A5020959455- Reproductive Biology and Fertility
- Electromagnetic Fields and Biological Effects
- Ovarian function and disorders
- Testicular diseases and treatments
- Medical and Biological Ozone Research
- Sperm and Testicular Function
- Cancer-related Molecular Pathways
- Wound Healing and Treatments
- Nerve Injury and Rehabilitation
- Laser Applications in Dentistry and Medicine
- Facial Nerve Paralysis Treatment and Research
- Bone health and treatments
- Nerve injury and regeneration
- Spine and Intervertebral Disc Pathology
- Spaceflight effects on biology
- Urinary Bladder and Prostate Research
- Organ Transplantation Techniques and Outcomes
- Transcranial Magnetic Stimulation Studies
- Management of metastatic bone disease
- Hypothalamic control of reproductive hormones
- Bone and Dental Protein Studies
- Urinary Tract Infections Management
- Electron Spin Resonance Studies
- Eicosanoids and Hypertension Pharmacology
- PARP inhibition in cancer therapy
Mersin Üniversitesi
2006-2024
Massachusetts Eye Research and Surgery Institute
2023-2024
Dr. Behçet Uz Çocuk Hastalıkları Hastanesi
2006
Ozone may promote moderate oxidative stress, which increases antioxidant endogenous systems. There are a number of antioxidants that have been investigated therapeutically for improving peripheral nerve regeneration. However, no previous studies reported the effect ozone therapy on facial regeneration.We aimed to evaluate regeneration.Fourteen Wistar albino rats were randomly divided into two groups with experimental crush injuries: control group, received saline treatment post-crush, and an...
Alcohol-induced lung damage may be associated with increased oxidative stress.Our aim was to investigate alcohol-induced changes in the biochemistry and histopathology of lung.Rats were divided into two groups, a control group an ethanol group. The received 2 g/kg (total: 3 ml) intraperitoneally. controls given same amount saline via route. Three hours later, rats sacrificed, blood tissue samples obtained. Oxidative stress assessed by measuring levels erythrocyte reduced glutathione (GSH),...
Polycystic ovary syndrome is the most frequently seen endocrine disorder in women of reproductive age with a prevalence about 10%.To investigate efficiency growth differentiation factor 9 and bone morphogenetic protein 15 during folliculogenesis dehydroepiandrosterone-induced mouse model.Animal experimentation.Mice were divided into 3 groups: control, vehicle syndrome. model mice developed by injection dehydroepiandrosterone dissolved 0.1 mL sesame oil. Ovarian tissues examined for using...
The purpose of this study was to investigate the effect tamoxifen citrate on bladder functions and histology, also role estrogen receptor beta (ER beta) in a rat chemical cystitis model.The included 37 female Sprague-Dawley rats. Chemical induced by intravesical instillation hydrochloric acid 32 rats, treatment group (n = 15) received daily 0.4 mg/kg with orogastric tube, control 17) no treatment. sham consisted five rats having Cystometric studies were performed all at beginning end...
Endometrial cancer is the most common of female reproductive system. Perifosine has shown anti-tumor activity in a variety cancers by inhibition AKT phosphorylation. The active metabolite vitamin D (1,25(OH)2D3) anti-proliferative and pro-apoptotic properties recognized as an agent with great potential for intervention. Combination treatment specific agents been widely used targeted therapy cancer. In this study, we aimed to investigate anti-apoptotic effect varying concentrations perifosine...
Interferon-α has been used in various diseases at the reproductive ages. However, effect of interferon-α on testicular histology not studied literature. The aim this study was to investigate effects interferon α-2B including spermatogenesis a rat model. Seventeen adult male Wistar albino rats were divided into 3 groups: Six received 7.500 units (5 MIU/m2) (Intron), considered clinical treatment dose range. 30.000 (20 high dose. Five served as control group receiving 0.5 mL saline injection....
Abstract Purpose: The aim of the present study was to evaluate electrophysiological, biochemical and ultrastructural changes on rat sciatic nerve after radiotherapy.Thirty male Wistar albino rats were divided into three groups as: Control group (n = 10), Group I: 3 months radiotherapy II: 6 10). Groups I II irradiated with a (60)Co gamma source. A dose 20 Gy in 10 fractions applied II. Compound motor action potentials (CMAP) recorded all groups. Superoxide dismutase (SOD) catalase (CAT)...
The nervous system is an important target of radiofrequency (RF) radiation exposure since it the excitable component that potentially able to interact with electromagnetic fields. present study was designed investigate effects 1,800 MHz RF and protective role paricalcitol on rat sciatic nerve. Rats were divided into four groups as control, paricalcitol, RF, + paricalcitol. In groups, rats exposed for 1 h per day 4 weeks. Control kept under same conditions without application. given 0.2...
Endometrial cancer is the most common of female reproductive system. Combination treatment with specific agents has been widely used as a targeted therapy for cancer. In this study, we aimed to investigate anti-proliferative and apoptotic effects varying concentrations perifosine vitamin D on human endometrial cell line (HEC-1A). HEC-1A cells were exposed (10 μM, 30 μM), (50 nM, 200 nM) combinations both 48 h 72 h. Monitoring proliferation in time-dependent manner was performed xCELLigence...
OBJECTIVE: This study planned to evaluate the effects of vitamin A (VA) and steroid treatment on nerve healing. Study design: we investigated electrophysiological, electron microscopic (EM), immunohistochemical, biochemical findings in rat sciatic model. MATERIALS METHODS: In total, 112 female rats were divided into 16 groups, each consisting 7 animals. Subjects evaluated according compound muscle action potential (CMAP) findings, ultrastructural staging myelinated axons with EM, nitric...
The effects of an immunosuppressive agent, mycophenolate mofetil (MM), were investigated and compared with those methylprednisolone (MP) dexamethasone (DXM) on the traumatic nerve function.This is a randomized controlled animal study.This experimental study was performed 84 male Wistar albino rats. rats assigned to 12 groups each consisting 7 animals. formed according application normal-dose DXM (group 1A-B), high-dose MP 2A-B), 3A-B), MM 4A-B), combination therapies VA-B). Right sciatic...
Purpose: Atractylenolide III (ATR III) is known for its anti-inflammatory and neuroprotective activities. In this study, we aimed to investigate the effects of ATR on neuronal damage in temporal epileptic rats caused by kainic acid. Materials Methods: 16-week-old Wistar Albino were divided into three groups; control (C, n=8), acid (KA, III+ (KA+ATR, n=8). After 21 days injections acid, learning, memory behavior, anxiety, locomotor activity evaluated. Neuron morphologies hippocampus examined,...
This experimental study compared bony healing and cartilage degeneration following strut grafting trapdoor procedures for osteonecrosis of the femoral head in an ovine model. Osteonecrosis a defect were created surgically 16 hips 8 Merino sheep, index performed second session. Three months after surgery, treated by yielded better articular protection to groups. The group rest groups, but grafts osteochondral flaps failed unite with host bone. These findings indicate elevating flap during...
Objective: Burn may cause hypersensitivity towards infection, systemic inflammatory response syndrome, respiratory distress syndrome and multiple organ failure. Anti-inflammatory resistance infection effects of omega-3 (n-3) fatty acids was shown before. But their effect on inflammation wound healing after burn not investigated. 
 Methods: Seventy Wistar albino rats were used in the study. Fourteen without composed control group. Cutaneous created remaining 56 which received 50...