A5030799402- Global Maternal and Child Health
- Pregnancy and preeclampsia studies
- COVID-19 Impact on Reproduction
- Child and Adolescent Health
- Child Nutrition and Water Access
- Birth, Development, and Health
- Autopsy Techniques and Outcomes
- Neonatal Respiratory Health Research
- Climate Change and Health Impacts
- Pregnancy and Medication Impact
- Iron Metabolism and Disorders
- Maternal and Neonatal Healthcare
- HIV/AIDS Research and Interventions
- Vaccine Coverage and Hesitancy
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive System and Pregnancy
- Sex work and related issues
- Air Quality and Health Impacts
- Milk Quality and Mastitis in Dairy Cows
- T-cell and Retrovirus Studies
- Global Health and Epidemiology
- Animal health and immunology
- Cardiac Structural Anomalies and Repair
- Digital Communication and Language
- Maternal and fetal healthcare
University of the Witwatersrand
2018-2025
Empilisweni District Hospital
2019-2024
Mother Hospital
2022-2024
Health Net
2023
South African Medical Research Council
2023
National Health Laboratory Service
2023
Western Cape Department of Health
2020
The Ohio State University
2002-2003
Delays in illness recognition, healthcare seeking, and the provision of appropriate clinical care are common resource-limited settings. Our objective was to determine frequency delays “Three Delays-in-Healthcare”, factors associated with delays, among deceased infants children seven countries high childhood mortality. We conducted a retrospective, descriptive study using data from verbal autopsies medical records for aged 1–59 months who died between December 2016 February 2022 six sites...
Recent studies are suggesting a U-shaped relationship between antenatal iron exposure and birth outcomes. Little is known about the status associated outcomes of pregnant women in South Africa. Our aim was to assess at early, mid- late pregnancy, determine associations with gestational age weight Johannesburg, Africa.In this prospective study 250 women, we measured haemoglobin, biomarkers inflammation <18, 22 36 weeks gestation, plus delivery. Associations anaemia were determined using...
<ns3:p>Introduction Epidemiological evidence linking heat exposure to adverse maternal and child health outcomes is compelling. However, the biological social mechanisms underlying these associations remain poorly understood. Understanding pathways explaining important given rising global temperatures, urgent need for developing testing adaptive interventions. Methods This transdisciplinary study in Johannesburg, South Africa, will monitor a cohort of 200 women from their second trimester...
Repeated monitoring of viral load (VL) among pregnant women living with HIV (WLWH) is critical in vertical transmission prevention. For who are newly diagnosed during pregnancy, a subsequent VL recommended three months after ART initiation, and for all HIV, follow-up required every six throughout pregnancy breastfeeding [2]. Here, we describe the uptake timing testing frequency distribution viraemic episodes pregnancy. We linked prospective cohort data from WLWH whose infants were born at...
Neural tube defects are common birth resulting in severe morbidity and mortality; they can largely be prevented with periconceptional maternal intake of folic acid. Understanding the occurrence neural their contribution to mortality settings where burden is highest could inform prevention health-care policy. We aimed estimate attributed seven countries sub-Saharan Africa southeast Asia.
Invasive Group B Streptococcus (GBS) is a common cause of early-onset neonatal sepsis and also associated with stillbirth. This study aimed to determine the proportion stillborn infants who died between 0 90 days attributable GBS using postmortem minimally invasive tissue sampling (MITS) in 7 low- middle-income countries (LMICs) participating Child Health Mortality Prevention Surveillance (CHAMPS). Deaths that occurred December 2016 2021 were investigated MITS, including culture for bacteria...
Importance The emergence of acute neurological symptoms in children necessitates immediate intervention. Although low- and middle-income countries (LMICs) bear the highest burden diseases, there is a scarcity diagnostic therapeutic resources. Therefore, current understanding etiology emergencies LMICs relies mainly on clinical diagnoses verbal autopsies. Objective To characterize association premortem their management with postmortem-confirmed cause death among aged younger than 5 years to...
