A5022092781- Hereditary Neurological Disorders
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Obsessive-Compulsive Spectrum Disorders
- Epilepsy research and treatment
- Genomics and Rare Diseases
- Multiple Sclerosis Research Studies
- Genomic variations and chromosomal abnormalities
- Heart Rate Variability and Autonomic Control
- Lung Cancer Treatments and Mutations
- Pharmacological Effects and Toxicity Studies
- Pain Mechanisms and Treatments
- ATP Synthase and ATPases Research
- Autism Spectrum Disorder Research
- Fetal and Pediatric Neurological Disorders
- Workplace Health and Well-being
- Effects of Radiation Exposure
- Neonatal and Maternal Infections
- Cancer Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Reconstructive Surgery and Microvascular Techniques
- Pericarditis and Cardiac Tamponade
Hospital of Hebei Province
2005-2025
Hebei Medical University
2017-2024
Ningbo University
2024
Henan Psychiatric Hospital
2010
Objective Leigh syndrome (LS) is a heterogeneous neurodegenerative disease and the most frequent pediatric manifestation of mitochondrial disease. In largest patient collection to date, this study aimed provide new insights into clinical genetic spectrum LS, defect‐specific associations, predictors course survival. Methods Clinical, metabolic, neuroimaging, onset, survival data were collected from medical records 209 patients referred Beijing Children's Hospital with symmetrical basal...
This study aimed to obtain a comprehensive understanding of the genetic and phenotypic aspects GABRG2-related epilepsy its prognosis explore potential prospects for personalized medicine.Through multicenter collaboration in China, we analyzed genotype-phenotype correlation antiseizure medication (ASM) patients with epilepsy. The three-dimensional protein structure GABRG2 variant was modeled predict effect missense variants using PyMOL 2.3 software.In 35 variants, 22 were de novo, 18 novel....
Abstract Background To analyze the etiological distribution characteristics of drug-resistant epilepsy (DRE) in children, with aim providing valuable perspectives to enhance clinical practice. Methods In this retrospective study, data were collected on 167 children DRE who hospitalized between January 2020 and December 2022, including gender, age onset, seizure types, video electroencephalogram(VEEG) recordings, neuroimaging, genetic testing results. Based etiology epilepsy, enrolled...
In the present study, sympathetic skin response (SSR) characteristics were explored in children with Guillain-Barré syndrome (GBS) and value of early diagnosis prognostic evaluation GBS complicated by autonomic dysfunction (AD) was evaluated.A total 25 30 healthy controls (HCs) enrolled this prospective study. SSR findings for two groups compared. nerve conduction study (NCS) results compared among patients GBS, differences clinical between abnormal normal analyzed.Within group, six (24%)...
Abstract Objective Serious bacterial infection (SBI) remains an important cause of morbidity and mortality in preterm infants. The objective this study was to evaluate the dynamically increased value red cell distribution width (RDW) diagnosis SBI. Methods This retrospective enrolled 334 infants with birth weight less than 1500 g. initial RDW maximum during hospitalization were extracted from MIMIC-III database (version 1.4). Infants categorized into four groups according baseline ΔRDW (ΔRDW...
Background Progressive cavitating leukoencephalopathy (PCL) is thought to result from mutations in nuclear genes affecting mitochondrial function and energy metabolism. To date, two subunits of complex I, NDUFS1 NDUFV1 , have been reported be related PCL. Methods Patients underwent clinical examinations, brain MRI, skin biopsy muscle biopsy. Whole-genome or whole-exome sequencing was performed on the index patients unrelated families with The effects were examined through complementation...
To study cerebrospinal fluid neurofilament light chain (CSF-NfL) levels as a prognostic biomarker in pediatric Guillain-Barré syndrome (GBS).Prospective enrolling 26 GBS patients and 48 healthy controls (HCs) from neurology units between 2017 to 2021. The CSF-NfL were measured by enzyme-linked immunosorbent assay. children's disability evaluated using Hughes Functional Score (HFS) at nadir, 1 month, 6 months after onset. receiver operating characteristic (ROC) curve derived logistic...
Introduction: Few studies have examined the association between rate of treatment response and outcome pediatric Guillain-Barré syndrome (GBS). Therefore, our study aimed to identify in relation short-term outcomes GBS. Further, we investigated its potential predictive value for prognosis. Methods: Our retrospective included children diagnosed with GBS Pediatric Neurology Department Children's Hospital Hebei Province from 2016 2020. According standard intravenous immunoglobulin (IVIg)...
Abstract Background The morbidity of type 1 diabetes mellitus (T1DM) in children is increasing and diabetic peripheral neuropathy (DPN) one the main microvascular complications T1DM. aim this study was to explore sympathetic skin response (SSR) characteristics with T1DM analyze value early diagnosis follow-up complicated DPN. Methods Our prospective enrolling 85 participants diagnosed 30 healthy controls (HCs) Children’s Hospital Hebei Province from 2017 2020. Compared outcomes SSR nerve...
Abstract Background The application of evoked potentials (EPs) to the diagnosis acute disseminated encephalomyelitis (ADEM ) has not been investigated in detail. aim this study, therefore, was analyze value multimodal EPs early pediatric ADEM. Methods This a retrospective study which we enrolled ADEM patients and controls (Cs) from neurology units between 2017 2021. We measured indices using brainstem auditory (BAEPs), visual (VEPs) somatosensory (SEPs), then analyzed their diagnostic...
To explore the relationship between body mass index (BMI ) and severity of tic disorders (TDs) in children 6-14 years old.
This study aimed to explore the efficacy of clonidine adhesive patch for participants with Tourette syndrome (TS).
Objective About 2 billion people have caries in permanent teeth, and 514 million children primary teeth worldwide. Regional disparities prevalence are evident various areas of China. A comprehensive understanding the status dental its associated risk factors is essential for developing effective health policies economically disadvantaged regions. Thus, this study aims to examine among students aged 12–15 Xide County, a remote mountainous area Design In cross-sectional study, surveys were...
Recurrent bacterial meningitis (RBM) is a rare but life-threatening disease. This study aims to analyze the clinical features, potential causes, and therapeutic outcomes of RBM in children.
Endocapillary hypercellularity (ECHC) is commonly seen in class IV lupus nephritis (LN), the most common and severe LN children. Factors influencing early complete remission (CR) pediatric have been poorly described. We investigated relationship between ECHC levels CR LN.Patients with newly, simultaneously diagnosed systemic erythematosus (SLE) by renal biopsy from 2012 to 2021 were studied. In this retrospective study, two pathologists who blind clinical information reviewed all...
Objective To explore the situation of weary job psychiatric nurses and its relationships to working pressure, coping method social support.Methods Surveys were conducted with Chinese Maslach Burnout Invertory (CMBI), Nurses Job Stressor Inventory (NJSI), Simplified Coping Style Questionnaire(SCSQ) Social Support Scale (SSS) among clinical at Grade-3 Psychosis Special Hospital.Results levels moderate, their main problems emotional exhaustion(27.01 ± 5.66) reduced personal accomplishment(17.07...
Objective To investigate the pathogenic characteristics of viral encephalitis in children living Hebei province. Methods We randomly collected cerebrospinal fluid specimens from a total 399 diagnosed with Children′s Hospital May to December 2017. Real-time fluorescence quantitative PCR and Sanger sequencing were used detect nucleic acids by an automatic laboratory station. Statistical analysis was performed on experimental data using SPSS 21.0 software clinical analyzed. Comparison...