A5004456982- HIV-related health complications and treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- Global Public Health Policies and Epidemiology
- Nitric Oxide and Endothelin Effects
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Hormonal Regulation and Hypertension
- Cardiovascular Syncope and Autonomic Disorders
- Gout, Hyperuricemia, Uric Acid
- Metabolomics and Mass Spectrometry Studies
- Obesity, Physical Activity, Diet
- HIV/AIDS drug development and treatment
- Renin-Angiotensin System Studies
- HIV/AIDS Impact and Responses
- Vitamin D Research Studies
- Protease and Inhibitor Mechanisms
- Growth Hormone and Insulin-like Growth Factors
North-West University
2010-2023
Medical Research Council
2018
Background Longitudinal cohort studies in sub-Saharan Africa are urgently needed to understand cardiovascular disease development. We, therefore, explored health behaviours and conventional risk factors of African individuals with optimal blood pressure (BP) (≤120/80 mm Hg), their 5-year prediction for the development hypertension. Methods The Prospective Urban Rural Epidemiology study North West Province, South Africa, started 2005 included volunteers (n = 1994; aged > 30 years) from a...
Introduction: Left ventricular geometry is associated with cardiovascular events and prognosis.The Tei index of myocardial performance a combined systolic diastolic dysfunction has been shown to be predictor outcome in heart diseases.The relationship between the left not well studied.This study examined association among hypertensive Nigerian subjects.Methods: We performed echocardiography on 164 hypertensives 64 control subjects.They were grouped into four geometric patterns based mass...
People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection HIV contributes development of CVD independent traditional risk factors, endothelial dysfunction being central physiological mechanism. While HIV-related mortality is declining due antiretroviral treatment (ART), number deaths rising in South Africa - country highest PLHIV and world's largest ART programme. The...
Increasing evidence suggests that L-homoarginine, an endogenous analogue of the amino acid L-arginine, may have beneficial effects on vascular homeostasis. We examined whether L-homoarginine is associated with 10-year risk all-cause and cardiovascular mortality in a black South African population.We included 669 participants (mean age 59.5 years), 143 whom died during follow-up period. Mortality data were acquired via verbal autopsy. Plasma (and other related markers) analysed liquid...
Background Anti-retroviral therapy (ART) regimes for HIV are associated with raised levels of circulating triglycerides (TGs) in western populations. However, there limited data on the impact ART cardiometabolic risk sub-Saharan African (SSA) Methods Pooled analyses 14 studies comprising 21 023 individuals, whom relevant factors (including TG), and status were assessed between 2003 2014, SSA. The association TG (>2.3 mmol/L) was analysed using regression models. Findings Among 10 615 a...
The human immunodeficiency virus (HIV) is often accompanied by renal dysfunction. It expected that metabolic syndrome (MetS) may exacerbate impairment.We therefore determined the prevalence of MetS and association thereof with function in a South African cohort infected HIV.We matched 114 HIV-infected (77.3% on antiretroviral therapy [ART] 22.7% ART-naïve) HIV-uninfected individuals according to age, sex locality. We examined cardiovascular, anthropometric measurements MetS. Renal was...
Chronic inflammation is an HIV infection feature, contributing to elevated risk of cardiovascular disease among people with HIV, which can be induced by viral replication. A proportion antiretroviral therapy (ART) recipients fail achieve suppression, despite not meeting criteria for treatment failure, so-called low-level viremia (LLV). We investigated the relationship between LLV and array measures biomarkers. South Africans (viral load = 50−999 copies/mL) virological suppression <50 were...
BackgroundThe increasing prevalence of hypertension and vascular-related morbidity mortality among Africans emphasizes the need to identify markers for early detection vascular disease. Caucasian-based studies demonstrate that von Willebrand factor (vWf) is a useful marker dysfunction. We investigated whether associations between this cardiovascular function in Caucasian women are comparable with African women.
Background: As the life expectancy of people living with HIV increases because antiretroviral treatment (ART), their risk for vascular co-morbidities and early ageing (EVA) also increases.Objective: We aimed to investigate whether infection relates structure function in black South African adults this relationship is age dependent.Method: This cross-sectional study carried out urban rural areas North West province, Africa, included 572 age- sex-matched (PLWH) without HIV. Participants from...
Objective: Elevated inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) are well-known risk factors for cardiovascular mortality. The less familiar marker, soluble urokinase plasminogen activator receptor (suPAR), is known to predict cancer, infections all-cause We determined whether suPAR, CRP IL-6 predictive of both mortality in a black population, highly burdened by disease HIV infection. Design method: included 1 425 South Africans, which 208 died within five...
Objectives We aimed to determine whether people with human immunodeficiency virus (PWHIV) have increased measures of arterial injury [carotid intima‐media thickness (cIMT)] and large artery stiffness [carotid‐femoral pulse wave velocity (cfPWV)] when compared their counterparts without HIV, baseline markers endothelial activation cardiovascular risk are associated cIMT cfPWV after 5 years. Methods matched 126 PWHIV from North West Province, South Africa, HIV according age, sex locality....
Objective: Chronic elevations in uric acid can be linked to cardiovascular risk factors. The aim of this study was see if factors have a relationship with levels urbanised black Africans and compare differences between men women. Design Methods: Two hundred subjects (aged 25–60 years; 50% women) participated target population an African population. Ambulatory blood pressure, pulse wave velocity (PWV), carotid intima media thickness (CIMT) were measured. Cross sectional wall area (CSWA)...
Objective: Tetrahydrobiopterin (BH4) is a cofactor for nitric oxide synthase (NOS) and may be critical agent in endothelial function by improving (NO) mediated effects. It reported that the NO synthesis capacity seems favourable blacks despite their adverse cardiovascular profile. We therefore compared concentrations of BH4, as well blood pressure (BP) arterial stiffness between black white teachers. Furthermore, we tested associations BH4 with product inhibitor synthesis, namely...
Purpose Hypertension, obesity, hyperlipidemia, and type 2 diabetes contribute primarily to noncommunicable disease deaths together with human immunodeficiency virus largely mortality in South Africa. Our longitudinal study provides the necessary data insights over a 10-year period highlight areas where improved management is required urban rural localities. Methods This included 536 387 Black participants aged 32 93 years from North-West province, Disease prevalence, treatment, control were...
Objective: Low serum insulin-like growth factor-1 (IGF-1) is an independent risk factor for cardiovascular disease and diabetes. These noncommunicable diseases are extremely common in urban black South Africans, but their IGF-1 concentration unknown. We aimed to compare concentrations of African Caucasian people; investigate age-related decline determine whether could account, at least part, the high prevalence Africans. Design Methods: This cross-sectional study involved 211 316 men women...
Abstract Background: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection HIV contributes development of CVD independent traditional risk factors, endothelial dysfunction being central physiological mechanism. While HIV-related mortality is declining due antiretroviral treatment (ART), number deaths rising in South Africa - country highest PLHIV and world’s largest ART...
Abstract Background: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection HIV contributes development of CVD independent traditional risk factors, endothelial dysfunction being central physiological mechanism. While HIV-related mortality is declining due antiretroviral treatment (ART), number deaths rising in South Africa - country highest PLHIV and world’s largest ART...
Abstract Background: People living with the Human Immunodeficiency Virus (PLHIV) have an increased susceptibility to develop non-communicable diseases such as cardiovascular disease (CVD). Infection HIV contributes development of CVD independent traditional risk factors, endothelial dysfunction being central physiological mechanism. While HIV-related mortality is declining due antiretroviral treatment (ART), number deaths rising in South Africa - country highest PLHIV and world’s largest ART...