A5019390405- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Particle Detector Development and Performance
- Quantum Chromodynamics and Particle Interactions
- Dark Matter and Cosmic Phenomena
- Computational Physics and Python Applications
- Cosmology and Gravitation Theories
- Neutrino Physics Research
- Distributed and Parallel Computing Systems
- Black Holes and Theoretical Physics
- Astrophysics and Cosmic Phenomena
- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced Data Storage Technologies
- Virology and Viral Diseases
- Atomic and Subatomic Physics Research
- advanced mathematical theories
- Particle Accelerators and Free-Electron Lasers
- Muon and positron interactions and applications
- Nuclear physics research studies
- Geological and Geochemical Analysis
- Superconducting Materials and Applications
- Particle accelerators and beam dynamics
- Syphilis Diagnosis and Treatment
- Geochemistry and Geologic Mapping
Rutherford Appleton Laboratory
2016-2025
Northern Illinois University
2016-2024
Institute of Particle Physics
2024
Atlas Scientific (United States)
2024
A. Alikhanyan National Laboratory
2024
SR Research (Canada)
2024
Federación Española de Enfermedades Raras
2024
The University of Adelaide
2014-2023
University of California, Santa Cruz
2023
Science and Technology Facilities Council
2008-2023
EXO-200 is an experiment designed to search for double beta decay of $^{136}$Xe with a single-phase, liquid xenon detector. It uses active mass 110 kg enriched 80.6% in the isotope 136 ultra-low background time projection chamber capable simultaneous detection ionization and scintillation. This paper describes detector particular attention most innovative aspects design that revolve around reduction backgrounds, efficient use expensive isotopically xenon, optimization energy resolution...
Tissue microarrays assembled from control and multiple sclerosis (MS) brain tissue have been used to assess the expression patterns cellular distribution of two antigens, proinflammatory cytokine osteopontin inducible heat shock protein αΒ‐crystallin, which previously implicated in MS pathogenesis. cores were taken paraffin‐embedded donor blocks containing chronic active or inactive plaques normal‐appearing white matter (NAWM) seven cases, (WM) five cases. Expression both proteins assessed...
Exposure of a human lung epithelial cancer cell‐line to hypo‐osmotic media led marked increase in the rate efflux from cells taurine, non‐essential sulfonic amino acid. The osmotically‐activated taurine was inhibited by range known Cl − channel blockers, most potent which were NPPB and 1,9‐dideoxyforskolin. These reagents similarly effective at inhibiting I , substrate volume‐activated channels. results are consistent with hypothesis that volume‐regulatory release these is mediated channel.
Infection of vascular endothelium plays a central role in the pathogenesis acute measles virus infection outside nervous system (CNS) but has not been described human CNS. An ultrastructural survey was made blood vessels five cases subacute sclerosing panencephalitis (SSPE) to determine whether or cerebral occurred this persistent fatal CNS disease caused by virus. Morbillivirus nucleo‐capsids were found few endothelial cells three necropsy limited tissue available from two biopsies. In...
A case of systemic lupus erythematosus is described which clinically resembled multiple sclerosis and in the lesions were restricted to central nervous system. The necropsy findings vascular thickening necrosis spinal cord a posterior nerve root explain main clinical abnormalities. Clinical signs terminal peritonitis secondary cholecystitis absent or minimised probably because steroid therapy necrosis. Primary demyelination was not demonstrated though electronmicroscopy revealed lattice...
Neurofibrillary tangle formation, a cardinal characteristic of Alzheimer's disease, is also feature several other neurodegenerative disorders, including subacute sclerosing panencephalitis (SSPE). In the present study association measles virus genome with neurofibrillary formation has been studied in five cases SSPE, using situ hybridization (measles genome) and immunocytochemistry (tau, ubiquitin beta/A4 amyloid). two duration disease less than one year, was not observed. However, those...
