A5027919886- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Inhalation and Respiratory Drug Delivery
- Cancer, Hypoxia, and Metabolism
- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Chemical Synthesis and Analysis
- Autophagy in Disease and Therapy
- Sulfur Compounds in Biology
- Alcohol Consumption and Health Effects
- Skin Protection and Aging
- Peroxisome Proliferator-Activated Receptors
- Nanoparticle-Based Drug Delivery
- Dermatologic Treatments and Research
- Drug Solubulity and Delivery Systems
- Mesenchymal stem cell research
- Advanced biosensing and bioanalysis techniques
- Microencapsulation and Drying Processes
- Computational Drug Discovery Methods
- Nanomaterials for catalytic reactions
- Endoplasmic Reticulum Stress and Disease
- Pharmaceutical studies and practices
- Laser Applications in Dentistry and Medicine
- Heme Oxygenase-1 and Carbon Monoxide
- Eicosanoids and Hypertension Pharmacology
Anglia Ruskin University
2016-2025
University of Wolverhampton
2014
Al-Baath University
2012-2013
University of Manchester
2005-2007
University of Central Lancashire
2006-2007
The anticancer activity of disulfiram (DS) is copper(ii) (Cu)-dependent. This study investigated the mechanisms DS/Cu using in vitro cytotoxicity and metabolic kinetic analysis. Our indicates that targets cancer cells by combination two types actions: (1) instant killing executed reaction generated reactive oxygen species; (2) delayed introduced end product, DDC-Cu. Nanoencapsulation DS might shed light on repositioning into treatment.
Disulfiram (DS), an anti-alcoholism medicine, shows strong anti-cancer activity in the laboratory, but application clinics for therapy has been limited by its prompt metabolism. Conventional liposomes have shown ability to protect DS. Therefore, aim of this study is develop PEGylated DS enhanced bio-stability and prolonged circulation. were prepared using ethanol-based proliposome methods. Various ratios phospholipids, namely: hydrogenated soya phosphatidylcholine (HSPC) or dipalmitoyl...
The aim of this study is to investigate using nanoemulsion formulations as drug-delivery vehicles paclitaxel (PX), a poor water-soluble anticancer drug. Two commercially available fat (Clinoleic 20% and Intralipid 20%) were loaded with PX characterised based on their size, zeta potential, pH loading efficiency. effect formulation the cytotoxicity was also evaluated MTT assay. droplet size Clinoleic emulsion increased from 254.1 nm 264.7 when (6 mg/ml) into formulation, compared drug-free...
Disulfiram (DS) has been shown to have potent anti-cancer activity; however, it is also characterised by its low water solubility and rapid metabolism in vivo. Biodegradable polylactic-co-glycolic acid (PLGA) polymers frequently employed the manufacturing of PLGA nano-carrier drug delivery systems. Thus, develop DS-loaded nanoparticles (NPs) capable overcoming DS’s limitations, two methodologies were used formulate NPs: direct nanoprecipitation (DNP) single emulsion/solvent evaporation (SE),...
Background: Steric stabilization of liposomes using PEGylation has been used widely in pharmaceutical research to overcome the limitations conventional and extend circulation time. tended improve physicochemical stability reverse chemoresistance multidrug-resistant (MDR) breast cancer cell lines. In this study, PEGylated formulations disulfiram (DS) paclitaxel (PAC) were developed ethanol-based proliposome technology. Methods: liposomal approach combined with high-pressure homogenization...
Abstract Glioblastoma stem cell (GSC) is the major cause of glioblastoma multiforme (GBM) chemotherapy failure. Hypoxia one determinants GSC. NF-κB plays a pivotal link between hypoxia and cancer cells (CSCs). Disulfiram, an antialcoholism drug, has very strong NF-κB–inhibiting anti-CSC activity. In this study, in vitro anti-GSC activity disulfiram vivo anti-GBM efficacy poly lactic–co-glycolic acid nanoparticle-encapsulated (DS-PLGA) were examined. We attempt to elucidate molecular network...
Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) Tween 80 (T80) lipid composition. Proniosomes hydrated probe-sonicated to generate nano-vesicles. The proniosome powders characterized in terms morphology scanning electron microscopy, drug crystallinity differential calorimetry (DSC) X-ray diffraction (XRD). niosomes generated from compared conventional niosomes, size, zeta potential, entrapment, storage...
Diethyldithiocarbamate Copper II (DDC-Cu) has shown potent anticancer activity against a wide range of cancer cells, but further investigations are hindered by its practical insolubility in water. In this study, inclusion complexes DDC-Cu with hydroxypropyl beta-cyclodextrin (HP) or sulfobutyl ether (SBE) were prepared and investigated as an approach to enhance the apparent solubility DDC-Cu. Formulations simple mixing both cyclodextrin (CDs) at room temperature. Phase assessments resulting...
The aim of this study is to evaluate the potential use first-generation (G1) polyamidoamine (PAMAM) dendrimers as drug carriers enhance permeability, hence oral absorption, drugs that are substrates for P-glycoprotein (P-gp) efflux transporters. G1 PAMAM dendrimer-based prodrugs water-insoluble P-gp substrate terfenadine (Ter) were synthesized using succinic acid (suc) or succinyl-diethylene glycol (suc-deg) a linker/spacer (to yield G1-suc-Ter and G1-suc-deg-Ter, respectively). In addition,...