A5051980102- BRCA gene mutations in cancer
- Advanced Breast Cancer Therapies
- DNA Repair Mechanisms
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- PI3K/AKT/mTOR signaling in cancer
- Nutrition, Genetics, and Disease
- PARP inhibition in cancer therapy
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- Chronic Lymphocytic Leukemia Research
Ministry of Health of the Russian Federation
2022-2024
Krasnoyarsk Regional Clinical Hospital
2023
Regional Cancer Center
2023
Oncological Dispensary No. 2
2022
Background. By 2020, breast cancer (BC) has become the most frequent malignancy in world. The common type of BC is HR+/HER2-negative cancer,2540% which harbors PIK3CA mutations that affect catalytic subunit PI3K protein. alterations are actionable, as such neoplasms can be treated with a combination fulvestrant and inhibitor alpelisib. As have an extremely versatile effect on characteristics tumor cell, numerous associations various clinico-pathological traced.
 Aim. Our aim was to...
Background . Data on the prognostic role of PIK3CA mutation in hormone receptor-positive (HR+) HER2-negative (HER2–) breast cancer (BC) are contradictory; nevertheless, there indications its negative predictive and significance. This dictates need for early genetic testing BC to predict clinical course, select a primary therapy option individualize systemic treatment with disease progression. Investigation regulation tumor cell cycle, as well relationship between markers, infiltration...
PARP inhibitors. However, in clinical practice, despite the proven antitumor efficacy of drugs, acquired resistance to inhibitors leads difficulties selecting further therapy due unknown mechanisms and absence algorithm action. Despite various inhibitors, choice subsequent combination after detection should be based on an understanding these existence heterogeneous metastatic process. At same time, it is very important study molecular genetic characteristics disease at each stage...
Background . It is suggested that defects in BRCA1 / 2 genes contribute to a high mutational load and immunogenicity, which modulates immune microenvironment. At the same time, it was shown -associated breast cancer tumors do not belong category of immunoactive ones. These have low expression response exhibit an immunosuppressive type This indicates need antitumor modulation maintaining optimal balance tumor CD4/CD8 T-lymphocytes ratio. In addition, there evidence additional evaluation TP53...
Abstract Background Mountain areas of the North Caucasus host several large ethnic communities that preserved their national identity over centuries. Methods This study involved high-grade serous ovarian cancer (HGSOC) and breast (BC) patients from Dagestan (HGSOC: 37; BC: 198), Kabardino-Balkaria 68; 155), Ossetia 51; 104), Chechnya 79), Ingushetia 19; 103), Karachay-Cherkessia 13; 47), Armenian settlements 16; 101). The group BC was enriched by young-onset and/or family history-positive...
Introduction . Patients with hormone-receptor-positive (HR+) breast cancer (BC) over 40 years old who take tamoxifen are not subject to mandatory castration. However this cohort of patients is homogeneous. Aim The present study aimed at studying the features ovarian steroidogenesis in perimenopausal receiving adjuvant hormone therapy (HT) tamoxifen. Materialy and methods included 82 aged 42 53 GH+BC received HT 20 mg daily. Within 9 months from start patients, levels estradiol...
Background . Currently, there is growth evidence on prognostic and clinical differences in breast cancer (BC) associated with different types of BRCA1 / 2 mutations. At the same time, a triple negative tumor phenotype not an absolute pathognomonic sign -associated cancer, where luminal phenotypes are being detected increasingly. In addition, attention paid to significance estrogen signaling mechanism depending surrogate type, including due alternative mechanisms. Objective : evaluate 2-...
Current clinical recommendations indicate the need for a biopsy of metastatic focus in breast cancer (BC), but optimal frequency additional molecular analysis remains unclear. The discordance hormonal receptors (HR) between primary tumor and foci has prognostic significance, while transition from HR-positive BC to triple negative phenotype is associated with worse prognosis. Acquisition HR expression more favorable due wide range options treatment. Over past few years, PARP inhibitors have...