A5069580679- Genetics, Aging, and Longevity in Model Organisms
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Amino Acid Enzymes and Metabolism
- MicroRNA in disease regulation
- Telomeres, Telomerase, and Senescence
- Genetic Associations and Epidemiology
- Nutrition and Health in Aging
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- DNA Repair Mechanisms
- Frailty in Older Adults
- Diet, Metabolism, and Disease
- Cell Adhesion Molecules Research
- Bioinformatics and Genomic Networks
- Selenium in Biological Systems
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Biochemical effects in animals
- Adipokines, Inflammation, and Metabolic Diseases
- Alzheimer's disease research and treatments
- RNA and protein synthesis mechanisms
- Erythropoietin and Anemia Treatment
University of Calabria
2015-2024
Sarcopenia and malnutrition are commonly occurring conditions in the elderly that frequently coexist, leading to substantial effects on morbidity/mortality. Evidence established muscle-specific microRNAs (miRNAs) or myomiRs as essential regulators of skeletal muscle processes, from myogenesis homeostasis. This study aimed evaluate association between sarcopenia explore potential nutrition mediating this association. qPCR was employed characterize myomiR-1, -133a/b, -206, -208b, -499...
In humans Uncoupling Proteins (UCPs) are a group of five mitochondrial inner membrane transporters with variable tissue expression, which seem to function as regulators energy homeostasis and antioxidants. particular, these proteins uncouple respiration from ATP production, allowing stored be released heat. Data experimental models have previously suggested that UCPs may play an important role on aging rate lifespan. We analyzed the genetic variability human in cohorts subjects ranging...
Several studies have shown that genetic factors account for 25% of the variation in human life span. On basis published molecular, and epidemiological data, we hypothesized polymorphisms taste receptors, which modulate food preferences but are also expressed a number organs regulate absorption processing metabolism, could aging process. Using tagging approach, investigated possible associations between longevity common at three bitter receptor gene clusters on chromosomes 5, 7 12 population...
Type 2 Diabetes (T2D) is a chronic disease associated with number of micro- and macrovascular complications that increase the morbidity mortality patients. The risk diabetic has strong genetic component. To this end, we sought to evaluate association 40 single nucleotide polymorphisms (SNPs) in 21 candidate genes T2D its vascular 503 patients 580 healthy controls. were chosen because previously reported be and/or aging process. We replicated IGF2BP rs4402960 detected novel associations TERT...
Many studies have suggested that individual differences in aging phenotypes may be associated to polymorphisms affecting gene regulation. As single-nucleotide (SNPs) the 3′-untranslated regions (3′UTR) targeted by microRNAs (miRNAs) can alter strength of miRNA binding (and, consequently, regulation target genes), we wondered whether these SNPs (known as miRSNPs) affect chance become long-lived. Thus, estimated effect miRSNPs falling 140 aging-related genes on DNA/miRNA bond. The 24 with...
Tissue specific somatic mutations occurring in the mtDNA control region have been proposed to provide a survival advantage. Data on twins and relatives of long-lived subjects suggested that occurrence/accumulation these may be genetically influenced. To further investigate heteroplasmy elderly, we analyzed segment surrounding nt 150 position (previously reported as Leukocytes) various types leukocytes obtained from 195 ultra-nonagenarians sib-pairs Italian or Finnish origin collected frame...
Xenobiotic-metabolizing enzymes (XME) mediate the body’s response to potentially harmful compounds of exogenous/endogenous origin which individuals are exposed during their lifetime. Aging adversely affects such responses, making elderly more susceptible toxics. Of note, XME genetic variability was found impact ability cope with xenobiotics and, consequently, disease predisposition. We hypothesized that these genes influencing interaction exposome could affect individual chance becoming...
Human TP53 gene is characterised by a polymorphism at codon 72 leading to an Arginine-to-Proline (R/P) substitution. The two resulting p53 isoforms have different subcellular localisation after stress (more nuclear or more mitochondrial for the P R isoform, respectively). p53P72 variant efficient than p53R72 in inducing expression of genes involved DNA repair. Since also (mtDNA) maintenance, we wondered whether these are associated with accumulation mtDNA damage. We observed that cells...
Abstract Advanced age is the largest risk factor for late‐onset Alzheimer's disease (LOAD), a in which susceptibility correlates to almost all hallmarks of aging. Shared genetic signatures between LOAD and longevity were frequently hypothesized, likely characterized by distinctive epistatic pleiotropic interactions. Here, we applied multidimensional reduction approach detect gene–gene interactions affecting large dataset genomic variants harbored genes insulin/IGF1 signaling, DNA repair,...
Telomeres are structures at the ends of eukaryotic chromosomes that help maintain genomic stability. During aging, telomere length gradually shortens, producing short telomeres, which markers premature cellular senescence. This may contribute to age-related diseases, including Alzheimer's disease (AD), and based on this, several studies have hypothesized shortening characterize AD. Current research, however, has been inconclusive regarding direction association between leukocyte (LTL) risk....
Uncoupling proteins (UCPs) are a group of five mitochondrial inner membrane transporters with tissue specific expression that uncouple biofuel oxidation from ATP synthesis and function as regulators energy homeostasis antioxidants. Previous data suggested neuronal UCPs (UCP2, UCP4, an d UCP5) can directly influence synaptic plasticity, neurotransmission, neurodegenerative processes, have crucial role in the protection central nervous system. In fact, it has been observed significantly...
The study of the genetics longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. "price pay" is population-specific evolutionary histories and trade-offs were neglected in investigation gene-environment interactions. We propose a new "diachronic" approach considers processes occurred at both lifespan timescales. focused on well-characterized population terms history (i.e. Italians) we generated genome-wide data for...
Oxidative stress is a major determinant of human aging and common hallmark age-related diseases. A protective role against free radicals accumulation was shown for thioredoxin reductase TrxR1, key antioxidant selenoprotein. The variability encoding gene ( TXNRD1 ) previously found associated with physical status at old age extreme survival in Danish cohort. To further investigate the influence on physiological decline, we analyzed 9 tagging SNPs relation to markers (Activity Daily Living,...
Abstract Type-2 Diabetes (T2D), diabetic complications, and their clinical risk factors harbor a substantial genetic component but the contributing to overall diabetes mortality remain unknown. Here, we examined association between variants at 21 T2D-susceptibility loci all-cause in an elderly cohort of 542 Italian patients who were followed for average 12.08 years. Univariate Cox regression analyses detected age, waist-to-hip ratio (WHR), glycosylated haemoglobin (HbA1c), duration,...
Telomeres are subject to age related shortening which can be accelerated by oxidative stress and inflammation. Many studies have reported an inverse correlation between telomere length survival, but such has not been always confirmed in different populations. We analyzed the trend of Leukocyte Telomere Length (LTL) as a function cohort 516 subjects aged 65-106 years from Southern Italy. The LTL obtained was quite similar demographic survival curves with data western societies. observed...