A5102949461- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Dermatologic Treatments and Research
- Ocular Diseases and Behçet’s Syndrome
- Long-Term Effects of COVID-19
- Bacterial Identification and Susceptibility Testing
- Reconstructive Facial Surgery Techniques
- Acne and Rosacea Treatments and Effects
- Traumatic Ocular and Foreign Body Injuries
- Herpesvirus Infections and Treatments
- Facial Rejuvenation and Surgery Techniques
- Toxoplasma gondii Research Studies
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- COVID-19 and healthcare impacts
- Nerve Injury and Rehabilitation
- SARS-CoV-2 and COVID-19 Research
- Optical Imaging and Spectroscopy Techniques
- Facial Nerve Paralysis Treatment and Research
- Pediatric health and respiratory diseases
University of Minnesota
2016-2025
Minnesota Lions Eye Bank
2018-2023
University of Minnesota System
2021-2023
University of Illinois Chicago
2011-2016
New York Eye and Ear Infirmary
2012-2016
Universidade Federal de São Paulo
2015
Rush University
2014
Visual Sciences (United States)
2012
University of Illinois Urbana-Champaign
2011-2012
Duke University Hospital
2006
Purpose: To confirm the ocular tropism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by evaluating expression viral entry factors in human tissues using immunohistochemistry. Methods: Fresh donor corneas and primary explant cultures corneal, limbal, conjunctival epithelial cells were evaluated for factors. Using immunohistochemistry, samples tested angiotension-converting enzyme (ACE2), dendritic cell–specific intracellular adhesion molecule 3-grabbing nonintegrin...
Purpose: In patients referred with blepharoptosis, the possibility of an underlying systemic cause for their ptosis can warrant a more detailed evaluation. The purpose this study is to determine both incidence and demographic characteristics associated different types in oculoplastics division at tertiary care center.Methods: A retrospective chart review was performed on all between 2007 2010. Final etiology each patient's determined based history, standard eyelid measurements, ancillary...
The aim of this study was to report the successful medical management 2 cases late-onset endothelial keratoplasty-related stromal interface infections.All infections treated with intrastromal antifungal injections were compiled. following information collected: demographic data, surgical indications, donor rim cultures, mate outcomes, clinical course, diagnostic tests, and outcome.Two fungal keratitis diagnosed on appearance confocal microscopy identified. Both patients refused undergo...
To describe and report outcomes of our single-pass microkeratome technique for preparation ultrathin (UT, ≤100 μm) nanothin (NT, ≤50 Descemet stripping automated endothelial keratoplasty (DSAEK) grafts.To prepare NT-DSAEK grafts, a pachymetry nomogram specific to each technician individual head was developed based on accumulated precut postcut data from previous DSAEK grafts. Mean graft thickness as well cell counts (ECCs) NT-DSAEK, UT-DSAEK, membrane (DMEK) grafts between July 2015 2017...
Purpose: To evaluate factors that contribute to keratoplasty failure after keratolimbal allograft (KLAL) and report the outcomes of Boston keratoprosthesis type I (KPro) as salvage therapy. Methods: Retrospective noncomparative case series 7 eyes in consecutive patients with ocular surface disease limbal stem cell deficiency treated KPro failed KLAL. Mechanisms graft failure, device retention rate, preoperative postoperative best-corrected visual acuities were studied. Results: In studied...
Retroprosthetic membrane (RPM) formation is the most common complication associated with Boston type 1 keratoprosthesis and has been corneal melt.To identify histological immunohistochemical characteristics of RPMs melt.Observational histopathological case series at a tertiary eye care referral center among patients who underwent explantation because donor melt Illinois Eye Ear Infirmary between January 1, 2011, 2012.Seven RPM specimens from 7 eyes were stained hematoxylin-eosin, cytokeratin...
Corneal perforation is a rare, vision-threatening complication of ocular graft-versus-host disease (GVHD) and not well understood. Our objective was to examine the clinical course histopathologic correlation in patients who progressed this outcome.This study retrospective case series from four academic centers United States. All received hematopoietic stem cell transplant (HSCT) prior developing GVHD. Variables interest included patient demographics, time interval between HSCT events, visual...
To determine the rate of biofilm formation on bandage contact lenses worn by patients with Boston type 1 keratoprosthesis (K-Pro) while prophylactic topical vancomycin versus linezolid.Patients wearing a lens (BCL) K-Pro were eligible for enrollment. After irrigation ocular surface 5% povidone-iodine solution, each patient was placed either 15 mg/mL or linezolid 0.2% BID one month. At one-month visit, BCL collected and stored in fixative solution. Standard photographs taken at high...
