A5003523384- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Ocular Surface and Contact Lens
- Ocular Disorders and Treatments
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Infections and Treatments
- Retinal Development and Disorders
- Retinal and Macular Surgery
- Photoreceptor and optogenetics research
- Traumatic Ocular and Foreign Body Injuries
- Photochromic and Fluorescence Chemistry
- Mitochondrial Function and Pathology
- Ocular and Laser Science Research
- DNA Repair Mechanisms
- Herpesvirus Infections and Treatments
- Light effects on plants
- Advanced Radiotherapy Techniques
- Ultrasound Imaging and Elastography
- Facial Trauma and Fracture Management
- PI3K/AKT/mTOR signaling in cancer
- bioluminescence and chemiluminescence research
- Virus-based gene therapy research
- Animal Virus Infections Studies
- Ophthalmology and Visual Impairment Studies
Illinois College
2019-2025
University of Illinois Chicago
2016-2025
Visual Sciences (United States)
2017-2025
New York Eye and Ear Infirmary
2012-2025
Research to Prevent Blindness
2014-2022
National Institutes of Health
2022
University of Illinois Urbana-Champaign
2011-2020
Prevent Blindness
2014-2018
Centre Hospitalier Universitaire de Tours
2017
University of Chicago Medical Center
2015-2017
This study was conducted to define whether pigment epithelial-derived growth factor (PEDF), together with docosahexaenoic acid (DHA), enhances the synthesis of neuroprotectin D1 (NPD1) and regeneration corneal nerves damaged after surgery.Corneal stromal dissection performed in left eyes adult New Zealand rabbits treated DHA+PEDF, PEDF, or DHA for 6 weeks. In vivo confocal images corneas were obtained at 2, 4, 8 weeks, nerve areas quantified. At weeks treatment, stained tubulin betaIII...
To report the short-term visual outcomes and complications of keratoprosthesis surgery as primary penetrating corneal procedure for patients at high risk conventional transplantation.A retrospective chart review was conducted 21 eyes 19 who underwent either Boston type I or II from February 2007 to March 2011.Nineteen (90.5%) 2 (9.5%) procedures were performed in patients. Mean follow-up 14.6 months (range, 6-36.3 mo). Primary indications included chemical thermal injury, aniridia,...
To assess function of regenerated corneal nerves in correlation with epithelial wound healing after experimental nerve damage rabbits treated pigment epithelial-derived factor (PEDF) plus docosahexaenoic acid (DHA).An 8-mm stromal dissection was performed the right eyes adult New Zealand rabbits. Treatment PEDF+DHA for 6 weeks. Corneal sensation measured weekly by Cochet-Bonnet esthesiometer. After 8 weeks, immunofluorescence βIII-tubulin, calcitonin gene-related peptide, and substance P...
To investigate if topical treatment of neuroprotectin D1 (NPD1) increases regeneration functional nerves after lamellar keratectomy.An 8-mm stromal dissection was performed in the left eye each rabbit. The rabbits were treated with NPD1, pigment epithelial-derived factor (PEDF) combination docosahexaenoic acid (DHA) or vehicle for 6 weeks, and corneas obtained at 8 weeks. After fixation, corneal wholemounts stained mouse monoclonal anti-βIII-tubulin antibody double chicken anti-calcitonin...
To report the indications, postoperative visual outcomes, and long-term graft survival of primary pediatric keratoplasties performed at a single tertiary care center. We conducted retrospective review patients (16 years younger) who underwent surgical intervention for corneal opacity center to evaluate rehabilitation. Seventy-three eyes 46 met inclusion criteria. The mean patient age time transplantation was 7.44 (range, 5 months-15.72 years), average follow-up 5.82 years. Forty (56%) had...
Purpose: To report clinical outcomes of cyanoacrylate glue patches in managing corneal melting keratoprosthesis (KPro). Methods: Multicenter, retrospective, noncontrolled, interventional case series. Subjects underwent for melt after KPro implantation, regardless the underlying cause, design, or severity. Clinical success was defined as resolving aqueous leak, halting further melting, and avoiding carrier graft exchange at least 12 months patch application. Results: Sixteen eyes 15 patients...
Purpose.: To compare a 44-mer pigment epithelial–derived factor (PEDF) peptide with neurotrophic activity, and 34-mer PEDF antiangiogenic properties in association docosahexaenoic acid (DHA) corneal nerve regeneration after experimental surgery. Methods.: A stromal dissection was performed rabbits. Treatment groups received topical 44-mer, 34-mer, or full plus DHA. Corneal sensitivity Schirmer's test were weekly. Rabbits euthanized at 2 4 days 8 weeks. Two- 4-day samples stained for...
To analyze iris behavior and angle status using serial anterior segment optical coherence tomography (AS-OCT) after Boston keratoprosthesis (KPro).A prospective cases series consisted of 11 eyes with implanted type 1 KPro at a tertiary care institution. The patients underwent preoperative postoperative AS-OCT imaging. main outcome measures included chamber (ACA) representative meridians (0 degrees, 45 90 135 180 225 270 315 degrees), grading total ACA as open (>10 shallow (≥1 degrees ≤10...
Despite improved retention and reduced complication rates paving the way for current expansion of applications surge in prevalence Boston type I Keratoprosthesis (KPro), most frequent indication its implantation today remains prior graft failure. The purpose this study is to evaluate long-term outcomes primary KPro compare secondary a matched cohort study. This included patients who underwent single center by two surgeons between July 2008 October 2014. All eyes with as procedure minimum...
Herpes simplex virus type-1 (HSV-1) infection leads to impaired corneal sensation and, in severe cases, ulceration, melting and perforation. Here, we explore the potential therapeutic action of pigment epithelial-derived factor (PEDF) plus docosahexaenoic acid (DHA) on inflammation nerve regeneration following HSV-1 infection. Rabbits inoculated with 100,000 PFU/eye strain 17Syn+ were treated PEDF + DHA or vehicle. treatment resulted a biphasic immune response stronger infiltration CD4+T...
Purpose: Glaucoma drainage implantation in conjunction with Boston Type 1 Keratoprosthesis placement is a surgical option controlling postoperative glaucoma. The purpose of this study to report outcomes combined pars plana vitrectomy and glaucoma corneal patch graft patients. Patients Methods: A retrospective review patients who underwent combination was performed. Preoperative parameters collected analyzed included: visual acuity, intraocular pressure, number medications achieve pressure...