A5078222039- Iron Metabolism and Disorders
- Child Nutrition and Water Access
- Birth, Development, and Health
- Sodium Intake and Health
- Fatty Acid Research and Health
- Metabolism and Genetic Disorders
- Nutritional Studies and Diet
- Folate and B Vitamins Research
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Thyroid Disorders and Treatments
- Obesity, Physical Activity, Diet
- Neonatal Health and Biochemistry
- Trace Elements in Health
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Mitochondrial Function and Pathology
- Peroxisome Proliferator-Activated Receptors
- Blood Pressure and Hypertension Studies
- Helicobacter pylori-related gastroenterology studies
- Blood properties and coagulation
- Food Security and Health in Diverse Populations
- Mycotoxins in Agriculture and Food
- Exercise and Physiological Responses
North-West University
2015-2024
The London College
2024
University Children's Hospital Zurich
2016
University Children’s Hospital Basel
2016
Background Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there a limited understanding population individual-specific cardiovascular pathophysiology – necessary for effective prevention treatment strategies Africa. As lack longitudinal studies tracking early pathophysiological development black populations, African-PREDICT study was...
Adequate nutrition during pregnancy is important to ensure optimal birth outcomes, maternal health and offspring development. However, little known about the dietary intake nutritional status of pregnant women residing in urban South Africa. Therefore, Nutrition Pregnancy Early Development (NuPED) cohort study was initiated assess early nutrition-related exposures predictive childhood development The aims this prospective are: 1) Johannesburg, Africa, 2) determine associations with measures...
Recent studies are suggesting a U-shaped relationship between antenatal iron exposure and birth outcomes. Little is known about the status associated outcomes of pregnant women in South Africa. Our aim was to assess at early, mid- late pregnancy, determine associations with gestational age weight Johannesburg, Africa.In this prospective study 250 women, we measured haemoglobin, biomarkers inflammation <18, 22 36 weeks gestation, plus delivery. Associations anaemia were determined using...
Interleukin-6 (IL-6) induces the expression of fibrinogen, and polymorphic variation within fibrinogen genes is believed to alter magnitude this expression. The identification functional relevance individual single nucleotide polymorphisms (SNPs) has been hindered by high linkage disequilibrium (LD) reported in European gene locus. This study investigated two novel 12 known SNPs potential relevance, 2010 Tswana individuals have low LD. We aimed identify that contribute clot-related...
Abstract The double burden of malnutrition, an emerging concern in developing countries, can exist at various levels: individual, household, and population. Here, we explore the nutritional status Tajik women (15–49 years) children (5–59 months) focusing on overweight/obesity along with undernutrition (underweight, stunting, micronutrient deficiencies). For this, markers (haemoglobin (Hb), transferrin receptor (TfR), serum ferritin (Sf), retinol binding protein (RBP), vitamin D, folate,...
Progressive inflammation and anemia are common in tuberculosis (TB) linked to poor clinical outcomes. Eicosapentaenoic acid (EPA) docosahexaenoic (DHA) have inflammation-resolving properties, whereas iron supplementation TB may limited efficacy enhance bacterial growth. We investigated effects of EPA/DHA supplementation, alone combination, on inflammation, anemia, status markers outcomes Mycobacterium tuberculosis-infected C3HeB/FeJ mice. One week post-infection, mice received the AIN-93...
Universal salt iodization has been adopted by many countries to address iodine deficiency. More recently, salt-reduction strategies have widely implemented meet global intake targets of <5 g/d. Compatibility the two policies yet be demonstrated. This study compares urinary excretion (UIE) according 24-h sodium excretion, between South Africa (SA) and Ghana; both universal iodization, but in Ghana no legislation implemented. Participants from World Health Organization's Study on Global Ageing...
Abstract Adequate intake of iodine is important during pregnancy because its essential role in foetal growth and neurodevelopment. Data on status South African pregnant women are scarce, the salt reduction policy implemented 2016 may decrease Africans. This cross‐sectional study assessed residing urban Johannesburg, Africa. A total 250 were enrolled into ‘Nutrition Pregnancy Early Development’ (NuPED) 312 ‘Assessment dried blood spot thyroglobulin to redefine range median urinary...
Abstract Food fortification with iron nanoparticles (NPs) could help prevent deficiency anemia, but the absorption pathway and biodistribution of iron-NPs their bioavailability in humans is unclear. Dietary non-heme physiologically absorbed via divalent metal transporter-1 (DMT1) pathway. Using radio- isotope labelling mice a partial knockdown intestine-specific DMT1, we assessed oral tissue nanostructured ferric phosphate (FePO 4 -NP; specific surface area [SSA] 98 m 2 g -1 ) compared to...
Perinatal depression can negatively affect the health of mother and her offspring. N-3 polyunsaturated fatty acids (PUFA) may play a role in aetiology depression. Therefore, we investigated association n-3 PUFA status during early pregnancy with perinatal among women living urban Johannesburg, South Africa. For this prospective analysis, analysed red blood cell (RBC) total phospholipid acid (FA) composition (% FA) 242 pregnant at <18 weeks' gestation. We used Edinburgh Postnatal Depression...
Both iron and omega-3 (n-3) fatty acids (FA) play important roles in the development functioning of brain. We investigated effects n-3 FA deficiencies, alone combination, during early on behaviour brain monoamines rats.
Abstract Non-resolving inflammation is characteristic of tuberculosis (TB). Given their inflammation-resolving properties, n -3 long-chain PUFA ( LCPUFA) may support TB treatment. This research aimed to investigate the effects LCPUFA on clinical and inflammatory outcomes Mycobacterium -infected C3HeB/FeJ mice with either normal or low status before infection. Using a two-by-two design, uninfected were conditioned an PUFA-sufficient -3FAS) -deficient -3FAD) diet for 6 weeks. One week...
Elevated homocysteine (Hcy) is associated with several pathologies. Gene-diet interactions related to Hcy might be used customize dietary advice reduce disease incidence. To explore this possibility, we investigated between anthropometry, biochemical markers and diet single-nucleotide polymorphisms (SNPs) in relation concentrations. Five SNPs of Hcy-metabolizing enzymes were analyzed 2010 black South Africans.Hcy was higher each additional methylenetetrahydrofolate reductase (MTHFR) C677T...
Abstract The combined sandwich-ELISA (s-ELISA; VitMin Lab, Germany) and the Quansys Q-Plex™ Human Micronutrient Array (7-Plex) are multiplex serum assays that used to assess population micronutrient status in low-income countries. We aimed compare agreement of five analytes, α -1-acid glycoprotein (AGP), C-reactive protein (CRP), ferritin, retinol-binding 4 (RBP4) soluble transferrin receptor (sTfR) as measured by 7-Plex s-ELISA. Serum samples were collected between March 2016 December 2017....