A5101861210- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Bacterial biofilms and quorum sensing
- Synthesis and Characterization of Heterocyclic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Economic and Technological Developments in Russia
- Medical and Biological Ozone Research
- Synthesis and Biological Evaluation
- Business and Economic Development
- Microbial Community Ecology and Physiology
- Chemical Synthesis and Analysis
- Chemical Reaction Mechanisms
- Digital Economy and Transformation
- Synthesis and Reactions of Organic Compounds
- Engineering and Environmental Studies
- Chemical Synthesis and Reactions
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Economic and Business Development Strategies
- Digitalization and Economic Development in Agriculture
- Regional Economic Development and Innovation
- Inorganic and Organometallic Chemistry
- Erythrocyte Function and Pathophysiology
- Vibrio bacteria research studies
- Legionella and Acanthamoeba research
Ministry of Health of the Russian Federation
2011-2023
MIREA - Russian Technological University
2018-2022
Gamalei Institute of Epidemiology and Microbiology
2010-2021
Moscow Aviation Institute
2018-2020
Prokhorov General Physics Institute
2018
Lomonosov Moscow State University
2016
Academy of Medical Sciences
2008-2010
St. Petersburg State Technological Institute
2010
Russian Academy of Sciences
2008-2010
Moscow State University of Fine Chemical Technologies
2005
Using scanning electron microscopy techniques we measured the diameter of adhesive tubular appendages Salmonella enterica serovar S. Typhimurium. The interconnected bacteria in biofilms grown on gallstones or coverslips, attached to host cells (human neutrophils). appendage virulent flagellated C53 strain varied between 60 and 70 nm, thus considerably exceeding size flagella pili. Nonflagellated mutant SJW 880 coverslips were also by 60-90-nm appendages. Transmission studies thin sections...
This work is devoted to the study of two new synthetic bacteriochlorins with four and eight cationic substitutes as photosensitizers in photodynamic process. The spectral antibacterial properties these saline solution were investigated. It shown, that aggregation ability decreases efficiency grows substitute number increases.
ATP release from erythrocyte plays a key role in hypoxia-induced elevation of blood flow systematic circulation. We have previously shown that hemolysis contributes to triggered by several stimuli, including hypoxia, but the molecular mechanisms hypoxia-increased membrane fragility remain unknown.In this study, we compared action hypoxia on hemolysis, and composition membrane-bound proteins human erythrocytes.Twenty minutes incubation erythrocytes oxygen-free environment increased content...
Bacteriochlorins as the antimicrobial photosensitizers have a promising future in face of unrelenting increase resistance. The goal this study was to investigate infl uence lipophilicity and number positively charged substituents these molecules on photodynamic inactivation (PDI) biofi lm bacteria vitro. Testing how bacteriochlorin derivatives with different properties affect microbes will allow determine optimal ratio parameters within single molecule. We investigated 4 derivatives, all...
Literature data published since 1971 on the addition of nucleophiles to C=N bond most studied π-deficient six-membered heterocycles, viz. pyridine, pyrimidine and 1,3,5-triazine leading their transformation have been examined correlated. Possible applications proposed mechanisms for considered processes discussed. The bibliography contains 169 references.
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РезюмеКатионные бактериохлорины перспективны как антимикробные фотосенсибилизаторы для антибактериальной фотодинамической терапии.Настоящая работа посвящена изучению свойств нового наноструктурированного катионного фотосенсибилизатора на основе циклодекстриновой дисперсии производного бактериохлорина -метилового эфира 13 3 -N-(N-метилникотинил)бактериопурпуринимида (КБХ), с целью оптимизации состава и выбора интервала времени от введения до проведения терапии инфицированных гнойных...
Making antibacterial PDT more effective is a task that calls for the development of photosensitizers (PS) based on polycationic synthetic bacteriochlorins and subsequent analysis properties such photosensitizers. This study aimed to explore photophysical nanostructured PS 3-Py4BSHp4Br4, tetracationic amphiphilic derivative bacteriochlorin. The was solubilized in 4% Kolliphor ELP obtain its dispersion. We researched absorption fluorescence spectra intensity profiles, studying concentrations...
The effect of enzymes carbohydrases exopolysaccharide matrix biofilms formed by gram-positive and gram-negative bacteria on abiotic surfaces was studied. ability a mixture carbohydrase (hydrolases lyases) to completely destroy the causing health-associated infections has been confirmed. An optimal possesed high anti-biofilm activity even when employed in relatively small concentrations at brief exposure time.
Polycationic derivatives of synthetic bacteriochlorin with absorption in the near infrared range are promising for creation photosensitizers (PS) antimicrobial photodynamic therapy. In present work, photophysical and antibacterial properties PS based on tetracationic bacteriochlorins: hydrophilic 3-Py4BC(EtBr)4Br4 aqueous solution amphiphilic 3-Py4BCHP4Br4 dispersion Kolliphor ELP were studied. Analysis fluorescence a wide concentrations has demonstrated low aggregation over entire range. A...
ОПТИМИЗАЦИЯ УПРАВЛЕНИЯ КОРПОРАТИВНЫМИ РИСКАМИ ПРЕДПРИЯТИЙ НА ОСНОВЕ ОРГАНИЗАЦИИ ВНУТРЕННЕЙ ПРОВЕРКИ
The article describes a rare clinical case of primary amyloidosis with heart lesion and severe hydropericardium. patient was early considered as manifestation ischemic chronic failure. diagnostic difficulties this are described.
The article describes the rare clinical case of Waldenstr`m's macroglobulinemia in combination with primary amyloidosis which main symptom is polyserositis. diagnostic difficulties this are described.
Федеральное государственное бюджетное образовательное учреждение высшего образования «
The emergence of antibiotic-resistant bacterial strains has recently resulted in a large focus on designing new antimicrobial agents, including those based natural compounds. We have previously synthesized two disubstituted arginine-containing derivatives hemin (HD) (4) and (5) that demonstrated pronounced activity against planktonic cells vitro [1, 2]. These HDs are leading promising for the creation antibacterial agents their basis. This research is aimed at improving synthesis to increase...
ИНТЕГРАЦИЯ ИННОВАЦИОННО-ЦИФРОВЫХ ТЕХНОЛОГИЙ КАК ВЕКТОР РАЗВИТИЯ ФИНАНСОВОГО РЫНКА РОССИИ Сазонов А. А