A5033445139- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Long-Term Effects of COVID-19
- COVID-19 Clinical Research Studies
- Cardiomyopathy and Myosin Studies
- Nosocomial Infections in ICU
- Intensive Care Unit Cognitive Disorders
- Chronic Disease Management Strategies
- Cardiac Arrest and Resuscitation
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- Respiratory Support and Mechanisms
- Immune Response and Inflammation
- Trauma and Emergency Care Studies
- Asthma and respiratory diseases
- Liver Disease Diagnosis and Treatment
- Innovation Policy and R&D
- Clinical Reasoning and Diagnostic Skills
- Dermatological and COVID-19 studies
- Diabetic Foot Ulcer Assessment and Management
- Spinal Cord Injury Research
- COVID-19 and healthcare impacts
- Advanced Biosensing Techniques and Applications
- Central Venous Catheters and Hemodialysis
- Aortic aneurysm repair treatments
Columbia University Irving Medical Center
2024-2025
The University of Tokyo
2021-2025
University of Tokyo Hospital
2019-2024
Tokyo Medical and Dental University
2024
Polymyxin B hemadsorption (PMX-HA) reduces blood endotoxin levels, but characteristics of patients with sepsis likely to benefit from PMX-HA are not well known. We sought identify patient subgroups PMX-HA.We retrospectively identified 1911 a retrospective observational study in Japan (the JSEPTIC-DIC study) and 286 endotoxemic septic shock randomized controlled trial North America that restricted those high activity EUPHRATES trial). applied the machine learning-based causal forest model...
Abstract High-need, high-cost (HNHC) patients—usually defined as those who account for the top 5% of annual healthcare costs—use much half total costs. Accurately predicting future HNHC patients and designing targeted interventions them has potential to effectively control rapidly growing expenditures. To achieve this goal, we used a nationally representative random sample working-age population underwent screening program in Japan 2013–2016, developed five machine-learning-based prediction...
Objectives There have been concerns that patients with chronic conditions may be avoiding in-person physician visits due to fear of COVID-19, leading lower quality care. We aimed investigate changes in and medication prescriptions for diseases before during the COVID-19 pandemic at population level. Design Retrospective cohort study. Setting Nationwide claims data Japan, 2018–2020. Participants Working-age (aged 18–74 years) who visited physicians received any major (hypertension, diabetes...
BACKGROUND: Hypertrophic cardiomyopathy is the most common genetic and causes major adverse cardiovascular events (MACE). SVEP1 (Sushi, von Willebrand factor type A, epidermal growth factor, pentraxin domain containing 1) a large extracellular matrix protein that detectable in plasma. However, it unknown whether adding plasma levels to clinical predictors including NT-proBNP (N-terminal pro-B-type natriuretic peptide) improves prognostication patients with hypertrophic cardiomyopathy....
Abstract The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management Sepsis and Septic Shock (J‐SSCG 2024) is published by Society Intensive Care Medicine Association Acute Medicine. This fourth revision since first was in 2012. purpose guidelines to assist healthcare providers making appropriate decisions treatment sepsis septic shock, leading improved patient outcomes. We aimed create that are easy understand use physicians who recognize provide initial management,...
Abstract Background Tranexamic acid reduces bleeding deaths in trauma patients, but the treatment benefit depends on time from injury. It is recommended that tranexamic be administered immediately and only within 3 h of injury; however, optimal criteria have not been adequately studied. Methods We applied machine learning–based causal forest models to investigate heterogeneity effects 24-hour mortality rate conditional covariates (for example age, sex, injury, systolic blood pressure,...
Abstract In 2008, Oregon expanded its Medicaid program using a lottery, creating rare opportunity to study the effects of coverage randomized controlled design (Oregon Health Insurance Experiment). Analysis showed that lowered risk depression. However, this effect may vary between individuals, and identification individuals likely benefit most has potential improve effectiveness efficiency program. By applying machine learning causal forest data from experiment, we found substantial...
To investigate determining factors of happiness during the COVID-19 pandemic. Observational study. Large online surveys in Japan before and A random sample 25 482 individuals who are representatives Japanese population. Self-reported measured using a 10-point Likert scale, where higher scores indicated levels happiness. We defined participants with ≥8 on scale as having high Among respondents, median score self-reported was 7 (IQR 6-8), 11 418 (45%) reporting The multivariable logistic...
The quick sequential organ failure assessment (qSOFA) was widely used to estimate the risks of sepsis in patients with suspected infection prehospital and emergency department (ED) settings. Due insufficient sensitivity qSOFA on arrival at ED (ED qSOFA), Surviving Sepsis Campaign 2021 recommended against using as a single screening tool for sepsis. However, it remains unclear whether combined use improves its identifying higher risk ED.We retrospectively analyzed data from tertiary medical...
The Surviving Sepsis Campaign Guidelines 2021 recommends that adult patients with sepsis requiring intensive care should be admitted to the ICU within 6 hours of their emergency department (ED) visits. However, there is limited evidence on whether best target time for compliance bundle. We aimed investigate association between from ED visits admission (i.e., length stay [ED-LOS]) and mortality identify optimal ED-LOS sepsis.Retrospective cohort study.The Medical Information Mart Intensive...
Frequent emergency department (ED) users increase the burden on EDs. However, little is known about characteristics and subgroups of frequent ED in Japan.We retrospectively analyzed data patients who had visited an academic hospital Japan between 2014 2015. We identified adult (four or more visits within 365 days prior to one's last visit) sampled non-frequent users. compared these groups delineate examined association use hospitalization rates. Additionally, identify latent users, we...
Patients with acute bronchospasm can show a distinct slope of the capnogram ("shark fin") as result asynchronous alveolar excretion. Although upward plateau (phase III) in waveforms non-intubated patients is known to help monitor therapeutic response bronchospasm, little about significance its among intubated patients. Therefore, we quantified phase III an patient asthma investigate whether could be useful for identifying antibronchospasm treatment real time.The was 53-year-old man who had...
To evaluate the contribution of a preextubation chest X-ray (CXR) to identify risk extubation failure in mechanically ventilated patients.Retrospective cohort study.ICUs tertiary center (the Medical Information Mart for Intensive Care IV database).Patients greater than or equal 18 years old who were and extubated after spontaneous breathing trial.None.Among 1,066 patients, 132 patients (12%) experienced failure, defined as reintubation death within 48 hours extubation. predict we developed...
<title>Abstract</title> Remdesivir, approved for clinical use against COVID-19 worldwide, has varying effectiveness, depending on the respiratory failure status of patients. This retrospective observational study (the J- RECOVER) aimed to evaluate variations in remdesivir effectiveness by enrolling patients with from 64 institutions Japan between January 1 and September 30, 2020. included aged ≥ 18 years who were administered within three days admission. A total 3,591 eligible, propensity...
Background: Alcohol septal ablation (ASA) and myectomy (SM) are 2 options for reduction therapy (SRT) to treat medication-resistant symptomatic obstructive hypertrophic cardiomyopathy (HCM). Because differences in mortality rates after these different SRT methods have not been extensively investigated real-world settings, this study compared the 1-year ASA SM using population-based database.
Abstract Background Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease with a prevalence between 1 in 200 to 500 [1]. HCM can lead major adverse cardiovascular events (MACE) such as failure (HF) hospitalization and cardiac death [2,3]. A protein named "sushi, von Willebrand factor type A, EGF pentraxin domain containing 1" (SVEP1) large extracellular matrix whose activity be measured plasma [4,5]. SVEP1 promotes inflammation atherosclerosis associated risk of HF...