A5013139113- Trypanosoma species research and implications
- Insect symbiosis and bacterial influences
- CRISPR and Genetic Engineering
- Developmental Biology and Gene Regulation
- Neurobiology and Insect Physiology Research
- Viral Infections and Outbreaks Research
- Marine and coastal plant biology
- Insect and Pesticide Research
- Animal Genetics and Reproduction
- Soil Management and Crop Yield
- Mosquito-borne diseases and control
- Insect and Arachnid Ecology and Behavior
- Venomous Animal Envenomation and Studies
- Rural Development and Agriculture
Universidade Federal do Rio de Janeiro
2020-2024
University of California, San Diego
2023
is currently the model vector of choice for studying Chagas disease transmission, a debilitating caused by
Pigmentation in insects has been linked to mate selection and predator evasion, thus representing an important aspect for natural selection. Insect body color is classically associated the activity of tyrosine pathway enzymes, eye pigment synthesis through tryptophan guanine pathways, their transport by ATP-binding cassette proteins. Among hemiptera, genetic basis pigmentation kissing bugs such as Rhodnius prolixus, that transmit Chagas disease humans, not addressed. Here, we report...
Development of effective therapies against SARS-CoV-2 infections relies on mechanistic knowledge virus-host interface. Abundant physical interactions between viral and host proteins have been identified, but few functionally characterized. Harnessing the power fly genetics, we develop a comprehensive Drosophila COVID-19 resource (DCR) consisting publicly available strains for conditional tissue-specific expression all encoded proteins, UAS-human cDNA transgenic lines encoding established...
Dorsal–ventral (DV) patterning is regulated by the bone morphogenetic pathway (BMP) in Bilateria. In insect DV patterning, Toll also plays a role, addition to BMPs. Variations relative importance of each for have been reported using single species coleopteran, hymenopteran, hemipteran and orthopteran insects. To investigate if molecular control conserved inside an order, emergent model hemiptera Rhodnius prolixus was studied. We found that R. BMP controls entire axis, with broader effect...
Abstract The kissing bug Rhodnius prolixus is a major vector for Chagas disease in the Americas, and also considered as primary model functional studies. Prospective transgenic approaches genome editing strategies hold great promise controlling insect populations well propagation. In this context, identifying visible genetic markers methodologies of paramount importance to advance field. Here we have identified analyzed function putative cuticle eye color genes by investigating effect gene...
Abstract Rhodnius prolixus is currently the model vector of choice for studying Chagas disease transmission, a debilitating caused by Trypanosoma cruzi parasites. Despite broad use double-stranded RNA interference knockdown gene function in R. , transgenesis and editing protocols are still lacking. Here we tested Receptor-Mediated Ovary Transduction Cargo (ReMOT Control) direct parental injection CRISPR (DIPA-CRISPR) maternal delivery CRISPR/Cas9 elements to developing oocytes, strategies...