A5044835837- Cardiac Fibrosis and Remodeling
- Body Contouring and Surgery
- Reconstructive Surgery and Microvascular Techniques
- Tissue Engineering and Regenerative Medicine
- Pulmonary Hypertension Research and Treatments
- Cardiac Structural Anomalies and Repair
- Skin Diseases and Diabetes
- Cultural Insights and Digital Impacts
- Mesenchymal stem cell research
- Dermatological and COVID-19 studies
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Vascular Malformations and Hemangiomas
- Facial Rejuvenation and Surgery Techniques
- Tumors and Oncological Cases
- Adipose Tissue and Metabolism
- Congenital limb and hand anomalies
- ATP Synthase and ATPases Research
- Historical Studies and Socio-cultural Analysis
- Handwritten Text Recognition Techniques
- Digital Imaging in Medicine
- Skin and Cellular Biology Research
- Vitamin K Research Studies
- Infections and bacterial resistance
- Breast Implant and Reconstruction
Institut de Radioprotection et de Sûreté Nucléaire
2024
Université Paris Cité
2007-2023
Inserm
2007-2023
Sorbonne Université
2007-2023
Assistance Publique – Hôpitaux de Paris
2007-2023
Paris Cardiovascular Research Center
2019-2022
Unité de recherche sur les maladies cardiovasculaires et métaboliques
2017-2018
Université Sorbonne Paris Nord
2017
Fondation pour l’innovation en Cadiométabolisme et Nutrition
2017
Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers
2013
Abstract There is currently no therapy to limit the development of cardiac fibrosis and consequent heart failure. We have recently shown that post-myocardial infarction (MI) can be regulated by resident cells with a fibrogenic signature identified expression PW1 ( Peg3 ). Here we identify αV-integrin (CD51) as an essential regulator + behavior. used transcriptomic proteomic approaches specific cell-surface markers for found was expressed in almost all (93% ± 1%), predominantly αVβ1 complex....
Pulmonary veno-occlusive disease (PVOD) occurs in humans either as a heritable form (hPVOD) due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2) or sporadic older age (sPVOD). The chemotherapeutic agent mitomycin C (MMC) is potent inducer PVOD and rats (MMC-PVOD). Here, we compared human hPVOD sPVOD, MMC-PVOD pathophysiology at the histological, cellular, molecular levels unravel common altered pathomechanisms. MMC exposure was associated primarily with arterial microvessel...
Myocardial infarction (MI) induces a repair response that ultimately generates stable fibrotic scar. Although the scar prevents cardiac rupture, an excessive profibrotic impairs optimal recovery by promoting development of noncontractile areas. The mechanisms lead to fibrosis are diverse and incompletely characterized. We explored whether expansion fibroblasts after MI can be regulated through paracrine action stromal cells.We performed bioinformatic secretome analysis PW1+ cells isolated...
Background Treatment options for congenital hypoplastic breast anomalies are often open, including radial scoring, parenchymal flaps, and insertion of expanders implants. Drawbacks open techniques involve scarring, the use drains, inpatient stays. The lipofilling to treat deformities is increasing, as more research completed in this area. Patients Methods We report a retrospective study 10 patients below age 20 following autologous fat transfer between January 1, 2003 2004. (2 Poland...
This prospective study explored effectiveness and safety of Macrolane VRF30 for treatment buttock lipoatrophy in HIV-infected subjects. Ten subjects who were unable to sit more than 30 minutes because pain injected with a mean 276 mL followed 18 months. The score was reduced, the time that could increased at least up 9 months post treatment. There no local displacement gel. Five mild adverse events occurred; all related injection procedure. pilot indicates is promising, well-tolerated method...
According to our previous study suggesting that antioxidant properties of phytochemicals in the diet decrease glioma aggressiveness, we used a SUVIMAX-like (“Supplementation en VItamines et Minéraux AntioXydants”) (enriched with alpha-tocopherol, beta carotene, vitamin C, zinc, and sodium selenite), adapted rats. The present results showed each antioxidants inhibited growth cells vitro. When combination for vivo studies, highly significant delay clinical signs disease, but not statistical...
Microsurgery is the procedure of choice for vascular anastamoses between 0.5 and 0.8 mm in diameter. The objective this study was to compare two types suture materials: non-absorbable, commonly used microsurgery, vs absorbable, rarely evaluated type surgery. Twenty albino Wistar rats (average weight: 220 g) were operated on under surgical microscope with an enlargement from X3.2 X20, perform a transvers section both femoral arteries immediately followed by anastamosis. interventions...
Hereditary pulmonary veno-occlusive disease (hPVOD) is a severe form of autosomal recessive hypertension and due to biallelic loss function the EIF2AK4 gene (alias GCN2) coding for GCN2. GCN2 stress kinase that belongs integrated response pathway (ISR). Three rat lines carrying Gcn2 mutation were generated found phenotypically normal did not spontaneously develop PVOD-related disease. We submitted these rats amino acid deprivation document molecular cellular lungs identify phenotypic changes...