A5035131979- Sleep and related disorders
- COVID-19 and Mental Health
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Intensive Care Unit Cognitive Disorders
- Perfectionism, Procrastination, Anxiety Studies
- Neuroscience and Neuropharmacology Research
- Work-Family Balance Challenges
- Transcranial Magnetic Stimulation Studies
- Health, psychology, and well-being
- Sleep and Work-Related Fatigue
- Parathyroid Disorders and Treatments
- Fibroblast Growth Factor Research
- Drug Transport and Resistance Mechanisms
- Ergonomics and Musculoskeletal Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Youth Substance Use and School Attendance
- Resilience and Mental Health
- Apelin-related biomedical research
- Anesthesia and Neurotoxicity Research
- Thyroid and Parathyroid Surgery
- Long-Term Effects of COVID-19
- Anesthesia and Sedative Agents
- Electroconvulsive Therapy Studies
National Center of Neurology and Psychiatry
2021-2024
National Institute of Mental Health
2021-2024
Shimane University
2017-2021
Weatherford College
2021
Aim Up to 60% of depressed patients do not obtain sufficient relief from a course antidepressant therapy, and these treatment-resistant major depressive disorder (TRD) are at increased risk for relapse, chronicity, persistent psychosocial impairments, suicide. Probiotics actively participate in treatment neuropsychiatric disorders. However, the role gut microbiota brain disorders depression remains unclear. We performed prospective study evaluate effects Clostridium butyricum MIYAIRI 588...
The authors present the case of a 24-year-old male with treatment-resistant schizophrenia, predominant severe delusion and hallucination, who received bone marrow transplantation (BMT) for acute myeloid leukemia. After BMT, he showed remarkable reduction in psychotic symptoms without administration neuroleptics. He also drastic improvement social functioning. Follow-up evaluations 2 4 years after BMT persistent significant state Recent findings show that major underlying pathogenic mechanism...
Abstract Introduction Recent studies imply that glial activation plays a role in the pathogenesis of psychiatric disorders, such as schizophrenia and major depression. We previously demonstrated Gunn rats with hyperbilirubinemia show congenital gliosis schizophrenia‐like behavior. Methods As it has been suggested depression involves associated neuroinflammation, we examined whether depression‐like behavior using forced swimming test ( FST ) tail suspension TST ). In addition, quantitatively...
Article Abstract Objective: This study aimed to examine the effects of suvorexant on delirium prevention in a real-world setting. Previous studies have demonstrated efficacy for limited randomized clinical trial settings; however, its effectiveness everyday settings remains unknown. Methods: A single-center, retrospective cohort was conducted intensive care unit an academic hospital. Patients (aged ≥ 3 years) admitted from January 2016 December 2018 were eligible if they stayed at least 72...
Abstract Background The average sleep duration of Japanese people is shorter than that from other countries, and bedtime procrastination suspected to be one the factors contributing this issue. This study aimed develop validate version Bedtime Procrastination Scale (BPS-J). Methods BPS-J was developed through procedures including translation back-translation scale, cognitive interviews with 100 participants who reported having experiences being diagnosed insufficient syndrome (ISS) or...
Abstract Introduction: Primary hyperparathyroidism (PHPT) is characterized by hypercalcemia and an elevated level of serum parathyroid hormone (PTH). PHPT presents with a complex set renal, skeletal, neuropsychological symptoms. Parathyroidectomy (PTX) radical treatment that recommended for all physically symptomatic patients PHPT. However, psychiatric symptoms are not considered as indication surgery. There remains important issue from the view perioperative management whether PTX should be...
Table S1 Time course of medications. S2 Diagnostic criteria for dementia with Lewy bodies. S3 symptom examinations. S4 Electroconvulsive therapy settings. Figure Results 123I-ioflupane dopamine transporter single-photon emission computed tomography. The specific binding ratio (SBR blot) was decreased from 2.84 (average, right = 3.05, left 2.64) to 2.56 2.59, 2.56). (a) Two years before presentation at another hospital. (b) At our These results support the diagnosis bodies SBR <3.02 (two...
Health anxiety (HA), defined as excessive worry about having a serious medical condition, may affect preventive behaviors during the coronavirus disease 2019 (COVID-19) pandemic. We examined distinct role of two dimensions HA-perceived likelihood (probability dimension) and awfulness illness (awfulness dimension)-in self-protection, reflected in pandemic.Participants comprised 657 healthcare workers. Data were collected between February 24 26, 2021. The Short Anxiety Inventory determined HA...
Introduction Sleep enhances the antibody response to vaccination, but relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood. Methods In this prospective observational study, we investigated influence of habits on immune acquisition induced by vaccines SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range,...
The authors present the case of a 38-year-old man with schizophrenia and severe insomnia, who attempted suicide twice during oral drug therapy risperidone. patient slept barely 2 or 3 h per night, he frequently took half days off from work due to excessive daytime sleepiness. As maladaptive behavior progressively spent more time lying in bed without sleeping, repeatedly thought about his memories, which were reconstructed hallucinations. His relatives friends noticed that memories not...
Abstract Background This study aimed to evaluate the association of COVID-19 preventive behavior and job-related stress with sleep quality among healthcare workers (HCWs). We conducted a cross-sectional survey using questionnaire at National Center Neurology Psychiatry, Tokyo, Japan. Methods A total 586 participants who completed were eligible for study. The Pittsburgh Sleep Quality Index was used quality. examined level engagement between poor COVID-19-related infection behaviors, such as...
Background: The ventral tegmental area (VTA; a dopaminergic nucleus) plays an important role in the sleep-wake regulation system including orexin system. In addition to neuronal activity, there is increasing evidence for of glial cells (i.e., astrocytes and microglia) these systems. present study examined utility magnetic resonance spectroscopy (MRS) detecting neural and/or changes VTA distinguish responders from non-responders before treatment with receptor antagonist suvorexant. Methods: A...
This study investigated the difference in severity of mental distress and factors contributing to frontline non-frontline healthcare professionals during coronavirus disease (COVID-19) pandemic. A cross-sectional web-based survey medical staff collected by snow-ball sampling was performed Japan October 2020 using Kessler Psychological Distress Scale (K6) as an outcome measure for distress. Originally developed items asking about degree change psychological physical burdens, COVID-19-related...
Fibroblast Growth Factor (FGF) 2 (also referred to as basic FGF) is a multifunctional growth factor that plays pivotal role in the pro-survival, pro-migration and prodifferentiation of neurons.Because alterations FGF2 levels are suggested contribute pathogenesis schizophrenia, we investigated serum Gunn rat, hyperbilirubinemia animal model schizophrenic symptoms.The enzyme-linked immunosorbent assay showed rats were 5.09 ± 0.236 pg/mL, while those normal strain Wistar rats, 11.90 2.142...
Abstract Background : The average sleep duration of Japanese people is shorter than that from other countries, and bedtime procrastination suspected to be one the factors contributing this issue. This study aimed develop validate version Bedtime Procrastination Scale (BPS-J). Methods: BPS-J was developed through procedures including translation back-translation scale, cognitive interviews with 100 participants who reported insufficient syndrome (ISS) using open-ended online questionnaires,...