A5086463901- Extracellular vesicles in disease
- HIV-related health complications and treatments
- HIV Research and Treatment
- Caveolin-1 and cellular processes
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Complement system in diseases
- Galectins and Cancer Biology
- Neutropenia and Cancer Infections
- Curcumin's Biomedical Applications
- Gout, Hyperuricemia, Uric Acid
- Immune Response and Inflammation
- Inflammasome and immune disorders
- Blood disorders and treatments
Université Laval
2020-2025
Centre hospitalier de l'Université Laval
2015-2021
Wilfrid Laurier University
2021
Centre hospitalier universitaire de Québec
2021
HIV-1 infection induces persistent immune system activation despite antiretroviral therapy. New immunomodulatory targets might be required to restore competence. The dendritic cells immunoreceptor (DCIR) can bind and regulate functions extracellular vesicles (EVs) production. EVs have emerged as biomarkers a non-invasive tool monitor progression. In people living with HIV-1, an increase in the size abundance of is associated decline CD4/CD8 T ratio, key marker dysfunction. Analysis host...
The myeloid inhibitory C-type lectin receptor CLEC12A limits neutrophil activation, pro-inflammatory pathways and disease in mouse models of inflammatory arthritis by a molecular mechanism that remains poorly understood. We addressed how CLEC12A-mediated signaling counteracts activating cross-linking human neutrophils. induced its translocation to flotillin-rich membrane domains where ITIM was phosphorylated Src-dependent manner. Phosphoproteomic analysis identified candidate molecules...
Exosomes are extracellular vesicles (EVs) that play a role in intercellular communication. Stimulation of dendritic cells by the HIV-1 virus triggers their release. binds to via cell immunoreceptor (DCIR). This study shows inhibiting binding DCIR significantly decreases exosome release HIV-1-pulsed cells. In addition, from Raji-CD4 expressing stimulated anti-DCIR or is decreased when tyrosine-based inhibition motif (ITIM) signaling mutated. Unlike EVs released Raji-CD4-DCIR after antibody...
Extracellular vesicles (EVs) are intercellular messengers with epigenetic potential since they can shuttle microRNA (miRNA). EVs and miRNA play a role in human immunodeficiency virus (HIV) infection immunopathogenesis. Chronic immune activation systemic inflammation during HIV despite effective antiretroviral therapy (ART) associated non-acquired syndrome (AIDS) comorbidities people living (PLWH). Analysis of plasma their content may be useful as or inflammatory biomarkers PLWH receiving...
Abstract HIV-1 infection induces persistent immune system activation despite antiretroviral therapy. New immunomodulatory targets might be required to restore competence. The dendritic cells immunoreceptor (DCIR) can bind and regulate functions extracellular vesicles (EVs) production. EVs have emerged as biomarkers a non-invasive tool monitor progression. In people living with HIV-1, an increase in the size abundance of is associated decline CD4/CD8 T ratio, key marker dysfunction. Analysis...
Extracellular vesicles (EVs) and their contents (proteins, lipids, messenger RNA, microRNA, DNA) are viewed as intercellular signals, cell-transforming agents, shelters for viruses that allow both diagnostic therapeutic interventions. EVs circulating in the blood of individuals infected with human immunodeficiency virus (HIV-1) may provide insights into pathogenesis, inflammation, disease progression. However, distinguishing plasma membrane from exosomes, exomeres, apoptotic bodies, virions,...
CLEC12A is a myeloid inhibitory receptor that negatively regulates inflammation in mouse models of autoimmune and autoinflammatory arthritis. Reduced expression enhances cell activation knock-out mice with collagen antibody-induced or gout-like Similarly to other C-type lectin receptors, harbours stalk domain between its ligand binding transmembrane domains. While it presumed the cysteines have multimerisation properties, their role and/or signaling remain unknown. We thus used site-directed...
Transfusion of granulocyte concentrates (GC) is an alternative therapy for neutropenic patients with life-threatening infections. While neutrophils are the main source antimicrobial activity, only neutrophil numbers used to certify GCs. The objective this study was thus functionally characterize in GCs prepared by leukapheresis from G-CSF-stimulated donors and compare less characterized prednisone healthy stimulated then G-CSF after a 6-month washout period were analyzed prior leukapheresis,...
Chronic immune activation and systemic inflammation during HIV infection despite effective antiretroviral therapy (ART) is associate with non-AIDS co-morbidities in people living (PLWH). Previous studies have shown that plasma levels of extracellular vesicles (EVs) may be used as or inflammatory biomarkers disease progression. Several focused on microRNA mitochondrial DNA (mtDNA) reached concomitantly cells EVs. We hypothesized large small EVs could contain different amounts mtDNA reflect...