A5023578238- Biosensors and Analytical Detection
- Mosquito-borne diseases and control
- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Insect symbiosis and bacterial influences
- Nanopore and Nanochannel Transport Studies
- Bacteriophages and microbial interactions
- Anomaly Detection Techniques and Applications
- Respiratory viral infections research
- Animal Virus Infections Studies
- COVID-19 diagnosis using AI
- DNA and Nucleic Acid Chemistry
- Insect and Arachnid Ecology and Behavior
- Ion-surface interactions and analysis
- Viral gastroenteritis research and epidemiology
- IoT and Edge/Fog Computing
- CRISPR and Genetic Engineering
- DNA and Biological Computing
Firebird Biomolecular Sciences (United States)
2020-2024
Foundation for Applied Molecular Evolution
2014-2024
Zika, dengue, and chikungunya are three mosquito-borne viruses having overlapping transmission vectors. They cause diseases similar symptoms in human patients, but requiring different immediate management steps. Therefore, rapid (< one hour) discrimination of these patient samples trapped mosquitoes is needed. The need for speed precludes any assay that requires complex up-front sample preparation, such as extraction nucleic acids from the sample. Also precluded robust point-of-sampling...
Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including possibility of identifying, minutes, infected individuals as they enter spaces where must congregate a functioning society, workspaces, schools, points entry, and commercial business establishments. Here, only useful tests (a) require no sample transport, (b) minimal manipulation, (c) can be performed unlicensed individuals, (d) return results on spot much less than one hour, (e) cost more few dollars....
Zika, dengue, and chikungunya viruses are transmitted by mosquitoes, causing diseases with similar patient symptoms. However, they have different downstream patient-to-patient transmission potentials, require very treatments. Thus, recent Zika outbreaks make it urgent to develop tools that rapidly discriminate these in patients trapped select the correct treatment, understand manage their epidemiology real time. Unfortunately, current diagnostic tests, including those receiving 2016...
One horizon in synthetic biology seeks alternative forms of DNA that store, transcribe, and support the evolution biological information. Here, hydrogen bond donor acceptor groups are rearranged within a Watson–Crick geometry to get 12 nucleotides form 6 independently replicating pairs. Such artificially expanded genetic information systems (AEGIS) Darwinian vitro. To move AEGIS into living cells, metabolic pathways next required make triphosphates economically from their nucleosides,...
Zika, dengue, and chikungunya viruses are transmitted by mosquitoes, causing diseases with similar patient symptoms. However, they have different downstream patient-to-patient transmission potentials, require very treatments. Thus, recent Zika outbreaks make it urgent to develop tools that rapidly discriminate these in patients trapped select the correct treatment, understand manage their epidemiology real time. Unfortunately, current diagnostic tests, including those receiving 2016...
Described here are the synthesis, enzymology and some applications of a purine nucleoside analog (H) designed to have two tautomeric forms, one complementary thymidine (T), other cytidine (C). The performance H is compared by various metrics performances 'biversal' analogs that similarly rely on tautomerism complement both pyrimidines. These include (i) thermodynamic stability duplexes pair these biversals with standard nucleotides, (ii) ability support polymerase chain reaction (PCR), (iii)...
Abstract Managing the pandemic caused by SARS-CoV-2 requires new capabilities in testing, including possibility of identifying, minutes, infected individuals as they enter spaces where must congregate a functioning society, workspaces, schools, points entry, and commercial business establishments. Here, only useful tests (a) require no sample transport, (b) minimal manipulation, (c) can be performed unlicensed individuals, (d) return results on spot much less than one hour, (e) cost more few...
Arthropod-borne viruses are major causes of human and animal disease, especially in endemic low- middle-income countries. Mosquito-borne pathogen surveillance is essential for risk assessment vector control responses. Sentinel chicken serosurveillance (antibody testing) mosquito pool screening (by RT-qPCR or virus isolation) currently used to monitor arbovirus transmission, however substantial time lags seroconversion and/or laborious identification RNA extraction steps sacrifice their early...
Recently reported "displaceable probe" loop amplification (DP-LAMP) architecture has shown to amplify viral RNA from SARS-CoV-2 with little sample processing. The allows signals indicating the presence of target nucleic acids be spatially separated, and independent in sequence, complicated concatemer that LAMP processes create as part their process. This makes DP-LAMP an attractive molecular strategy integrate trap sampling innovations detect arboviruses carried by mosquitoes field. These...