A5101962150- Orthopaedic implants and arthroplasty
- Neuroinflammation and Neurodegeneration Mechanisms
- Total Knee Arthroplasty Outcomes
- Spinal Cord Injury Research
- Neurogenesis and neuroplasticity mechanisms
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
- Planarian Biology and Electrostimulation
- Knee injuries and reconstruction techniques
- Cardiovascular and Diving-Related Complications
- MicroRNA in disease regulation
- Electromagnetic Fields and Biological Effects
- Osteoarthritis Treatment and Mechanisms
- Immune cells in cancer
- Calpain Protease Function and Regulation
- Magnetic and Electromagnetic Effects
- RNA Interference and Gene Delivery
- Zebrafish Biomedical Research Applications
- Orthopedic Infections and Treatments
- Graphene and Nanomaterials Applications
- Hippo pathway signaling and YAP/TAZ
- High Altitude and Hypoxia
Second Hospital of Anhui Medical University
2017-2024
Anhui Medical University
2017-2024
Lactate-derived histone lactylation is involved in multiple pathological processes through transcriptional regulation. The role of lactate-derived the repair spinal cord injury (SCI) remains unclear. Here we report that overall lactate levels and are upregulated after SCI. Notably, H4K12la was significantly elevated microglia injured cord, whereas exogenous treatment further Functionally, promoted microglial proliferation, scar formation, axon regeneration, locomotor function recovery...
Bone integration on the surface of titanium prosthesis is critical to success implant surgery. Good at contact interface basis long-term stability. TiO2 nanotubes have become one most commonly used modification techniques for artificial joint prostheses and bone defect implants due their good biocompatibility, mechanical properties chemical can promote F-actin polymerization in mesenchymal stem cells (BMSCs) osteogenic differentiation. The possibility as an upstream part regulate GCN5...
Low frequency pulsed electromagnetic field (LFPEMF) has been shown to provide anti-inflammatory and antioxidative effects. However, there are no reports on whether LFPEMF can treat spinal cord injury (SCI) its therapeutic mechanism. Therefore, this study was conducted investigate promote the recovery of neurological function after SCI in rats Basso-Beattie-Bresnahan (BBB) score transcranial magnetic motor-evoked potentials (tcMMEPs) were recorded assess function. Hematoxylin eosin (HE)...
Bone marrow mesenchymal stem cells (BMSCs) play a critical role in bone formation and are extremely sensitive to external mechanical stimuli. Mechanical signals can regulate the biological behavior of on surface titanium-related prostheses inducing osteogenic differentiation BMSCs, which provides integration host prosthesis benefits. But mechanism is still unclear. In this study, BMSCs planted TiO2 nanotubes were subjected cyclic stress, related mechanisms explored. The results alkaline...
Recent research indicates that after spinal cord injury (SCI), microglia accumulate at the borders of lesions between astrocytic and fibrotic scars perform inflammation-limiting neuroprotective functions, however, mechanism microglial migration remains unclear. Fascin-1 is a key actin-bundling protein regulates cell migration, invasion adhesion, but its role during SCI has not been reported. Here, we found 7-14 days in mice, significantly upregulated, mainly distributed around lesion,...
Valgus knee, which causes severe dysfunction and seriously affects the quality of life patients, is a condition affecting 10% of patients who undergo total knee arthroplasty (TKA). The best choice surgical approach method release soft tissue, however, still unclear. Therefore, aim present study was to investigate clinical efficacy lateral parapatellar with iliotibial band (ITB) dissection from Gerdy tubercle for TKA in valgus knees. In total, 56 patients (25 males...
Following spinal cord injury (SCI), microglia gradually migrate to the edge of lesion, interweaving around border lesion form microglial scar, which performs inflammatory limiting and neuroprotective functions. Recent reports showed that Yes-associated protein (YAP) was expressed in astrocytes promoted formation astrocytic scars, while YAP not after SCI. its paralogue transcriptional coactivator with PDZ-binding motif (TAZ) are coactivators, have a similar functional role as both negatively...
The knee joint of hemophiliacs may face the result local morphological changes due to long-term irritation synovitis. This study aims elucidate characteristics distal femur in hemophilic arthritis (HA) and compare compatibility three types prostheses with anteroposterior (AP) mediolateral (ML) dimensions femoral osteotomy surface.
Abstract The imbalance in the proportion of M1/M2 macrophage polarization is a crucial contributor to persistent progression osteoarthritis (OA). This study aimed evaluate effects low-dose biocompatible ionized air (BIA) on and its subsequent chondroprotective effects, thereby validating potential BIA slowing OA. In vitro experiments demonstrated that modulates M1 macrophages toward M2 phenotype via ROS-mediated STAT6 pathway. shift reduces expression pro-inflammatory mediators while...