A5057729977- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Nutritional Studies and Diet
- Regulation of Appetite and Obesity
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
- Obesity, Physical Activity, Diet
- Stress Responses and Cortisol
- Nitric Oxide and Endothelin Effects
- Nutrition and Health in Aging
- HIV-related health complications and treatments
- Growth Hormone and Insulin-like Growth Factors
- Health and Well-being Studies
- Adipose Tissue and Metabolism
- Global Public Health Policies and Epidemiology
- Cardiovascular and exercise physiology
- Hormonal Regulation and Hypertension
- Hormonal and reproductive studies
- Pituitary Gland Disorders and Treatments
- Cardiac Health and Mental Health
North-West University
2012-2021
South African Medical Research Council
2017-2020
Huisman (Netherlands)
2013-2014
Northwest University
2010
Nutrition Sciences (Belgium)
2006
Wageningen University & Research
2000
Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals with optimal blood pressure (BP) (≤120/80 mm Hg), their 5-year prediction for the development hypertension. Methods The Prospective Urban Rural Epidemiology study North West Province, South Africa, started 2005 included volunteers (n = 1994; aged > 30 years) from a...
Background Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there a limited understanding population individual-specific cardiovascular pathophysiology – necessary for effective prevention treatment strategies Africa. As lack longitudinal studies tracking early pathophysiological development black populations, African-PREDICT study was...
Abstract Aims To compare the prevalence of electrocardiogram (ECG)-documented atrial fibrillation (or flutter) (AF) across eight regions world, and to examine antithrombotic use clinical outcomes. Methods results Baseline ECGs were collected in 153 152 middle-aged participants (ages 35–70 years) document AF two community-based studies, spanning 20 countries. Medication outcome data (mean follow-up 7.4 available one cohort. Cross-sectional analyses performed medication use, associations...
In Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We the profiles of different age groups and focused on muscular arteries two central segments in African Caucasian people from South Africa. (N = 374) 376) participants (20–70 years), we measured carotid-radial (C-R) carotid-dorsalis pedis (C-DP) pulse wave velocity (PWV) aortic characteristic impedance (Zao). Major findings were that normotensive high-normal/hypertensive (HT) Caucasians indicated...
Background The Omron HEM-9000AI is the first automated tonometer to provide an estimate of central SBP (cSBP), which considered be more predictive cardiovascular events than brachial pressure. However, considerable differences between cSBP and that SphygmoCor have been reported, but not explained. This study assesses sources both estimates provides a handle on closest reality. Method For this purpose, aortic derived from calibrated carotid was used as device- algorithm-independent reference....
Background The Finometer (FMS, Finapres Measurement Systems, Arnhem, Netherlands), which is the improved successor of (TNO Biomedical Instrumentation, Amsterdam, measures finger arterial blood pressure non-invasively and computes other cardiovascular parameters from computed aortic-flow waveform. usability would depend on whether it sensitive enough to detect small changes. aim was therefore determine sensitivity regarding acute longer-term Design methods effect 200 mg caffeine determined...
The transition of sub-Saharan Africans from deep rural villages with traditional African lifestyles and diets to an urban westernized milieu, resulted in the prevalence hypertension, vascular disease, end points such as stroke, not just increase, 1 but be highest compared other ethnic groups. 2 This comes no surprise because poor cardiovascular health is a major problem Americans 3,4 who have been for much longer.][7] Despite this, there very little information on factors contributing this...
Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, association between responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) is unknown.Associations BP, silent ischaemia ECG Cornell product LVH were assessed 161 African Caucasian men identified by Amirkhan Coping Strategy Indicator. data obtained from 24-h ambulatory monitoring....
The objective of this study was to make use a quantitative and qualitative approach comparing the systemic renin-angiotensin system (RAS) hypertensive black white African men by using RAS equilibrium analysis.This sub-study involved 23 (n = 15) 8) aged 39.5-41 years, living in North West Province South Africa. RAS-Fingerprinting determined with LC-MS/MS quantification angiotensin peptides. Blood pressure other variables were known methods.The main finding significant lower Ang I (<5.0 45.1...
Impaired baroreflex sensitivity (BRS) is associated with cardiovascular diseases and the metabolic syndrome. Because lipid abnormalities have been impaired BRS, this study aimed to determine whether diets known improve profile, namely a diet high in polyunsaturated fatty acids (walnuts) or monounsaturated (cashew nuts), would BRS subjects syndrome (MS). A controlled feeding trial randomized, controlled, parallel design was undertaken, which involved 62 MS. Subjects were stratified according...
Objective Alarming increases in hypertension and type 2 diabetes among Africans accentuate the need to identify factors that could serve as targets for prevention or treatment. In Caucasian populations, asymmetric dimethylarginine (ADMA), predominant endogenous nitric oxide synthase inhibitor, is associated with cardiovascular disease insulin resistance (IR). ADMA's counterpart, symmetric (SDMA), originally thought be inert, was recently also linked risk. Since little information regarding...