A5062087276- Iron Metabolism and Disorders
- Child Nutrition and Water Access
- Fatty Acid Research and Health
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Nutritional Studies and Diet
- Trace Elements in Health
- Folate and B Vitamins Research
- Neonatal Health and Biochemistry
- Diet and metabolism studies
- Hemoglobinopathies and Related Disorders
- Obesity, Physical Activity, Diet
- Infant Nutrition and Health
- Food Security and Health in Diverse Populations
- Sodium Intake and Health
- HIV-related health complications and treatments
- Vitamin D Research Studies
- Pregnancy and preeclampsia studies
- Breastfeeding Practices and Influences
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- HIV/AIDS Research and Interventions
- Gestational Diabetes Research and Management
- Plant Micronutrient Interactions and Effects
- Liver Disease Diagnosis and Treatment
ETH Zurich
2010-2024
North-West University
2015-2024
King's College London
2022-2024
Medical University of Graz
2024
King's College Hospital
2024
Commonwealth Fund
2020
Clinical Nutrition Research Centre
2017
University Hospital Southampton NHS Foundation Trust
2015
National Health Service
2015
University of Southampton
2015
Fe supplementation is a common strategy to correct Fe-deficiency anaemia in children; however, it may modify the gut microbiota and increase risk for enteropathogenic infection. In present study, we studied impact of on abundance dominant bacterial groups gut, faecal SCFA concentration inflammation children living rural South Africa. randomised, placebo-controlled intervention trial 38 weeks, 6- 11-year-old with deficiency received orally either tablets containing 50 mg as FeSO 4 ( n 22)...
Adequate nutrition during pregnancy is important to ensure optimal birth outcomes, maternal health and offspring development. However, little known about the dietary intake nutritional status of pregnant women residing in urban South Africa. Therefore, Nutrition Pregnancy Early Development (NuPED) cohort study was initiated assess early nutrition-related exposures predictive childhood development The aims this prospective are: 1) Johannesburg, Africa, 2) determine associations with measures...
Recent studies are suggesting a U-shaped relationship between antenatal iron exposure and birth outcomes. Little is known about the status associated outcomes of pregnant women in South Africa. Our aim was to assess at early, mid- late pregnancy, determine associations with gestational age weight Johannesburg, Africa.In this prospective study 250 women, we measured haemoglobin, biomarkers inflammation <18, 22 36 weeks gestation, plus delivery. Associations anaemia were determined using...
Distinguishing arginine vasopressin (AVP) deficiency from primary polydipsia remains challenging. While hypertonic saline-stimulated copeptin testing offers high diagnostic accuracy, it is complex and limited to specialized centers. Intravenous urea known stimulate AVP secretion, but the effect of oral on levels unknown. 22 healthy adults were included in a randomized, double-blind, placebo-controlled cross-over trial receiving single dose (0.5 g/kg; minimum 30 g, maximum 45 g) placebo....
Little is known about the effects of combined micronutrient and sugar consumption on growth cognition. In present study, we investigated micronutrients sugar, alone in combination, a beverage cognition schoolchildren. 2 × factorial design, children ( n 414, 6–11 years) were randomly allocated to consume beverages containing (1) with (2) non-nutritive sweetener, (3) no or (4) sweetener for 8·5 months. Growth was assessed tested using Kaufman Assessment Battery Children version II (KABC-II)...
Background: Breast milk iodine concentration (BMIC) may be an indicator of status during lactation, but there are few data comparing different analytical methods or timing sampling. The aims this study were: (i) to optimize a new inductively coupled plasma mass spectrometry (ICP-MS) method; and (ii) evaluate the effect method within-feed sample collection on BMIC. Methods: colorimetric Sandell–Kolthoff was evaluated with (a) without (b) alkaline ashing, ICP-MS using 129I isotope ratio...
Abstract Zn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. supplementation affects the desaturases of Zn-deficient rats, but whether this occurs humans is unclear. We evaluated associations between baseline plasma (PZn) concentration total phospholipid composition, well effect daily consumption Zn-fortified water on Beninese children. A 20-week, double-blind randomised controlled trial was conducted 186 school age The...
Abstract Accumulating evidence indicates that saturated fat intake is related to mortality risk increase, whereas unsaturated associated with reduced risk. The aim of the present study was estimate reduction a dietary change from mono- or polyunsaturated intake. American National Health and Nutrition Examination Surveys conducted between 1999 2010 were linked 2011 national US death registry resulting in an observational prospective study. Proportional hazards Cox models used evaluate...
Human immunodeficiency virus (HIV) and iron deficiency (ID) affect many African children. Both HIV status interact with gut microbiota composition related biomarkers. The study's aim was to determine the associations of composition, inflammation integrity in South school-age
Introduction Attempting to curb the rising epidemic of hypertension, South Africa implemented legislation in June 2016 mandating maximum sodium levels a range manufactured foods that contribute significantly population salt intake. This natural experiment, comparing two African countries with and without legislation, will provide timely information on impact legislative approaches addressing food supply improve blood pressure populations. article outlines design this ongoing prospective...
Lactating women and their infants are susceptible to iodine deficiency excess. In South Africa, no data exist on the status thyroid function of these vulnerable groups.
Research Objective The insurance coverage expansions enacted through the Affordable Care Act have significantly increased access to health care since main provisions went into effect in 2014. This study analyzes degree which narrowed racial and ethnic disparities between white adults black Hispanic adults. It also aims examine differences states that expanded Medicaid eligibility those not, while highlighting policy options might further reduce groups. Study Design Data for this come from...
The WHO's global targets for non-communicable disease reduction recommend consumption of<5 g salt/day. In 2016, South Africa was the first country to legislate maximum salt levels in processed foods. Africa's iodisation fortification programme has successfully addressed iodine deficiency but information is dated. Simultaneous monitoring of sodium and status required ensure compatibility two public health interventions. A nested cohort design within 2015 Study on AGEing adult (n=2887)...
Observational studies suggest a link between n-3 polyunsaturated fatty acid (PUFA) intake, PUFA status, and depression in adults, but adolescents are scarce. This study aimed to determine associations of status intake with paediatric major depressive disorder (pMDD) Swiss adolescents.We conducted matched case-control 95 diagnosed pMDD healthy controls aged 13 <18 years. We analysed red blood cell (RBC) (FA) composition (% total FA). was assessed using focused food frequency questionnaire...