A5088174367- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Reproductive Physiology in Livestock
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Diabetes Management and Research
- Hormonal and reproductive studies
- Cancer Immunotherapy and Biomarkers
- Liver Disease Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Metabolism, Diabetes, and Cancer
- Growth Hormone and Insulin-like Growth Factors
- Medical Imaging Techniques and Applications
- Bone health and treatments
- CAR-T cell therapy research
- Diet and metabolism studies
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Effects of Environmental Stressors on Livestock
- Acute Lymphoblastic Leukemia research
- Adenosine and Purinergic Signaling
- Animal Behavior and Welfare Studies
Kurume University
2018-2024
Kurume University Hospital
2024
Shimada Municipal Hospital
2022
Kyushu University
2004-2021
Saga University
2012-2020
Fukuoka University
2010-2018
Saga Medical School Hospital
2013
Electronic Navigation Research Institute
2011
Osaka Medical and Pharmaceutical University
2003-2009
Okayama University
2007
OBJECTIVE To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) a multi-institutional cohort study Japan. RESEARCH DESIGN AND METHODS The was determined 2,210 PA (diagnosed or glycated hemoglobin [HbA1c] ≥6.5% [≥48 mmol/mol]; NGSP) compared that Japanese general population according to age sex. In 1,386 clear laterality (unilateral bilateral), effects plasma aldosterone concentration (PAC), hypokalemia (<3.5 mEq/L), suspected subclinical...
Nivolumab, an anti-programmed death-1 antibody, is a breakthrough treatment for several malignancies. Its specific adverse effects caused by autoimmunity are termed immune-related events, which involve endocrine dysfunctions. Herein, we report two cases of isolated adrenocorticotropic hormone (ACTH) deficiency induced nivolumab the metastatic malignant melanoma. Case 1 was 39-year-old man and 2 50-year-old woman, both whom presented with progressive After 13 courses administration, were...
Glucagon-like peptide-1 (GLP-1) receptor agonists are used to treat diabetes, but their effects on nonalcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) remain unclear. In this study, mice with streptozotocin- high-fat diet-induced diabetes NASH were subcutaneously treated liraglutide or saline (control) for 14 weeks. Glycemic control, hepatocarcinogenesis, liver histology compared between groups. Fasting blood glucose levels significantly lower in group...
The aim of this study was to investigate the impact adrenal venous sampling (AVS) lateralization cutoffs on surgical outcomes.Cosyntropin-stimulated AVS used guide management 377 patients with primary aldosteronism (PA) who were evaluated 6 months after surgery.The proportion that achieved clinical benefit and complete biochemical success based aldosterone index (LI) determined.Clinical in 29 47 an LI between 2 4, 66 101 4 10, 158 203 > 10 (P < 0.01 for trend). Complete 27 42 60 76 127 155 =...
It is currently unclear whether sodium-glucose co-transporter 2 (SGLT2) inhibitor administration can improve the insulin sensitivity as well rapidly reduce plasma glucose concentrations in humans during early phase of treatment initiation. This study aimed to investigate effect SGLT2 on initiation.This single-center, open label, and single-arm prospective recruited 20 patients (14 men) with type diabetes mellitus (T2DM). We examined patients' metabolic parameters before 1 week after (10...
Abstract Context 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors demonstrate antimetabolic and antisarcopenic effects in Cushing’s syndrome (CS) autonomous cortisol secretion (ACS) patients. Objective To confirm the efficacy safety of S-707106 (11β-HSD1 inhibitor) administered to CS ACS Design A 24-week single-center, open-label, single-arm, dose-escalation, investigator-initiated clinical trial on a database. Setting Kyushu University Hospital, Kurume related facilities....
Eruptive xanthomas are skin manifestations associated with hypertriglyceridemia. Accordingly, the improvement of hypertriglyceridemia can ameliorate this condition. We report a case patient type 2 diabetes mellitus who was diagnosed lesion. Clinicians should be aware that eruptive could indicate metabolic disorders atherosclerosis.
Nivolumab, an anti–PD-1 antibody, is now considered important therapeutic agent in several advanced malignancies. However, immune-related adverse events such as endocrinopathies have been reported with its use. Thyroid disorder and isolated adrenocorticotropic hormone deficiency frequently nivolumab-induced events. Another endocrinopathy type 1 diabetes mellitus (T1DM), described rapid onset complete insulin insufficiency, at times leading to fulminant T1DM. We report the case of a...
Pituitary tumor transforming gene (PTTG) is a proto-oncogene cloned from rat GH4 cells. This was able to induce cell transformation in vitro and also associated with p53-dependent -independent apoptosis. In this study, we human PTTG (hPTTG) pituitary then stably transfected the hPTTG into HeLa A549 An overexpression of significantly inhibited growth, which determined by adherent growth properties, colony formation soft agar [3H] thymidine incorporation, respectively, The inhibitory effect on...
While the over-expression of tumor suppressor programmed cell death 4 (PDCD4) induces apoptosis, it was recently shown that PDCD4 knockdown also induced apoptosis. In this study, we examined cycle regulators whose activation is affected by to investigate contribution regulation in three types hepatoma cells: HepG2, Huh7 (mutant p53 and p16-deficient), Hep3B (p53- Rb-deficient). suppressed growth all lines inhibiting Rb phosphorylation via down-regulating expression itself CDKs, which...
Abstract The vesicular nucleotide transporter (VNUT) is responsible for the storage and release of ATP from various ATP-secreting cells, it plays an essential role in purinergic signaling. Although extracellular its degradation products are known to mediate inflammatory responses via purinoceptors, whether affects steatohepatitis acute liver injury far less understood. In present study, we investigated effects clodronate, a potent selective VNUT inhibitor, on chronic inflammation mice. model...
Nivolumab, an anti-programmed cell death-1 monoclonal antibody, has improved the survival of patients with malignant melanoma. Despite its efficacy, nivolumab inconsistently induces thyroid dysfunction as immune-related adverse event (irAE). This study aimed to evaluate nivolumab-induced determine risks and mechanisms irAEs.After excluding 10 patients, data 24 melanoma (aged 17-85 years; 54% female) were retrospectively analyzed.Thyroid irAEs observed in seven (29%). Three had hypothyroidism...
Objectives: The high-mobility group A protein 1a (HMGA1a) is known as a transcription factor that binds to DNA, but recent studies have shown it exerts novel functions through RNA-binding. We were prompted decipher the mechanism of HMGA1a-induced alternative splicing estrogen receptor alpha (ERα) we recently reported would alter tamoxifen sensitivity in MCF-7 TAMR1 cells. Methods: Endogenous expression full length ERα66 and its isoform ERα46 evaluated breast cancer cells by transient HMGA1a...