A5013504340- Lung Cancer Diagnosis and Treatment
- Mesenchymal stem cell research
- Microbial Inactivation Methods
- Esophageal Cancer Research and Treatment
- Neonatal Respiratory Health Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Biomarkers in Disease Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Autopsy Techniques and Outcomes
- Vascular Tumors and Angiosarcomas
- Body Contouring and Surgery
- Erythropoietin and Anemia Treatment
- Gallbladder and Bile Duct Disorders
- Uterine Myomas and Treatments
- Congenital Diaphragmatic Hernia Studies
- Pancreatitis Pathology and Treatment
- Inflammatory Bowel Disease
- Spinal Dysraphism and Malformations
- Parvovirus B19 Infection Studies
- Sarcoidosis and Beryllium Toxicity Research
Federal Medical-Biological Agency
2012-2023
State Research Institute of Highly Pure Biopreparations
2012-2023
Medical Technologies (Czechia)
2021
Ministry of Health of the Russian Federation
2014-2019
Clinical Hospital No. 8
2011-2018
Center for Special Minimally Invasive and Robotic Surgery
2016
Implantation of reporter-labeled tumor cells in an immunocompetent host involves a risk their immune elimination. We have studied this effect mouse model breast cancer after the orthotopic implantation mammary gland adenocarcinoma 4T1 genetically labelled with luciferase (Luc). Mice were implanted and two derivative Luc-expressing clones 4T1luc2 4T1luc2D6 exhibiting equal vitro growth rates. In vivo, daughter clone exhibited nearly same, 4T1luc2D6, lower rate than parental cells. The...
Background. Currently, the patho- and morphogenesis of a new coronavirus infection (COVID-19) is being studied in depth. Conducting comparative analysis morphological changes lungs deceased patients at various time periods after onset first clinical symptoms. Clinical comparisons should help to increase qualified medical care for resuscitation profile reduce hospital mortality. The aim study was formulate working hypothesis conceptual scheme forms development (COVID-19). Methods. An 80 fatal...
We developed recombinant variants of oncolytic vaccinia virus LIVP strain expressing interleukin-15 (IL-15) or its receptor subunit alpha (IL-15Rα) to stimulate IL-15-dependent immune cells. evaluated their activity either alone in combination with each other vitro and vivo using the murine CT26 colon carcinoma 4T1 breast models. demonstrated that admixture these could promote generation IL-15/IL-15Rα complex. In studies indicated cancer cells were more susceptible viruses. showed...
Abstract Background and objective Probe‐based confocal laser endoscopy (p CLE ) allows for real‐time non‐invasive histological imaging via bronchoscopy. Interpreting images correlating with traditional histopathology remains challenging. We performed an ex vivo study to evaluate the correlation between light microscopy findings p of primary lung carcinoma. Methods Post‐lobectomy specimens cancer nodules were examined by . The areas marked brilliant green dye, surrounding tissues stained...
We present a case of 41-year-old patient with invasive pulmonary aspergillosis (IPA) in which probe-based confocal laser endomicroscopy (pCLE) imaging central and distal airways was first performed vivo. pCLE showed the signs complete or partial destruction elastin network alveolar wall fibrillar branching fluorescent structures zone typical IPA changes on HRCT.
Due to recent advances in minimally invasive surgery, there is a new ablation technique – the irre-versible electroporation (IRE), based on effect of electric fields. This report describes firstcase colorectal liver metastases irreversible Russian Federation. early analysis IRE treatment hepatic tumors demonstrates safety for treating malignancies. Larger studies and longer follow-up are necessary determine long-term efficacy.
The Guidelines for comparing the final clinical and pathological / forensic diagnoses are a joint work of working group professional non-profit medical associations – Russian society pathologists Association experts, placed in information system Ministry health Federation «Electronic rubric recommendations’ section «Guidelines». Presents guidelines contain structured on issues between postmortem diagnosis: lists terms definitions, describes rules mapping recommendations determining cause...
Standard approaches to the treatment of chronic post-radiation proctitis are associated with a high risk complications and percentage unsatisfactory results due reduced regenerative potential irradiated tissues. Regenerative surgery techniques using stromal-vascular cell fraction (SVF) based on patient's autologous adipose tissue promising direction for study.
To present treatment strategy for large volumes of injectable non-absorbable 'shell-less' soft tissue fillers (vaseline, synthol, silicone etc.).The authors an experience surgical 8 patients who underwent injections medical vaseline (breast augmentation, n=5) and synthol (muscles enlargement, n=3) review the current literature devoted to this problem.Injection amounts (over 50 ml) into tissues is unacceptable leads numerous complications. Oil-based cannot be removed by minimally invasive...
Background: Transplantation of mesenchymal stem cells (MSCs) is one the most promising directions in treatment idiopathic pulmonary fibrosis. In experimental small animal studies, intravenous and endobronchial (installation) techniques are used for cell preparation delivery, while humans inhalation drugs simplest available method.
 Aim: The aim study was to determine optimal type a nebulizer viability MSCs during nebulization, followed by comparison effects delivery methods standard...
Genital bleeding poses a serious threat to patients with progressive locally advanced malignant tumors. Surgical treatment is often impossible in these patients; therefore, achieve reliable hemostasis, the should undergo embolization of vessels feeding tumor. Good results have been achieved by selective catheterization pelvic arteries using chemoembolization HepaSphere microspheres (Biosphere Medical, France) delivering therapeutic agent Hydrophilicity loaded cytostatics and their biological...
Comparative morphologic assessment of the liver tissue response to preoperative infusion octreotide and prednisolon after major hepatic resection was studied in rats.25 male Wistar rats weighing 230--280 g were used. All underwent 70--80% hepatectomy. The divided into three groups according infusions before hepatectomy: group 1 (n=7) -- received octreotide, 2 (n=8) prednisolone, 3 (n=10) 0.9% saline solution as control. Histologic features remnant evaluated sacrificied 72 hours...
The article describes a rare clinical case of primary amyloidosis with heart lesion and severe hydropericardium. patient was early considered as manifestation ischemic chronic failure. diagnostic difficulties this are described.
We have described the principle and method of confocal laser endomicroscopy using system Cellvizio lung probe Alveoflex (Mauna Kea Technologies, France) to study distal lower respiratory tract in real time. Acynoscopy has been performed 25 patients aged from 24 75 years with different pathology. The problems associated this technology its potential practical applications are discussed.