Purpose: The purpose of this study was to describe the use Descemet membrane anterior keratoplasty (DMAK) with modified allogeneic simple limbal epithelial transplantation treat a case partial stem cell deficiency (LSCD) following keratolimbal allograft failure. Methods: Case report. Results: A 21-year-old woman autoimmune polyglandular syndrome–related LSCD presented pain and decreased vision. There failure recurrence after severe/acute rejection that led persistent defects refractory...
Aim To evaluate the prevalence and clinical characteristics of limbal stem cell deficiency (LSCD) in setting a tertiary referral cornea practice at an academic center. Patient methods A retrospective chart review was performed to identify all unique medical record numbers (MRNs) presenting single specialist (JHH) University Minnesota during calendar years 2019 2020. Records were queried confirmed for diagnosis LSCD. Clinical identified patients, including demographics, etiology LSCD,...
To describe the morphological distribution of host tissue and microbial biofilms on intraocular surfaces Boston type I keratoprostheses (KPros) explanted because corneal melt.Retrospective study scanning electron microscopy (SEM) images from 4 KPros composed polymethylmethacrylate titanium. SEM KPro-associated ocular were reviewed for presence inflammatory cells, microbes, and/or biofilm formation. One sterile KPro was also imaged to serve as a (device only) control.All culture-negative,...
The purpose of the study was to evaluate, as a pilot trial, safety and tolerability CAM-101 10% 30% topical ophthalmic fibrinogen-depleted human platelet lysate (FD hPL) solution in patients with dry eye disease (DED) secondary graft-versus-host (GvHD) after 6 weeks treatment.A phase I/II, pilot, prospective, multicenter, randomized, double-masked clinical trial.Patients DED GvHD.Sixty-four adult were stratified by "symptom severity" (Ocular Surface Disease Index [OSDI], ocular discomfort...
We describe a technique for image-guided femtosecond laser–assisted cataract surgery in case of Peters anomaly type 2. The laser technology enabled reliable construction complete capsulotomy despite central corneal opacification and tented anterior capsule. Use an extraction 2 is safe method removing these complex cataracts while preserving capsular integrity. Financial Disclosure Dr. De la Cruz consultant to Alcon Surgical, Inc. No other author has financial or proprietary interest any...
The aim of this study was to report the persistent staining corneal lattice lines resulting from intraoperative use trypan blue.This is a case series.Four patients with dystrophy (LCD) who underwent either deep anterior lamellar keratoplasty or cataract extraction blue demonstrated persistent, postoperative on slit-lamp examination out final follow-up (range, 176 541 days postoperatively).This series demonstrates previously unreported finding that stains in LCD. Trypan staining, localized...
To report the postoperative clinical course of 3 patients who underwent corneal transplantation with allografts contaminated Clostridium perfringens and to evaluate risk factors for anaerobic contamination in 2 donors.Patient records adverse reaction reports from a single eye bank related cases posttransplant C. endophthalmitis were reviewed. Records regarding mated corneas, donor autopsy reports, other pertinent data also reviewed.Three reactions associated reported. Two corneas. Both...
Purpose: To identify whether there has been a decline in ocular toxoplasmosis at tertiary uveitis practice.Methods: Retrospective review of new patients the University Illinois Uveitis Service from 1973 to 2012.Results: There were 6820 with adequate records for inclusion; 323 (4.7%) diagnosed toxoplasmosis. was 78.0% prevalence 2008 2012 compared 1977. Compared aggregate population, more likely be Hispanic (p<0.0001) and less African American (p<0.0001). Ocular Hispanics commonly occurred...
Purpose: To compare the variation in corneal endothelial cell density (ECD) from center to periphery unpeeled and peeled donor corneas determine impact of eccentric trephining on total cells Descemet membrane keratoplasty (DMEK) grafts. Methods: Mated cornea pairs were obtained. One each pair was for DMEK, whereas other left unpeeled. Alizarin Red used stain cells. High-resolution images at fixed magnification obtained center, midperiphery (2.5 mm center), (5 center). The then counted, ECD...
A 4-year-old girl with a history of Pearson marrow-pancreas syndrome presenting severe, progressive photophobia was found to have bilateral, diffuse corneal thickening and peripheral pigmentary retinopathy. She underwent Descemet stripping automated endothelial keratoplasty (DSAEK) surgery in both eyes using modified suture pull-through technique. Postoperatively there no evidence cataract formation or graft detachment; her corneas thinned, improved dramatically.