A5036453654- Nail Diseases and Treatments
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Plant Pathogens and Fungal Diseases
- Bee Products Chemical Analysis
- Fungal Biology and Applications
- Ethics and bioethics in healthcare
- Health and Medical Education
- Medical and Biological Ozone Research
- Blood disorders and treatments
- Cutaneous lymphoproliferative disorders research
- Milk Quality and Mastitis in Dairy Cows
- Public Health in Brazil
- Pneumocystis jirovecii pneumonia detection and treatment
- Phytochemistry Medicinal Plant Applications
- Infective Endocarditis Diagnosis and Management
- Adrenal and Paraganglionic Tumors
- Pituitary Gland Disorders and Treatments
- Turfgrass Adaptation and Management
- Dermatology and Skin Diseases
- Reproductive Health and Contraception
- Pediatric health and respiratory diseases
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Maternal and Perinatal Health Interventions
Nova Southeastern University
2024
National University of the Northeast
2014-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2010-2020
Centro Científico Tecnológico - Nordeste
2015-2020
Hospital Italiano de Buenos Aires
2012
University of Buenos Aires
2010
Malassezia furfur is lipophilic and lipid-dependent yeast, inhabitant of human skin microbiota associated with several dermal disorders. In recent years, along the advances in nanotechnology incentive to find new antimicrobial drugs, there has been a growing interest utilization nanoparticles for treatment microbial infections. This work aimed study vitro inhibitory activity silver (AgNP) against 41 M. clinical isolates, visualize interaction between AgNP-Malassezia, evaluate synergism...
We studied the in vitro activity of fluconazole (FCZ), ketoconazole (KTZ), miconazole (MCZ), voriconazole (VCZ), itraconazole (ITZ) and amphotericin B (AMB) against three major pathogenic Malassezia species, M. globosa, sympodialis, furfur. Antifungal susceptibilities were determined using broth microdilution method accordance with Clinical Laboratory Standards Institute reference document M27-A3. To support lipid-dependent yeast development, glucose, peptone, ox bile, malt extract,...
Malassezia species are natural inhabitants of the healthy skin. However, under certain conditions, they may cause or exacerbate several skin diseases. The ability this fungus to colonize infect is determined by complex interactions between fungal cell and its virulence factors. This study aims evaluate "in vitro" hydrophobicity levels, adherence on a plastic surface biofilm formation 16 clinical isolates furfur. Cellular (CSH) levels were two-phase system. was tetrazolium salt (XTT)...
The strict nutritional requirements of Malassezia species make it difficult to test the antifungal susceptibility. Treatments chronic and recurrent infections associated with spp. are usually ineffective. objective this study was obtain in vitro susceptibility profile 76 clinical isolates against 16 drugs used for topical or systemic treatment. Isolates were identified by restriction fragment length polymorphism. Minimal inhibitory concentrations (MIC) obtained a modified microdilution...
Summary All Malassezia species are lipophilic; thus, modifications required in susceptibility testing methods to ensure their growth. Antifungal of using agar and broth dilution has been studied. Currently, few tests disc diffusion being performed. The aim was evaluate the vitro yeast against antifungal agents microdilution methods, then compare both methodologies. Fifty isolates were Microdilution method performed as described reference document test tablets discs. To support growth,...
Argentina has two endemic areas of paracoccidioidomycosis (PCM). Bordering Paraguay and Brazil, Northeast (NEA) comprises the area with highest incidence where chronic adult clinical form historically been reported. Juvenile in children adolescents is rare this since only one case was reported last 10 years. Despite this, between 2010 2012, several cases acute/subacute forms aged to 16 (median 12) were detected. In decade, NEA region exposed ecological variations as consequences certain...
The incidence of onychomycosis due to non-dermatophyte moulds (NDM) is increasing. Aspergillus terreus relatively undocumented as an agent this fungal infection. aim work show the prevalence caused by A. and describe its clinical features. Nail samples were collected for microscopic examination culturing in selective media. All cases NDM confirmed a second sample. isolates identified through their morphological characteristics using molecular methods. A total 2485 obtained. Positive cultures...
Abstract The genus Malassezia comprises a heterogeneous group of species that cause similar pathologies. yeasts were considered as the most abundant skin eukaryotes total mycobiome. ability this fungus to colonize or infect is determined by complex interactions between fungal cell and its virulence factors. This study aims evaluate in vitro hydrophobicity levels, adherence capacity on polystyrene surface form biofilm 19 isolates, including M. sympodialis, globosa, slooffiae, from healthy...
Information on paracoccidioidomycosis (PCM) in Argentina is fragmented and has historically been based estimates, supported only by a series of few reported cases. Considering the lack global information, national multicentric study order to carry out more comprehensive analysis was warranted. We present data including demographic clinical aspects historical 466 cases recorded over 10 years (2012-2021). Patients were aged from 1 89 years. The general male: female (M:F) ratio 9.5:1 with...
Abstract The impact of COVID‐19 on paracoccidioidomycosis (PCM) in Argentina and the consequences generated by pandemic are discussed. From 2018 to 3 years after declaration, 285 proven PCM patients were registered. No association between both diseases was documented. frequency decreased extremely low levels 2020. Mandatory social isolation emotional psychological effects under circumstances led delays diagnosis, severe disseminated cases, other challenges for diagnosis subsequent years....
Sporotrichosis is an implantation mycosis caused by Sporothrix spp. It distributed worldwide and can be found in vegetation soil. The most frequent route of infection trauma with elements contaminated fungal propagules. Since domestic cats are the affected animals transmit this to humans, sporotrichosis considered a zoonosis. Clinical presentations include nodular lymphangitis, fixed cutaneous, pulmonary (rare), disseminated (exceptional).To analyze epidemiology Argentina during 2010 2022....
The antifungal susceptibilities of 40 clinical and environmental isolates A. terreus sensu stricto to amphotericin B, terbinafine, itraconazole, voriconazole were determined in accordance with CLSI document M38-A2. All had itraconazole MICs lower than epidemiologic cutoff values, 5% the B higher values. Terbinafine showed lowest MICs. No significant differences found when compared.
Nitration-induced protein damage in the placenta leads to impaired blood flow and deficient feto–placental exchange diabetic pregnancies. This work studied effect of nitric oxide peroxynitrite on Cu/Zn SOD activity rat placentas evaluated whether is nitrated from rats at mid-gestation. Protein nitration was by EIA, inhibition epinephrine auto-oxidation, expression western blot specific immunoprecipitation. study found higher levels (p < 0.001), diminished enhanced 0.01) rats. Placental...
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The ulcerative haemosiderinic dyschromia of chronic venous insufficiency is difficult to heal and presents a high accumulation iron. Lactoferrin, potent natural iron chelator, could help scar this haemosi - derinic dyschromia. objective study was determine whether the topical application liposomal gel with Lactoferrin favors scarring/degradation brown colored spot typical Nine patients severe (CEAP-C6), evolution over 12 months, were included in study. Hemo chromatosis gene mutations...