Current point-of-care tests (POCT) for syphilis, based on the detection of
Most childhood deaths globally are considered preventable through high-quality clinical care, which includes adherence to care recommendations. Our objective was describe World Health Organization recommendations for the management of leading causes death among children.We conducted a retrospective, descriptive study examining data children aged 1-59 months who were hospitalized and died in Child Mortality Prevention Surveillance (CHAMPS) catchment, December 2016-June 2021. Catchment areas...
Abstract Adequate intake of iodine is important during pregnancy because its essential role in foetal growth and neurodevelopment. Data on status South African pregnant women are scarce, the salt reduction policy implemented 2016 may decrease Africans. This cross‐sectional study assessed residing urban Johannesburg, Africa. A total 250 were enrolled into ‘Nutrition Pregnancy Early Development’ (NuPED) 312 ‘Assessment dried blood spot thyroglobulin to redefine range median urinary...
Urinary tract infection (UTI) in pregnancy is associated with significant morbidity for both the mother and foetus. The aim of this study was to determine prevalence UTI, urinary bacterial susceptibility, resistance patterns among pregnant women a possible UTI at Rahima Moosa Mother Child Hospital (RMMCH) Johannesburg.In retrospective study, we analysed mid-stream urine culture antibiotic susceptibility data from inpatients outpatients who attended RMMCH January 2017 December 2017. Data were...
Influenza vaccination during pregnancy reduces influenza-associated illness in the women and their infants, but effectiveness estimates against hospitalization are limited lacking from settings with high human immunodeficiency virus (HIV) infection prevalence. We assessed effect of maternal HIV-uninfected HIV preventing hospitalizations infants women. During 2015-2018, influenza campaigns targeting pregnant were augmented at selected antenatal clinics; these coupled prospective...
Purpose The Rahima Moosa Mother and Child Hospital (RMMCH) maternal HIV cohort originated from data systems that were developed to support HIV-related birth care track outcomes of a complete HIV-exposed infants at their mothers living with HIV. Participants Supported by the Empilweni Services Research Unit, infant 13 654 pregnant women who delivered (and subset also attended antenatal care) collected RMMCH in Johannesburg, South Africa since 2013. Maternal using counsellor-administered...
Antibiotic resistance is a global threat, with disproportionate burden of mortality in low- and middle-income countries. It increasing both the public private healthcare sectors within South Africa, especially Gram-negative organisms, associated increased use World Health Organization watch reserve antibiotics. There need for improved access to new antibiotics treat infections caused by drug-resistant organisms order limit side-effects improve patient outcomes currently available We propose...
SARS-CoV-2 infection in pregnant women has been associated with severe illness the and higher rates of premature delivery. There is, however, paucity data on impact timing symptomatic or asymptomatic infections birth outcomes. Data from low-middle income settings is also lacking.
Melnick‐Needles syndrome (MNS; MIM 309350) is an X‐linked skeletal dysplasia caused by mutations in FLNA . Females with the condition present characteristic facial features, short stature, anomalies, including poorly modeled and sclerotic bones, structural abnormalities such as cardiac urological defects. Previously males were thought to either a mild phenotype compatible life or severe lethal presentation depending on maternal phenotype. The discovery of limited number cause has clarified...
Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy has been associated with poor outcomes. There is, however, not much information on the impact of timing SARS-CoV-2 outcomes, and studies from low-middle income settings are also scarce.We conducted a cross-sectional study April to December 2020, in South Africa, assess association nasal swab at time labor fetal death, preterm birth, low birth weight, or pregnancy-induced complications. When possible,...
<title>Abstract</title> Background Antenatal iron deficiency (ID) and anaemia, but also elevated ferritin haemoglobin (Hb) have been associated with morbidity during pregnancy. In South Africa, pregnant women receive routine supplementation for anaemia prevention regardless of status. Our aim was to assess whether status at early pregnancy is infectious Methods This prospective cohort conducted in 250 a public maternal child hospital Johannesburg, Africa. Biomarkers < 18 weeks’ gestation...