A5021819422- Social and Educational Sciences
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Pharmacogenetics and Drug Metabolism
- Vector-borne infectious diseases
- Effects and risks of endocrine disrupting chemicals
- Neuropeptides and Animal Physiology
- Insect and Pesticide Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Maternal and Perinatal Health Interventions
- Research in Social Sciences
- Carcinogens and Genotoxicity Assessment
- Biochemical and Molecular Research
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Peatlands and Wetlands Ecology
- Corneal surgery and disorders
- Pneumonia and Respiratory Infections
- Viral Infections and Vectors
- Blood disorders and treatments
- Glutathione Transferases and Polymorphisms
- HIV/AIDS drug development and treatment
- Soil and Water Nutrient Dynamics
- Cancer, Stress, Anesthesia, and Immune Response
Uppsala University
2015-2025
Uppsala University Hospital
2016-2022
Karolinska Institutet
2015-2022
University of Gothenburg
2022
Sahlgrenska University Hospital
2022
Karolinska University Hospital
2022
Centre of Registers Vastra Gotaland
2022
University of Oslo
2017
Swedish University of Agricultural Sciences
2004-2016
Woods Hole Oceanographic Institution
2007-2012
Increasing use of zebrafish in drug discovery and mechanistic toxicology demands knowledge cytochrome P450 (CYP) gene regulation function. CYP enzymes catalyze oxidative transformation leading to activation or inactivation many endogenous exogenous chemicals, with consequences for normal physiology disease processes. Many CYPs potentially have roles developmental specification, chemicals that cause abnormalities are substrates CYPs. Here we identify annotate the full suite genes zebrafish,...
Halogenated agonists for the aryl hydrocarbon receptor (AHR), such as 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), cause developmental toxicity in fish. AHR dependence of these effects is known TCDD but only presumed PCB126, AHR-regulated genes involved are part. We defined role regulation four cytochrome P450 1 (CYP1) effect PCB126 on cell cycle (i.e., PCNA cyclin E) zebra fish (Danio rerio) embryos. Basal PCB126-induced expression CYP1A, CYP1B1,...
ABSTRACT Convergent evidence associates endocrine disrupting chemicals (EDCs) with major, increasingly-prevalent human disorders. Regulation requires elucidation of EDC-triggered molecular events causally linked to adverse health outcomes, but two factors limit their identification. First, experiments frequently use individual chemicals, whereas real life entails simultaneous exposure multiple EDCs. Second, population-based and experimental studies are seldom integrated. This drawback was...
The triazine class of herbicides includes the compounds ametryn, atrazine, and simazine, which are used to control weeds in plantations crops such as maize, sorghum, sugar cane. Despite their acceptance agriculture, these can be dangerous environment, depending on toxicity, degree contamination, duration exposure. Controlled release systems increasingly mitigate problems toxicity minimize environmental impacts, also increase herbicide efficiency. objective this work was prepare...
Many industrial sites are polluted by complex mixtures of polycyclic aromatic compounds (PACs). Besides hydrocarbons (PAHs), these often contain significant amounts more polar PACs including oxygenated PAHs (oxy-PAHs). The effects oxy-PAHs are, however, poorly known. Here we used zebrafish embryos to examine toxicities and transcriptional changes induced PAC containing soil extracts from three different sites: a gasworks (GAS), former wood preservation site (WOOD), coke oven (COKE), PAH...
Biochemical and immunochemical studies of the outer membrane proteins Borrelia burgdorferi have shown that OspA OspB from strains different geographic origins may differ considerably in their reactivities with monoclonal antibodies apparent molecular weights. To further characterize this variation Osp between strains, osp operons deduced translation products two one Sweden (ACAI) eastern Russia (Ip90), were studied. Polyacrylamide gel electrophoresis Western blot (immunoblot) analyses...
Altered intestinal barrier function has been implicated in the pathophysiology of ulcerative colitis (UC) genetic, functional, and epidemiological studies. Mast cells corticotropin-releasing factor (CRF) regulate mucosal human colon. Because eosinophils are often increased colon tissues patients with UC, we assessed interactions among mast cells, CRF, these patients.Transmucosal fluxes protein antigens (horseradish peroxidase) paracellular markers ((51)Cr-EDTA, fluorescein...
BACKGROUND: Preeclampsia is associated with an increased lifetime risk of myocardial infarction. This study explored whether there a difference in the clinical features and severity infarction women previous preeclampsia compared no history preeclampsia. METHODS: register-based cohort combined data from Swedish Medical Birth Register quality register Web-System for Enhancement Development Evidence-Based Care Heart Disease Evaluated According to Recommended Therapies. Women first singleton...
6-Formylindolo[3,2-b]carbazole (FICZ) is a potent aryl hydrocarbon receptor (AHR) agonist that efficiently metabolized by AHR-regulated cytochrome P4501 enzymes. FICZ proposed physiological AHR ligand induces its own degradation as part of regulatory negative feedback loop. In vitro studies in cells show CYP1 inhibition the presence results enhanced activation, suggesting accumulates cell when metabolism blocked. We used zebrafish (Danio rerio) embryos to investigate vivo effects CYP1A...
Abstract Background Postpartum depression (PPD) is a common disorder after childbirth. The strongest known predictors are history of and/or PPD. However, for significant proportion women, PPD constitutes their first depressive episode. This study aimed to gain further insight into the risk factors in time mothers without previous psychiatric contact. Methods Women delivering Uppsala University Hospital, Sweden, from May 2006 June 2007, were asked participate and filled out questionnaires...
Borrelia burgdorferi, an agent of Lyme disease, is killed by some monoclonal antibodies in the absence complement or phagocytes. In present study, bactericidal action against B. burgdorferi and hermsii, a cause relapsing fever, was further characterized. H6831, antibody recognizing OspB proteins strains, H4825, specific for one serotype were purified, Fab fragments prepared. time-kill studies, more than 99.9% strain B31 cells after 30 min exposure to H6831 fragments. The MBC 10...
The seed banks in the soils of seven mature beech forests southern Sweden were examined using seedling‐emergence method. Seedling emergence field was also studied. In studied forests, covering a wide range vegetation and soil types, between 1020 4500 germinating seeds m −2 found bank. Seed abundance showed no apparent relationship with type or at sites, but highest number species bank on mull sites. diversity germinative increased strongly increasing fertility. Only minor part (10–35%)...
The body has not only a neuronal but also nonneuronal cholinergic system. Both systems are likely to be very important, particularly in inflammatory conditions. patterns and importance of the system patients with ulcerative colitis (UC) largely unknown.The colons UC non-UC were examined for expression choline acetyltransferase (ChAT), vesicular acetylcholine transporter (VAChT), muscarinic receptor M(2) subtype.ChAT VAChT immunoreactions mRNA reactions ChAT detected epithelial endocrine...
A constructed lactate dehydrogenase (LDH)-negative mutant of Enterococcus faecalis V583 grows at the same rate as wild type but ferments glucose to ethanol, formate, and acetoin. Microarray analysis showed that LDH deficiency had profound transcriptional effects: 43 genes in were found be upregulated, 45 downregulated. Most upregulated encode enzymes energy metabolism or transport. By two-dimensional (2D) gel analysis, differentially expressed proteins identified. comparison transcriptomic...