The fine structure of the CNS in multiple sclerosis. II. Vesicular demyelina‐tion an acute case Tubular vesicular and net‐like dissolution myelin sheaths associated with complete demyelination preservation axons, is described brain, obtained within 4 h death, from a patient who died sclerosis (MS). It was rare, being found only three out twenty‐three blocks examined, seen mainly partially demyelinated margin active plaque white matter. possibility that post‐mortem autolytic changes or...
Measles virus (MV) infection of the human central nervous system (CNS) typically involves widespread neurons. However, little is known about how they become infected, defective arises and accumulates, or spreads among cells CNS. In vitro studies viral interactions with neuronal may contribute to resolution such issues. mixed cultures containing differentiated (hNT2) neuroepithelial cells, immunofluorescence show that neurons, unlike both their NT2 progenitors are not initially susceptible MV...
Abstract Since the 2020 release of $$10 \hbox { fb}^{-1}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:mn>10</mml:mn> <mml:mspace/> <mml:msup> <mml:mtext>fb</mml:mtext> <mml:mo>-</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:math> integrated luminosity proton–proton collision data to public by ATLAS experiment, significant potential for its use youth engagement in physics and citizen science has been present. In particular, this article aims address...
Introduction: Increased blood–brain barrier permeability is a feature of new and expanding inflammatory lesions in multiple sclerosis (MS). The pathological mechanism for this increased has not been demonstrated. Materials methods: Frozen sections from neuropathologically characterized active plaques normal‐appearing white matter (NAWM) areas 13 cases MS were graded according to the relative abundance oil‐red O (ORO)‐positive cells. Using single double immunofluorescence confocal scanning...
During an electron microscopic study of the white matter in multiple sclerosis (MS), spheroidal reticular particles were found both MS and control brains. These have previously been described brain brain-derived cell cultures subacute sclerosing panencephalitis. In cases they interpreted as papovaviruses, but size, morphology distribution are identical to reticulosomes related which occur proteinaceous artefacts a variety tissues subcellular fractions. Inclusions endothelial cytoplasm,...
<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> During 2006 and spring 2007, integration commissioning of trigger data acquisition (TDAQ) equipment in the ATLAS experimental area has progressed. Much work focused on a final prototype setup consisting around eighty computers representing subset full TDAQ system. There have been series technical runs using this setup. Various tests run including those where 6 k Level-1 preselected simulated...
The ATLAS experiment at the Large Hadron Collider (LHC) will face challenge of efficiently selecting interesting candidate events in pp collisions 14 TeV center-of-mass energy, whilst rejecting enormous number background events. High-Level Trigger (HLT=second level trigger and Event Filter), which is a software based need to reduce level-1 output rate ap75 kHz ap200 Hz written out mass storage. In this talk an overview current physics system performance HLT selection for electrons photons...
The ATLAS combined test beam in the second half of 2004 saw first deployment High-Level Trigger (HLT). next steps are on pre-series farms experimental area during 2005, commissioning and cosmics tests with full detector 2006 collisions 2007. This paper reviews experience gained beam, describes current status discusses further enhancements to be made. We address issues related dataflow, integration selection algorithms, testing, software distribution, installation improvements.
The source of gold in the ca. 2.66 Ga Black Reef Formation (BRF) has been investigated and constrained through petrographic, mineralogical, geochemical, high-resolution three-dimensional reflection seismic data combined with drill core underground geological mapping. BRF is a strong marker consists carbonaceous shale, quartz arenite, conglomerate. Gold grade primarily controlled by nature host conglomerates. Most conglomerate occurs native form, its morphology highly heterogeneous. was...
During 2006 and spring 2007, integration commissioning of trigger data acquisition (TDAQ) equipment in the ATLAS experimental area has progressed. Much work focused on a final prototype setup consisting around eighty computers representing subset full TDAQ system. There have been series technical runs using this setup. Various tests run including ones where 6k Level-1 pre-selected simulated proton-proton events processed loop mode through dataflow chains. The system included readout buffers...