A5012575642- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Chromatin Remodeling and Cancer
- Multiple Myeloma Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- Histone Deacetylase Inhibitors Research
- MXene and MAX Phase Materials
- Immunotherapy and Immune Responses
- HIV/AIDS drug development and treatment
- Advanced Image Processing Techniques
- Cancer Mechanisms and Therapy
- Image and Signal Denoising Methods
- Lung Cancer Research Studies
- Extracellular vesicles in disease
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Antimicrobial Peptides and Activities
- Chronic Lymphocytic Leukemia Research
- Synthesis and Biological Evaluation
- T-cell and B-cell Immunology
- Image Processing Techniques and Applications
- Pharmacological Receptor Mechanisms and Effects
- Calcium signaling and nucleotide metabolism
Wuhan University
2020-2025
Dana-Farber Cancer Institute
2017-2024
Harvard University
2018-2024
China Medical University
2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2023
Universitat de Barcelona
2023
Sheng Jing Hospital
2023
York University
2020
Hong Kong Polytechnic University
2019
ETH Zurich
2019
This paper reviews the 2nd NTIRE challenge on single image super-resolution (restoration of rich details in a low resolution image) with focus proposed solutions and results. The had 4 tracks. Track 1 employed standard bicubic downscaling setup, while Tracks 2, 3 realistic unknown downgrading operators simulating camera acquisition pipeline. were learnable through provided pairs high train images. tracks 145, 114, 101, 113 registered participants, resp., 31 teams competed final testing...
This paper reviewed the 3rd NTIRE challenge on single-image super-resolution (restoration of rich details in a low-resolution image) with focus proposed solutions and results. The had 1 track, which was aimed at real-world single image problem an unknown scaling factor. Participants were mapping images captured by DSLR camera shorter focal length to their high-resolution longer length. With this challenge, we introduced novel dataset (RealSR). track 403 registered participants, 36 teams...
This paper reviews the NTIRE 2020 challenge on real image denoising with focus newly introduced dataset, proposed methods and their results. The is a new version of previous 2019 that was based SIDD benchmark. collected validation testing datasets, hence, named SIDD+. has two tracks for quantitatively evaluating performance in (1) Bayer-pattern rawRGB (2) standard RGB (sRGB) color spaces. Each track ~250 registered participants. A total 22 teams, proposing 24 methods, competed final phase...
Abstract Anti-CD38 monoclonal antibodies like Daratumumab (Dara) are effective in multiple myeloma (MM); however, drug resistance ultimately occurs and the mechanisms behind this poorly understood. Here, we identify, via two vitro genome-wide CRISPR screens probing resistance, KDM6A as an important regulator of sensitivity to Daratumumab-mediated antibody-dependent cellular cytotoxicity (ADCC). Loss leads increased levels H3K27me3 on promoter CD38 , resulting a marked downregulation...
Immunogenic cell death (ICD) is a form of by which cancer treatments can induce clinically relevant antitumor immune response in broad range cancers. In multiple myeloma (MM), the proteasome inhibitor bortezomib an ICD inducer and creates durable therapeutic responses patients. However, eventual relapse resistance to appear inevitable. Here, integrating patient transcriptomic data with analysis calreticulin (CRT) protein interactors, we found that GABA type A receptor-associated (GABARAP)...
Multiple myeloma (MM) is an incurable cancer that derives pro-survival/proliferative signals from the bone marrow (BM) niche. Novel agents targeting not only cells, but also BM-niche have shown greatest activity in MM. Histone deacetylases (HDACs) are therapeutic targets MM and we previously showed HDAC3 inhibition decreases proliferation both alone co-culture with stromal cells (BMSC). In this study, investigate effects of BMSCs. Using BMSC lines as well patient-derived BMSCs, show...
Abstract Purpose: BRD9 is a defining component of the noncanonical SWI/SNF complex, which regulates gene expression by controlling chromatin dynamics. Although recent studies have found an oncogenic role for in multiple cancer types including myeloma, its clinical significance and mechanism not yet been elucidated. Here, we sought to identify biological impact may contribute development novel therapeutic strategies. Experimental Design: We performed integrated analyses vitro vivo using...
This paper reviews the first NTIRE challenge on perceptual image enhancement with focus proposed solutions and results. The participating teams were solving a real-world photo problem, where goal was to map low-quality photos from iPhone 3GS device same captured Canon 70D DSLR camera. considered problem embraced number of computer vision subtasks, such as denoising, resolution sharpness enhancement, color/contrast/exposure adjustment, etc. target metric used in this combined PSNR SSIM scores...
Background The global outbreak of COVID-19, and the limited availability clinical treatments, forced researchers around world to search for pathogenesis potential treatments. Understanding SARS-CoV-2 is crucial respond better current coronavirus disease 2019 (COVID-19) pandemic. Methods We collected sputum samples from 20 COVID-19 patients healthy controls. Transmission electron microscopy was used observe morphology SARS-CoV-2. Extracellular vesicles (EVs) were isolated supernatant VeroE6...
ABSTRACT The increase in bacterial resistance to minocycline and other tetracyclines poses a serious threat global public health. Because the development of new antibiotics has proven problematic, antibiotic sensitization therapy is now an effective coping strategy. While antimicrobial peptides generally exhibit broad-spectrum antibacterial activity good biocompatibility, naturally truncated portions (such as snake cathelicidin) often do not activity, their function remains unknown. FP-CATH9...
Abstract Purpose: Efforts are required to improve the potency and durability of CD38- BCMA-based immunotherapies in human multiple myeloma. We here delineated molecular cellular mechanisms underlying novel immunomodulatory effects triggered by BCMA pyrrolobenzodiazepine (PBD) antibody drug conjugate (ADC) MEDI2228 which can augment efficacy these immunotherapies. Experimental Design: MEDI2228-induced transcriptional protein changes were investigated define significantly impacted genes...
Intellectual disability (ID), one of the most common human developmental disorders, can be caused by genetic mutations in Cullin 4B (Cul4B) and cereblon (CRBN). CRBN is a substrate receptor for Cul4A/B-DDB1 ubiquitin ligase (CRL4) target voltage- calcium-activated BK channel ER retention. Here we report that ID-associated CRL4CRBN abolish interaction with CRL4, redirect to SCFFbxo7 proteasomal degradation. Glioma cell lines harbouring record density-dependent decrease currents, which...
Abstract Bortezomib (BTZ) is a standard-of-care treatment in multiple myeloma (MM); however, adverse side effects and development of resistance limit its long term benefit. To improve target specificity, therapeutic efficacy, overcome resistance, we designed nanoparticles that encapsulate BTZ are surface-functionalized with BCMA antibodies (BCMA-BTZ-NPs). We confirmed efficient cellular internalization the BCMA-BTZ-NPs only BCMA-expressing MM cells, but not BCMA-knockout (KO) cells. In...
In the present study, an Escherichia coli-expressed yeast ribosomal protein was used as a template for synthesizing RPL14B-based CdSe quantum dots in vitro via quasi-biosynthesis strategy at low temperature. The synthetic bionic were characterized using TEM, HRTEM, and EDX spectra, results showed that synthesized with crystal face spacing of 0.21 0.18 nm. biomimetic method-synthesized exhibited characteristics uniform particle size, good dispersion, strong photobleaching resistance....