tissue due prolonged ischemia, the leading cause death US. Human induced pluripotent stem cells...
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Abstract Background The development of acute kidney injury (AKI) has been associated with worse outcomes in children after heart transplantation. Our study compares the application a cumulative six‐point Kidney Diseases Improving Global Outcomes (KDIGO) AKI scoring system, utilizing both creatinine and urine output criteria that we term as AKI‐6 criteria, to traditional staging predictor for clinical renal pediatric transplant recipients. Methods We conducted retrospective single‐center...