A5044729595- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Vestibular and auditory disorders
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neural dynamics and brain function
- Animal Vocal Communication and Behavior
- Reproductive System and Pregnancy
- Neonatal Health and Biochemistry
- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Neurological disorders and treatments
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Primate Behavior and Ecology
- Hearing, Cochlea, Tinnitus, Genetics
- Neurotransmitter Receptor Influence on Behavior
- Neurogenesis and neuroplasticity mechanisms
- Public Health and Social Inequalities
- Protein Tyrosine Phosphatases
- Transcranial Magnetic Stimulation Studies
- Phosphodiesterase function and regulation
- Apelin-related biomedical research
Shimane University
2017-2023
Kanazawa Medical University
2023
TiVo (United States)
2023
National Institutes for Quantum Science and Technology
2009-2022
Kitasato University
2005-2017
National Institute of Health Sciences
2016
Imaging Center
2010
Aim Up to 60% of depressed patients do not obtain sufficient relief from a course antidepressant therapy, and these treatment-resistant major depressive disorder (TRD) are at increased risk for relapse, chronicity, persistent psychosocial impairments, suicide. Probiotics actively participate in treatment neuropsychiatric disorders. However, the role gut microbiota brain disorders depression remains unclear. We performed prospective study evaluate effects Clostridium butyricum MIYAIRI 588...
Abstract The rostromedial caudate (rmCD) of primates is thought to contribute reward value processing, but a causal relationship has not been established. Here we use an inhibitory DREADD (Designer Receptor Exclusively Activated by Designer Drug) repeatedly and non-invasively inactivate rmCD macaque monkeys. We inject adeno-associated viral vector expressing the DREADD, hM4Di, into bilaterally. To visualize expression in vivo , develop non-invasive imaging method using positron emission...
Aldolase C (Aldoc, also known as "zebrin II"), a brain type isozyme of glycolysis enzyme, is expressed heterogeneously in subpopulations cerebellar Purkinje cells (PCs) that are arranged longitudinally complex striped pattern the cortex, which closely related to topography input and output axonal projections. Here, we generated knock-in Aldoc-Venus mice Aldoc expression visualized by fluorescent protein, Venus. Since there was no obvious phenotypes general morphology cerebellum mutants, made...
Abstract The cerebellar cortex is organized by transverse foliation and longitudinal compartmentalization. Although the latter, which recognized through molecular expression in subsets of Purkinje cells (PCs), closely related to topographic axonal projection represents functional divisions, details have not been fully clarified mammals other than rodents. Therefore, we examined folial compartmental organization marmoset cerebellum, resembles macaque compared it with that rodent cerebellum...
The authors present the case of a 24-year-old male with treatment-resistant schizophrenia, predominant severe delusion and hallucination, who received bone marrow transplantation (BMT) for acute myeloid leukemia. After BMT, he showed remarkable reduction in psychotic symptoms without administration neuroleptics. He also drastic improvement social functioning. Follow-up evaluations 2 4 years after BMT persistent significant state Recent findings show that major underlying pathogenic mechanism...
Abstract Introduction Recent studies imply that glial activation plays a role in the pathogenesis of psychiatric disorders, such as schizophrenia and major depression. We previously demonstrated Gunn rats with hyperbilirubinemia show congenital gliosis schizophrenia‐like behavior. Methods As it has been suggested depression involves associated neuroinflammation, we examined whether depression‐like behavior using forced swimming test ( FST ) tail suspension TST ). In addition, quantitatively...
Background Positron Emission Tomography (PET) measurement was applied to the brain of common marmoset, a small primate species, treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The marmoset shows prominent Parkinson's disease (PD) signs due dopaminergic neural degeneration. Recently, transgenic (TG) carrying human PD genes is developing. For phenotypic evaluations TG, non-invasive PET considered be substantially significant. As reference control for MPTP-marmoset as an...
Abstract Transversely oriented lobules and longitudinally arrayed stripes of Purkinje cell subsets subdivide the cerebellar cortex into multiple compartments that are involved in diverse functions. In mammalian cerebellum, anterior, posterior lobules, which somatosensorimotor function, show an alternation aldolase C (zebrin II) ‐positive ‐negative stripes, whereas central (lobules VIb–VII crus I), implicated nonmotor functions, a laterally expanded arrangement solely C‐positive stripes. To...
The avian cerebellum is organized into multiple longitudinal stripes defined by expression profiles of aldolase C (zebrin II) in Purkinje cells. relationship between the striped pattern and olivocerebellar projection crucial understanding cerebellar functional compartmentalization. We identified all across lobules with serial section alignment analysis method then looked at this anterograde retrograde labeling axons chick cerebellum. Aldolase were generally consistent continuous from lobule...
Abstract The mechanism by which a lack of thyroid hormone in the early development brain causes permanent mental retardation cretins is currently unknown. On other hand, an abnormality dopamine‐related function believed to underlie some forms illness. In this study, we demonstrate that although activation dopaminergic D 2 ‐like receptor inhibited glutamatergic transmission hippocampal slices normal adult rats, indicating inhibitory action on transmission, it markedly enhanced both mutant...
Epidemiological studies have shown that maternal infection during early pregnancy increases the risk of neurodevelopmental disorders (i.e., schizophrenia or autism) in offspring. Recently, diagnostic/stratification biomarkers for immune activation background patients with been energetically searched patient blood. Here, we report a novel serologic marker candidate found (MIA) rat model. Serum proteome analysis MIA showed immunoglobulin (Ig) light chain is reproducibly augmented. The Ig sera...
Abnormal behaviors of young patients after taking the anti-influenza agent oseltamivir (Tamiflu®, F. Hoffmann-La Roche, Ltd., Basel, Switzerland) have been suspected as neuropsychiatric adverse events (NPAEs). Immune response to viral infection is cause elevation drug concentration in brain adolescents. In present study, effect innate immune activation on uptake [(11)C]oseltamivir was quantitatively evaluated juvenile monkeys.Three 2-year-old monkeys underwent positron emission tomography...
The authors present the case of a 38-year-old man with schizophrenia and severe insomnia, who attempted suicide twice during oral drug therapy risperidone. patient slept barely 2 or 3 h per night, he frequently took half days off from work due to excessive daytime sleepiness. As maladaptive behavior progressively spent more time lying in bed without sleeping, repeatedly thought about his memories, which were reconstructed hallucinations. His relatives friends noticed that memories not...
Fibroblast Growth Factor (FGF) 2 (also referred to as basic FGF) is a multifunctional growth factor that plays pivotal role in the pro-survival, pro-migration and prodifferentiation of neurons.Because alterations FGF2 levels are suggested contribute pathogenesis schizophrenia, we investigated serum Gunn rat, hyperbilirubinemia animal model schizophrenic symptoms.The enzyme-linked immunosorbent assay showed rats were 5.09 ± 0.236 pg/mL, while those normal strain Wistar rats, 11.90 2.142...