A5101704368- Formal Methods in Verification
- Complexity and Algorithms in Graphs
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- RNA Interference and Gene Delivery
- Logic, Reasoning, and Knowledge
- Ion channel regulation and function
- Advanced Graph Theory Research
- Endoplasmic Reticulum Stress and Disease
- Protein Kinase Regulation and GTPase Signaling
- Ion Channels and Receptors
- Plasma Diagnostics and Applications
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Sirtuins and Resveratrol in Medicine
- Advanced Glycation End Products research
- Vibration Control and Rheological Fluids
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Constraint Satisfaction and Optimization
- Dynamics and Control of Mechanical Systems
- Cellular transport and secretion
- Epigenetics and DNA Methylation
- Metal and Thin Film Mechanics
Osaka Metropolitan University
2025
National Center for Geriatrics and Gerontology
2024
Japan Tobacco (Japan)
2024
Kyoto University Institute for Chemical Research
2019-2023
Kyoto University
2014-2023
Kyoto Bunkyo University
2019-2023
Yamagata University
2023
Waseda University
2019-2022
Gifu Pharmaceutical University
2016-2021
Kobe University
2021
The Trp gene product has been proposed as a candidate protein for the store-operated Ca 2+ channel, but protein(s) not identified in any nonexcitable cell. We report here cloning of rat brain Trp1β cDNA and detection immunolocalization endogenous expressed Trp1 protein. A 400-bp product, with >95% homology to mouse Trp1, was amplified from submandibular gland RNA. Rat-specific primers were used full-length (rTrp1), encoding 759 amino acids. Northern blot analysis demonstrated transcript...
This study examines the methods for approximating fast attitude maneuver of a spacecraft with flexible structures. Two have been proposed maneuvering around single axis, in which torque input is provided form time polynomial. In Method 1, residual first-order vibration mode was eliminated by appropriately selecting time. 2, suppressed adding boundary conditions mode, and could be freely set. Furthermore, this demonstrates that both are effective reducing higher-order modes. We also...
Midkine and pleiotrophin form a family of growth factors. Mice deficient in one the genes show few abnormalities on reproduction development. To understand their roles these processes, we produced mice both genes; double were born only third number expected by Mendelian segregation 4 weeks after birth weighed about half as much wild‐type mice. Most female infertile. In mice, numbers mature follicles ova at ovulation reduced compared to Both midkine expressed follicular epithelium granulosa...
Abstract Heat shock protein 47 (HSP47) is an endoplasmic reticulum (ER)-resident molecular chaperone that specifically recognizes triple helical portions of procollagens. The function HSP47 indispensable in mammals, and hsp47 -null mice show embryonic lethal phenotype accompanied by severe abnormalities collagen-based tissue structures. Two leading hypotheses are currently accepted for the as a procollagen-specific chaperone. One facilitation procollagen folding stabilizing thermally...
In [3H]myristic acid-labelled osteoblast-like MC3T3-E1 cells, prostaglandin F2 alpha (PGF2 alpha)-induced PLD activity was assessed by measuring the [3H]phosphatidylethanol (PEt) formation in presence of ethanol. Inhibition increase intracellular Ca2+ concentration ([Ca2+]i) U73122, an inhibitor phosphoinositide-specific phospholipase C (PI-PLC), or chelation extracellular with EGTA BAPTA, suppressed PGF2 alpha-induced D (PLD) activation. Neither protein kinase (PKC) inhibitors nor PKC...
Purpose This study aims to improve the understanding of factors that influence performance universities' technology transfer offices (TTOs), units charged with responsibility for aiding commercialization research innovations. Design/methodology/approach To empirically test link between affecting TTO and whether these effects are contingent on a country-specific environment, survey data were collected from 187 stakeholders (TTO heads, employees university researchers) in 18 countries Europe...
A number of RORγ inhibitors have been reported over the past decade. There were also several examples advancing to human clinical trials, however, none them has reached market yet, suggesting that there could be common obstacles for their future development. As was expected from general homology nuclear receptor ligands, insufficient selectivity as well poor physicochemical properties identified potential risks a program. Based on such considerations, we conducted SAR investigation by...
Abstract Obesity is a major risk factor for colorectal cancer (CRC). Sustained hyperglycemia destabilizes tumor suppressor ten-eleven translocation (TET) 2, which substrate of AMPK, thereby dysregulating 5-hydroxymethylcytosine (5-hmC). However, the role played by this novel pathway in development obesity-related CRC unclear. In study, we aimed to evaluate expression levels TET2 and 5-hmC effects on proliferation cells. To end, surgically resected samples from seven obese patients (Ob-CRC)...
Spatiotemporal structural alterations in cellular membranes are the hallmark of many vital processes. In these events, induction local changes membrane curvature often plays a pivotal role. Many amphiphilic peptides able to modulate curvature, but there is little information on specific factors that direct change. Epsin-1 representative protein thought initiate invagination plasma upon clathrin-coated vesicles formation. Its N-terminal helical segment (EpN18) key role inducing positive...
Interferon-gamma (IFN-gamma) +/- tumor necrosis factor-alpha (TNF-alpha) induces antiproliferation and intracellular Ca2+ store depletion in a human submandibular ductal cell line (HSG), which can be reversed on cytokine removal [A. J. Wu, G. C. Chen, B. Baum, I. S. Ambudkar. Am. Physiol. 270 (Cell 39): C514-C521, 1996]. Here we have examined possible mechanism for the IFN-gamma-induced depletion. There was time-dependent decrease thapsigargin-dependent internal release after exposure of...
Abstract To develop antitumor drugs capable of targeting energy metabolism in the tumor microenvironment, we produced a series potent new biguanide derivatives via structural modification arylbiguanide scaffold. We then conducted biological screening using hypoxia inducible factor (HIF)-1- and unfolded protein response (UPR)-dependent reporter assays selective cytotoxicity assay under low glucose conditions. Homologation studies aryl-(CH 2 ) n -biguanides (n = 0–6) yielded highly with an...
The reaction between mass-separated low-energy (30 eV) SiCl n + ion beams and Si SiO 2 substrates was studied to investigate the influence of number Cl atoms in species on their deposition characteristics. It has been found that yield is positive (deposition) at =1 it becomes negative (etching) =3 substrate while nearly zero . In presence O gas, deposited change silicon oxides also takes place with 3 etching by , however, be unaffected These results can explained if adsorbed are assumed...
A Boolean function f:{0,1}^n -> {0,1} is weighted symmetric if there exist a g: Z and integers w_0, w_1, ..., w_n such that f(x_1, ...,x_n) = g(w_0+sum_{i=1}^n w_i x_i) holds. In this paper, we present algorithms for the circuit satisfiability problem of bounded depth circuits with AND, OR, NOT gates limited number gates. Our run in time super-polynomially faster than 2^n even when super-polynomial maximum weight nearly exponential. With an additional trick, give algorithm runs...
Lipid packing has a strong influence on the formation and structural dynamics of cell membranes. Techniques to modulate lipid may thus enable modification cellular functions events. An 18-residue amphiphilic helical peptide derived from N-terminal segment epsin-1 (EpN18) is reported induce positive membrane curvature loosen in membrane. In this study, it shown that EpN18, crosslinked leucine-zipper K4, recruited surface by interacting with cell-surface-expressed E3 segment. Cell-surface...