A5034146008- Neuroscience and Neuropharmacology Research
- Osteoarthritis Treatment and Mechanisms
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Neuroscience and Neural Engineering
- Inflammatory mediators and NSAID effects
- Polyamine Metabolism and Applications
- Total Knee Arthroplasty Outcomes
- Electromagnetic Fields and Biological Effects
- Cerebral Palsy and Movement Disorders
- NF-κB Signaling Pathways
- Mitochondrial Function and Pathology
- Lower Extremity Biomechanics and Pathologies
- Foot and Ankle Surgery
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Electrospun Nanofibers in Biomedical Applications
- Sports injuries and prevention
- Cardiac electrophysiology and arrhythmias
- Stress Responses and Cortisol
- Balance, Gait, and Falls Prevention
- Adipose Tissue and Metabolism
Istituto Ortopedico Rizzoli
2011-2025
University of Bologna
2010-2025
Azienda Ospedaliero-Universitaria di Modena
2024
Istituti di Ricovero e Cura a Carattere Scientifico
2024
Azienda Unità Sanitaria Locale Della Romagna
2023
Icahn School of Medicine at Mount Sinai
2013
Institut National de Recherche en Santé Publique
2013
Institute of Electronics, Computer and Telecommunication Engineering
2006
University of California, Los Angeles
1996-2000
University of Turin
1996
Abstract Introduction Recent evidence suggests that tissue accumulation of senescent p16 INK4a -positive cells during the life span would be deleterious for functions and could consequence inherent age-associated disorders. Osteoarthritis (OA) is characterized by chondrocytes expressing markers senescence-associated secretory phenotype (SASP), including matrix remodeling metalloproteases MMP1/MMP13 pro-inflammatory cytokines interleukin-8 (IL-8) IL-6. Here, we evaluated role in OA-induced...
Tedeschi, Roberto; Platano, Daniela; Donati, Danilo; Giorgi, Federica Author Information
This comprehensive study explores the various aspects of metacarpal fractures, a prevalent condition in hand injuries. We delve into anatomy metacarpals, elucidating how their structural characteristics influence fracture mechanics and treatment options. Special attention is given to diverse types particularly differing tolerances for angular, shortening, rotational deformities. The manuscript extensively reviews conservative approaches, emphasizing efficacy non-surgical methods like...
Several classes of voltage-gated Ca 2+ channels (VGCCs) are inhibited by G proteins activated receptors for neurotransmitters and neuromodulatory peptides. Evidence has accumulated to indicate that non-L-type the executing arm protein is its βγ dimer (Gβγ). We report below existence two Gβγ-binding sites on A-, B-, E-type α 1 subunits form channels. One, reported previously, in loop connecting transmembrane domains I II. The second located approximately middle ca. 600-aa-long C-terminal...
Background Healthcare-Associated Infections (HAIs) are one of the most frequent complications occurring in healthcare facilities. Contaminated environmental surfaces provide an important potential source for transmission many healthcare-associated pathogens, thus indicating need new and sustainable strategies. Aim This study aims to evaluate effect a novel cleaning procedure based on mechanism biocontrol, presence survival several microorganisms responsible HAIs (i.e. coliforms, Staphyloccus...
The management of pain and functional recovery following a radial capitellum fracture poses significant clinical challenge, especially in individuals whose professions, such as physiotherapy, demand optimal joint functionality. Transcranial Direct Current Stimulation (tDCS) emerges potential non-pharmacological intervention for management, necessitating exploration the context orthopedic injuries.
β subunits of voltage-gated Ca 2+ channels are encoded in four genes and display additional molecular diversity because alternative splicing. At the functional level, all forms very similar except for β2a, which differs that it does not support prepulse facilitation α 1C channels, inhibits voltage-induced inactivation neuronal 1E is more effective blocking inhibition by G protein-coupled receptors. We show distinguishing properties rather than interaction with a distinct site 1 , recently...
Abstract Background Impingement syndrome, a common cause of shoulder pain, often leads to functional limitations. Manual thoracic therapy is frequently employed as non-surgical intervention, but its efficacy remains debated. This review assesses the impact manual on pain reduction and improvement in impingement syndrome. Methods A systematic randomized clinical trials was conducted, focusing studies that applied patients with The primary outcomes were improvement. Studies evaluated for...
Background In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between anabolic and catabolic activity of chondrocytes and, thus, articular cartilage derangement. This study was aimed at providing further insight into impairment cytokine IL-4 its receptors in human OA cartilage, as well potential ability to antagonize phenotype induced by IL-1β. Methodology/Principal Findings The vivo expression receptor subunits (IL-4R, IL-2Rγ, IL-13Rα1) investigated on full...
To link matrix metalloproteinase 13 (MMP-13) activity and extracellular (ECM) remodeling to alterations in regulatory factors leading a disruption chondrocyte homeostasis.MMP-13 expression was ablated primary human chondrocytes by stable retrotransduction of short hairpin RNA. The effects MMP-13 knockdown on key regulators differentiation (SOX9, runt-related transcription factor 2 [RUNX-2], beta-catenin) angiogenesis (vascular endothelial growth [VEGF]) were scored at the protein level (by...
The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti- inflammatory responses, cellular survival and differentiation. Here, we have investigated the mechanism of action IKKα as a novel effector human murine chondrocyte extracellular matrix (ECM) homeostasis differentiation towards hypertrophy.IKKα expression was ablated in primary osteoarthritic (OA) chondrocytes immature articular (iMACs)...
: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as tremors, rigidity, and bradykinesia. Rehabilitation utilizing mirror neurons leverages the brain's capacity for action observation (AO) imagery (MI) to enhance function. This approach involves patients imitating movements observed in therapists or videos, aiming improve gait, coordination, overall quality of life. Mirror neuron activation facilitates learning may decelerate progression, thus...
Single-limb stance (SLS) is a demanding postural task, widely used for balance assessment in both research and clinical practice. Despite extensive data on elderly populations, less known about younger healthier adults. Our aim this study was to assess during SLS task among cohort of healthy adults determine whether there are age or sex group testing condition differences performances. In cross-sectional study, we involved 120 participants aged 30–65 years divided them into four sub-groups...
Background Hamstring strain injuries (HSIs) are among the most common in football, causing significant time-loss and impacting player performance. Despite various preventive strategies, incidence of HSIs remains high, necessitating evidence-based approaches to reduce injury rates. Objective This scoping review aims evaluate effectiveness Nordic Exercise (NHE) reducing recurrence football players provide practical recommendations for its implementation. Methods A comprehensive literature...
Introduction Recent evidence suggests that GSK3 activity is chondroprotective in osteoarthritis (OA), but at the same time, its inactivation has been proposed as an anti-inflammatory therapeutic option. Here we evaluated extent of GSK3β vivo OA knee cartilage and molecular events downstream vitro to assess their contribution cell senescence hypertrophy. Methods In level phosphorylated was analyzed oxidative damage assessed by 8-oxo-deoxyguanosine staining. The effects (using either LiCl or...