A5105159342- Blood Pressure and Hypertension Studies
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Disease and Adiposity
- Sodium Intake and Health
- Obesity, Physical Activity, Diet
- HIV-related health complications and treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Nutritional Studies and Diet
- Hormonal Regulation and Hypertension
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Ion channel regulation and function
- Renin-Angiotensin System Studies
- Cardiac Health and Mental Health
- Birth, Development, and Health
- Diet, Metabolism, and Disease
- Global Public Health Policies and Epidemiology
- Growth Hormone and Insulin-like Growth Factors
- Cardiovascular Health and Risk Factors
- Hormonal and reproductive studies
- Venomous Animal Envenomation and Studies
- Cardiovascular Function and Risk Factors
North-West University
2013-2022
South African Medical Research Council
2016-2021
Nutrition Sciences (Belgium)
2006
University of Limpopo
1996
Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals with optimal blood pressure (BP) (≤120/80 mm Hg), their 5-year prediction for the development hypertension. Methods The Prospective Urban Rural Epidemiology study North West Province, South Africa, started 2005 included volunteers (n = 1994; aged > 30 years) from a...
Background Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there a limited understanding population individual-specific cardiovascular pathophysiology – necessary for effective prevention treatment strategies Africa. As lack longitudinal studies tracking early pathophysiological development black populations, African-PREDICT study was...
Abstract Dyslipidemia has been documented worldwide among human immunodeficiency virus‐infected (HIV) individuals and these changes are reminiscent of the metabolic syndrome (MetS). In South Africa, with highest number HIV infections worldwide, HIV‐1 subtype C is prevalent, while B (genetically different from C) prevails in Europe United States. We aimed to evaluate if infection (subtype associated dyslipidemia, inflammation occurrence MetS Africans. Three hundred newly diagnosed...
In Africans, arterial stiffness progression seems more pronounced compared to Caucasians. We the profiles of different age groups and focused on muscular arteries two central segments in African Caucasian people from South Africa. (N = 374) 376) participants (20–70 years), we measured carotid-radial (C-R) carotid-dorsalis pedis (C-DP) pulse wave velocity (PWV) aortic characteristic impedance (Zao). Major findings were that normotensive high-normal/hypertensive (HT) Caucasians indicated...
Background The Omron HEM-9000AI is the first automated tonometer to provide an estimate of central SBP (cSBP), which considered be more predictive cardiovascular events than brachial pressure. However, considerable differences between cSBP and that SphygmoCor have been reported, but not explained. This study assesses sources both estimates provides a handle on closest reality. Method For this purpose, aortic derived from calibrated carotid was used as device- algorithm-independent reference....
BackgroundExcessive alcohol intake is a risk factor for cardiovascular disease (CVD) and predicts all-cause mortality. We determined which marker (self-reported intake, gamma-glutamyltransferase (GGT) or percentage carbohydrate deficient transferrin (%CDT)) relates best with mortality hypertension development over five years in black South Africans.
Background The Finometer (FMS, Finapres Measurement Systems, Arnhem, Netherlands), which is the improved successor of (TNO Biomedical Instrumentation, Amsterdam, measures finger arterial blood pressure non-invasively and computes other cardiovascular parameters from computed aortic-flow waveform. usability would depend on whether it sensitive enough to detect small changes. aim was therefore determine sensitivity regarding acute longer-term Design methods effect 200 mg caffeine determined...
The transition of sub-Saharan Africans from deep rural villages with traditional African lifestyles and diets to an urban westernized milieu, resulted in the prevalence hypertension, vascular disease, end points such as stroke, not just increase, 1 but be highest compared other ethnic groups. 2 This comes no surprise because poor cardiovascular health is a major problem Americans 3,4 who have been for much longer.][7] Despite this, there very little information on factors contributing this...
Defensive active coping responses (being-in-control, acceptance of the stressor as reality) have been associated with vascular hyper-responsiveness in urban Africans. However, association between responses, blood pressure (BP), and ECG-derived left-ventricular hypertrophy (LVH) is unknown.Associations BP, silent ischaemia ECG Cornell product LVH were assessed 161 African Caucasian men identified by Amirkhan Coping Strategy Indicator. data obtained from 24-h ambulatory monitoring....
Objective Alarming increases in hypertension and type 2 diabetes among Africans accentuate the need to identify factors that could serve as targets for prevention or treatment. In Caucasian populations, asymmetric dimethylarginine (ADMA), predominant endogenous nitric oxide synthase inhibitor, is associated with cardiovascular disease insulin resistance (IR). ADMA's counterpart, symmetric (SDMA), originally thought be inert, was recently also linked risk. Since little information regarding...
Heart failure in the African population is reaching alarming levels. Increased afterload as a result of increased vasoconstriction during stress may lead to impaired ventricular function and stroke volume (SV) well vascular hypertrophy. In this study, we challenged cardiovascular system order evaluate possible contribution indicators α-adrenergic (i.e., resistance SV reactivity) on left mass carotid intima-media thickness (CIMT) Caucasian men. We evaluated 101 male schoolteachers. Ambulatory...