A5072319434- Adrenal Hormones and Disorders
- Cancer Immunotherapy and Biomarkers
- Estrogen and related hormone effects
- CAR-T cell therapy research
- Peripheral Artery Disease Management
- Nerve Injury and Rehabilitation
- Cancer Treatment and Pharmacology
- Advanced Breast Cancer Therapies
- Metabolism and Genetic Disorders
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Birth, Development, and Health
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Epigenetics and DNA Methylation
- Hybrid Renewable Energy Systems
- Histone Deacetylase Inhibitors Research
- Peripheral Nerve Disorders
- Lung Cancer Treatments and Mutations
- Neurofibromatosis and Schwannoma Cases
- PI3K/AKT/mTOR signaling in cancer
- Spinal Dysraphism and Malformations
- Adrenal and Paraganglionic Tumors
- Radiomics and Machine Learning in Medical Imaging
- 14-3-3 protein interactions
Kyushu University
1999-2024
Sakai Chemical Industry (Japan)
2021
AstraZeneca (Switzerland)
2012
Sapporo Azabu Neurosurgical Hospital
2001-2009
Hokkaido University
1993-2009
AstraZeneca (Japan)
2003
Kyoto University
1999
Roche (Switzerland)
1998
Society for Leukocyte Biology
1998
Bayer (United States)
1998
Abstract Establishment of the DNA methylation landscape mammalian oocytes, mediated by DNMT3A-DNMT3L complex, is crucial for reproduction and development. In mouse high levels occur exclusively in transcriptionally active regions, with moderate to low other regions. Histone H3K36me3 mediates transcribed regions; however, it unknown which histone mark guides Here, we show that, H3K36me2 highly enriched X chromosome broadly distributed across all autosomes. Upon depletion, moderately...
Nivolumab, an anti–PD-1 antibody, is now considered important therapeutic agent in several advanced malignancies. However, immune-related adverse events such as endocrinopathies have been reported with its use. Thyroid disorder and isolated adrenocorticotropic hormone deficiency frequently nivolumab-induced events. Another endocrinopathy type 1 diabetes mellitus (T1DM), described rapid onset complete insulin insufficiency, at times leading to fulminant T1DM. We report the case of a...
We investigated the effect of interleukin-13 (IL-13) on production IL-1 receptor antagonist (IL-1ra) and proinflammatory cytokines by human alveolar macrophages (AM). AM were obtained bronchoalveolar lavage from healthy donors. The IL-1ra cytokines, such as beta, IL-6, tumor necrosis factor-alpha (TNF-alpha), quantitated enzyme immunoassays. spontaneously produced IL-1ra, this was significantly augmented IL-13. On other hand, IL-13 alone did not affect freshly isolated AM. Upon stimulation...
Interleukin-4 (IL-4) has previously been found to downregulate interleukin-1 (IL-1) production, but upregulate the production of IL-1 receptor antagonist (IL-1ra) in human monocytes stimulated with lipopolysaccharide (LPS). In present study we wanted determine whether IL-1ra and alveolar macrophages (AMs) is regulated differently at protein messenger ribonucleic acid (mRNA) levels by IL-4 interferon-gamma (IFN-gamma). AMs obtained from healthy donors bronchoalveolar lavage centrifugal...
Nivolumab, an anti-programmed cell death-1 monoclonal antibody, has improved the survival of patients with malignant melanoma. Despite its efficacy, nivolumab inconsistently induces thyroid dysfunction as immune-related adverse event (irAE). This study aimed to evaluate nivolumab-induced determine risks and mechanisms irAEs.After excluding 10 patients, data 24 melanoma (aged 17-85 years; 54% female) were retrospectively analyzed.Thyroid irAEs observed in seven (29%). Three had hypothyroidism...
Bone and vascular diseases are considered to share pathogenic mechanisms. Excess glucocorticoids, key regulators of cardiovascular metabolic homeostasis, may promote both simultaneously. We used endogenous Cushing's syndrome (CS) investigate whether glucocorticoid excess underlies coexisting bone diseases. included 194 patients with adrenal tumors (ATs): autonomous cortisol secretion (ACS, n = 97) non-functional AT (n 97). ACS was further classified into overt CS 17) subclinical (SCS, 80)....
BACKGROUND:Ipilimumab is a therapeutic human monoclonal antibody that targets the T-cell inhibitory molecule, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and classified as an immune checkpoint inhibitor has been shown to improve prognosis in patients with advanced melanoma. However, several immune-related adverse events have reported be associated ipilimumab Treatment. A case of acute exacerbation chronic adrenal insufficiency presented highlights glucocorticoid dosage for undergoing steroid...
The V-l and polarization characteristics were measured for the solid oxide fuel cell with intemal re-fo㎜ing ofmethane，Akhough metallic surface area ofNi was low Ni-YSZ ce㎜et prepared by reduction ofNiO-YSZ，the actMty forsteamrefomingreaction washighto attainequilibrium conversion at lOOO。C high operation temperature not only reduced reslstance but also attained ofmethane selectivity to CO，The changes in selectivitles CO
Abstract Disclosure: S. Yano: None. N. Sato: H. Araki: F. Miura: T. Ito: Y. Ogawa: The mammalian liver serves as an extramedullary hematopoietic organ during the fetus and matures into a metabolic after birth, adapting to changes in nutritional environment. DNA demethylation upregulates fatty acid β-oxidation (FAO) genes postnatal mouse produce energy from breast milk lipids. However, detailed interactions between methylation (DNAme) gene expression through perinatal stages remain poorly...
Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported patients with primary pigmented nodular adrenocortical disease. Here, we describe first case subclinical Cushing's syndrome represented by autonomous secretion and administration, harboring an activating mutation α subunit stimulatory G protein (GNAS). A 65-year-old woman was diagnosed during evaluation for bilateral adrenal masses. Tumors unknown origin were...
Purpose: Bone and vascular diseases are considered to share pathogenic mechanisms. Excess glucocorticoids, key regulators of cardiovascular metabolic homeostasis, may promote both simultaneously. We used endogenousCushing's syndrome (CS) investigate whether glucocorticoid excess underlies coexisting bone diseases.Methods: included 194 patients with adrenal tumors (ATs): autonomous cortisol secretion (ACS, n=97) non-functional AT (n=97). ACS was further classified into overt CS (n=17)...