A5040012120- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Detection and Scintillator Technologies
- Boron Compounds in Chemistry
- Radiation Effects in Electronics
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Radiation Dose and Imaging
- Effects of Radiation Exposure
- Advanced X-ray and CT Imaging
- Radiomics and Machine Learning in Medical Imaging
- Atomic and Subatomic Physics Research
- DNA Repair Mechanisms
- Nuclear Physics and Applications
- Particle accelerators and beam dynamics
- Management of metastatic bone disease
- PARP inhibition in cancer therapy
- Particle Accelerators and Free-Electron Lasers
- Head and Neck Cancer Studies
- Advanced MRI Techniques and Applications
- Radiation Effects and Dosimetry
- Meningioma and schwannoma management
- Graphite, nuclear technology, radiation studies
- Superconducting Materials and Applications
- Neuroblastoma Research and Treatments
Mayo Clinic in Florida
2019-2025
WinnMed
2016-2025
Mayo Clinic
2014-2024
Osaka University
2023-2024
Case Western Reserve University
2024
Jacksonville College
2020-2024
University of Wollongong
2020-2021
Mayo Clinic in Arizona
2013-2020
Mayo Clinic Hospital
2015
St. Jude Children's Research Hospital
2007-2012
Purpose: Very fast Monte Carlo (MC) simulations of proton transport have been implemented recently on GPUs. However, these usually use simplified models for non-elastic (NE) proton-nucleus interactions. Our primary goal is to build a GPU-based MC with detailed modeling elastic and NE collisions. Methods: Using CUDA, we GPU kernels tasks: (1) Simulation spots from our scanning nozzle configurations, (2) Proton propagation through CT geometry, considering nuclear scattering, multiple energy...
Organ-at-risk segmentation for head and neck cancer radiation therapy is a complex time-consuming process (requiring up to 42 individual structure, may delay start of treatment or even limit access function-preserving care. Feasibility using deep learning (DL) based autosegmentation model reduce contouring time without compromising contour accuracy assessed through blinded randomized trial oncologists (ROs) retrospective, de-identified patient data.
This work aims to characterize a proton pencil beam scanning (PBS) and passive double scattering (DS) systems as well measure parameters relevant the relative biological effectiveness (RBE) of using silicon on insulator (SOI) microdosimeter with well-defined 3D sensitive volumes (SV). The dose equivalent downstream laterally outside clinical PBS treatment field was assessed compared that DS beam.A novel SVs used in this study. It connected low noise electronics, allowing for detection lineal...
Abstract Proton Bragg peak irradiation has a higher ionizing density than conventional photon or the entrance of proton beam profile. Whether targeting DNA damage response (DDR) could enhance vulnerability to distinct pattern induced by is currently unknown. Here, we performed genetic pharmacologic manipulation key DDR elements and evaluated signaling, repair, tumor control in cell lines xenografts treated with same physical dose across radiotherapy linear energy transfer spectrum....
Abstract Objective . To develop a new model (Mayo Clinic Florida microdosimetric kinetic model, MCF MKM) capable of accurately describing the in vitro clonogenic survival at low and high linear energy transfer (LET) using single-event spectra single target. Methodology The MKM is based on ‘post-processing average’ implementation non-Poisson includes novel expression to compute particle-specific quadratic-dependence cell with respect dose ( β linear-quadratic model). A methodology priori...
Purpose: Conventional spot scanning intensity modulated proton therapy (IMPT) treatment planning systems (TPSs) optimize weights based on analytical dose calculations. These calculations have been shown to severe limitations in heterogeneous materials. Monte Carlo (MC) methods do not these limitations; however, MC‐based of limited clinical use due the large number beam spots IMPT and extremely long calculation time traditional MC techniques. In this work, authors present a clinically...
To develop a clinical infrastructure that allows for routine Monte Carlo dose calculation verification of spot scanning proton treatment plans and includes simple biological model to aid in normal tissue protection.A graphical processing unit accelerated engine was used as the on plans. An built around this seamless exporting from planning system importing distribution via DICOM (digital imaging communications medicine). easy-to-use Web-based interface developed so application could be run...
The purpose of this work was to develop an end-to-end patient-specific quality assurance (QA) technique for spot-scanned proton therapy that is more sensitive and efficient than traditional approaches. methodology relies on independently verifying the accuracy delivered fluence dose calculation in heterogeneous patient volume. A Monte Carlo engine, which developed in-house, recalculates a planned distribution CT data set verify represented by treatment planning system. plan then...
Radiochromic film (RCF) is a valuable dosimetric tool, primarily due to its sub-millimeter spatial resolution. For accurate proton dosimetry, the dependence of response on linear energy transfer (LET) must be characterized and calibrated. In this work, we under-response, or 'quenching', as function dose-weighted (LETd) in several fields established simple, relationship with LETd.
The analytical microdosimetric function (AMF) implemented in the Monte Carlo code PHITS is a unique tool that bridges gap between macro- and microscopic scales of radiation interactions, enabling accurate calculations over macroscopic bodies. original AMF was published 2006, based on results track structure calculations. Recently, newer version proposed, incorporating an improved description energy loss at scale. This study compares older AMFs computing probability distributions, mean...
Abstract Background Locoregional failure is a significant concern in patients with high‐risk abdominal neuroblastoma (NB) receiving radiotherapy. control outcomes were studied children NB intensity modulated radiotherapy (IMRT). Procedure Twenty (11 females, 9 males) (median age at diagnosis 3.4 years) IMRT analyzed for locoregional failure, outcomes, and toxicities. doses 23.4 Gy (n = 12), 30 1), 30.6 5), 36.0 2) based on extent of resection. Five had tumors MYCN amplification, 19...
Relative biological effectiveness (RBE) accounts for the differences in effect from different radiation types. The RBE proton therapy remains uncertain, as it has been shown to vary clinically used value of 1.1. In this work we investigated protons and correlated with underlying physical quantities.Three cell lines were irradiated (CHO, Chinese hamster ovary; A549, human lung adenocarcinoma; T98, glioma) assessed survival by using clonogenic assay. Cells 71- 160-MeV at depths along Bragg...
Objective. To investigate similarities and differences in the formalism, processing, results of relative biological effectiveness (RBE) calculations with a weighting function (BWF), microdosimetric kinetic model (MKM) subsequent modifications (non-Poisson MKM, modified MKM). This includes: (a) extension V79-RBE10%BWF to RBE for other clonogenic survival levels; (b) novel implementation MKMs as functions; (c) benchmark against Chinese Hamster lung fibroblast (V79)in vitrodata; (d) study on...
Surgical treatment of pelvic sarcoma involving the bone is standard care but associated with several sequelae and reduced functional quality life (QOL). Treatment photon proton radiotherapy relapse. Carbon ion (CIRT) may reduce both relapse rates sequelae. The PROSPER study a tricontinental, nonrandomized, prospective, three-arm, pragmatic trial evaluating treatments bone. Patients aged at least 15 years are eligible for inclusion. Participants must have an Eastern Cooperative Oncology Group...