A5048346083- Polymer Surface Interaction Studies
- Semiconductor materials and devices
- Metal-Organic Frameworks: Synthesis and Applications
- American Environmental and Regional History
- Semiconductor Quantum Structures and Devices
- Ferroelectric and Negative Capacitance Devices
- Advancements in Semiconductor Devices and Circuit Design
- American History and Culture
- Quantum and electron transport phenomena
- Nanoplatforms for cancer theranostics
- Electrospun Nanofibers in Biomedical Applications
- Angiogenesis and VEGF in Cancer
- Mesenchymal stem cell research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced biosensing and bioanalysis techniques
- Dendrimers and Hyperbranched Polymers
- Molecular Junctions and Nanostructures
- Advanced Semiconductor Detectors and Materials
- Nanofabrication and Lithography Techniques
- Nanoparticle-Based Drug Delivery
- Heart Failure Treatment and Management
- Wound Healing and Treatments
- Silicon and Solar Cell Technologies
- Tissue Engineering and Regenerative Medicine
- Advanced Memory and Neural Computing
Cornell University
2023-2024
Weill Cornell Medicine
2024
Medizinische Hochschule Hannover
2022-2024
Chinese University of Hong Kong
2018-2023
Beth Israel Deaconess Medical Center
2023
Federal Institute For Materials Research and Testing
2016-2023
Presbyterian Hospital
2023
New York Hospital Queens
2023
NewYork–Presbyterian Hospital
2023
GlobalFoundries (Germany)
2016-2022
We show the implementation of a ferroelectric field effect transistor (FeFET) based eNVM solution into leading edge 22nm FDSOI CMOS technology. Memory windows 1.5 V are demonstrated in aggressively scaled FeFET cells with an area as small 0.025 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> At this point program/erase endurance cycles up to 10 xmlns:xlink="http://www.w3.org/1999/xlink">5</sup> supported. Complex pattern written 32...
We successfully implemented a one-transistor (1T) ferroelectric field effect transistor (FeFET) eNVM into 28nm gate-first super low power (28SLP) CMOS technology platform using two additional structural masks. The electrical baseline properties remain the same for FeFET integration and JTAG-controlled 64 kbit memory shows clearly separated states. High temperature retention up to 250 °C is demonstrated endurance 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Pericytes play a crucial role in angiogenesis and vascular maintenance. They can be readily identified vivo isolated as CD146(+)CD34(-) cells from various tissues. Whether these other markers reliably identify pericytes vitro is unclear. selected exhibit multilineage potential. Thus, their perivascular location might represent stem cell niche. This has spurred assumptions that not only all are mesenchymal stromal (MSCs), but also MSCs act pericytes. Considering this hypothesis, we developed...
Inspired by the game of “pinball” where rolling metal balls are guided obstacles, here we describe a novel microfluidic technique which utilizes micropillars in flow channel to continuously generate, encapsulate and guide Layer-by-Layer (LbL) polyelectrolyte microcapsules. Droplet-based techniques were exploited generate oil droplets smoothly along row repeatedly travel through three parallel laminar streams consisting two polymers washing solution. Devices prototyped PDMS generated highly...
The melting behaviour of metal-organic frameworks (MOFs) has aroused significant research interest in the areas materials science, condensed matter physics and chemical engineering. This work first introduces a novel method to fabricate bimetallic MOF glass, through melt-quenching cobalt-based zeolitic imidazolate framework (ZIF) [ZIF-62(Co)] with an adsorbed ferric coordination complex. high-temperature chemically reactive ZIF-62(Co) liquid facilitates formation coordinative bonds between...
Metal-Organic Frameworks (MOFs) have emerged as a novel component in biomaterial formulations over the past 5 years. The bioactivity of MOFs bone or cartilage tissue is mediated through sustained delivery metal ions, bioactive ligands, drug molecules that are loaded into porous MOF structures. Alternatively, may also originate from structure-specific properties. latter includes availability and accessibility open coordination sites for catalytic conversion biomolecules active agents. This...
The effectiveness of nanoparticles (NP) in nanomedicine depends on their ability to extravasate from vasculature towards the target tissue. This is determined by permeability across endothelial barrier. Unfortunately, a quantitative study diffusion coefficients (Pd) NPs difficult with vivo models. Here, we utilize relevant model vascular-tissue interface tunable vitro based microfluidics. Human umbilical vein cells (HUVECs) grown microfluidic devices were treated Angiopoietin 1 and cyclic...
The buffering effects displayed by pH-responsive polymers have recently gained attention in diverse fields such as nanomedicine and water treatment. However, creating libraries of modular versatile that can be readily integrated within existing materials remains challenging, hence restricting applications inspired their capacity. Herein, we propose the use metal–phenolic networks (MPNs) tunable systems through mechanistic studies show are driven pH-responsive, multivalent coordination. Owing...
HfO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -based ferroelectric FETs (FeFETs) offer excellent retention, scalability, and memory window. However, achieving high endurance is still challenging. Here, a fluorination treatment presented that enables significant device stability improvement. Noise charge pumping methods are applied to obtain deeper understanding of the underlying defect interaction in FeFETs.
Successful vascularization is essential in wound healing, the histo-integration of biomaterials, and other aspects regenerative medicine. We developed a functional vitro assay to dissect complex processes directing angiogenesis during whereby vascular cell spheroids were induced sprout presence classically (M1) or alternatively (M2) activated macrophages. This simulated microenvironment, which sprouting cells exposed inflammatory proliferation phases respectively. showed that M1 macrophages...
Pericytes reside within the basement membrane of small vessels and are often in direct cellular contact with endothelial cells, fulfilling important functions during blood vessel formation homeostasis. Recently, these pericytes have been also identified as mesenchymal stem cells. Mesenchymal especially their specialized subpopulation pericytes, represent promising candidates for therapeutic angiogenesis applications, already widely applied pre-clinical clinical trials. However, cell-based...
Abstract Light‐driven directional motion is common in nature but remains a challenge for synthetic microparticles, particularly regarding collective on macroscopic scale. Successfully engineering microparticles with light‐driven could lead to breakthroughs drug delivery, contaminant sensing, environmental remediation, and artificial life. Herein, metal–phenolic particle microswimmers capable of autonomously sensing swimming toward an external light source are reported, the speed regulated by...
Autologous cells hold great potential for personalized cell therapy, reducing immunological and risk of infections. However, low counts at harvest with subsequently long expansion times associated function loss currently impede the advancement autologous therapy approaches. Here, we aimed to source clinically relevant numbers proangiogenic from an easy accessible source, namely peripheral blood. Using macromolecular crowding (MMC) as a biotechnological platform, derived novel type blood that...
Abstract Zeolitic Imidazolate Frameworks (ZIFs) are crystalline materials that comprise of metal nodes and Imidazole derivatives as linkers. ZIF‐67 is often used in polymer composite e. g. for gas separation membranes. Post‐synthesis treatment crystals with ultrasound leads to unforeseen plasticity resulted sintered nano‐flakes. Consequently, increases the external surface area which might improve blending polymers materials. These new morphologies were characterized by transmission...
We report on a novel method for the encapsulation of highly water soluble materials by using layer-by-layer (LbL) polyelectrolyte self-assembly. State art self-assembly LbL coating and methods are only applicable to insoluble or poorly template materials, because process is performed in causing dissolution solid template. Our extends material spectrum non-ionized polyelectrolytes an organic phase (reverse-phase) instead salts aqueous environment. By reverse-phase (RP-LbL) technique, we have...
The endothelial glycocalyx forms the inner-most lining of human microvasculature. It ensures physiological function blood vessels and plays a crucial role in occurrence progression microvascular diseases. present communication aims to highlight usefulness high-resolution imaging lectin (Bandeiraea Simplicifolia) stained 3-dimensional microfluidic cell cultures. system allowed visualizing cancer extravasation, which is key event metastasis formation pathologies. In brief, networks were...
The ferroelectric HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> based field effect transistor (FeFET) has been under research for many years and shows unique properties applications in the of emerging memories in-memory computing. This work first time demonstrates how a target programming algorithm can improve FeFET device characteristics with respect to endurance performance variability small geometries. With this technique...
Due to their favorable properties and high porosity, zeolitic imidazolate frameworks (ZIFs) have recently received much limelight for key technologies such as energy storage, optoelectronics, sensorics, catalysis. Despite widespread interest in these materials, fundamental questions regarding the zinc coordination environment remain poorly understood. By focusing on zinc(II)2-methylimidazolate (ZIF-8) its tetrahedrally coordinated analogues with Br-, Cl-, H-substitution 2-ring position, we...
In the quest for greater control over biomacromolecular loading and higher encapsulation efficiencies biomacromolecule loaded microcapsules we devised a novel approach employing water soluble sacrificial templates. traditional layer by (LbL) methods, aqueous solutions of polyelectrolyte salts in combination with insoluble template materials are used to prepare that can be biomacromolecules. Here, replaced phase pure aliphatic alcohols (Reversed-Phase) greatly enhance retention cargo close...