A5087588032- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Viral Infections and Immunology Research
- Leptospirosis research and findings
- Virus-based gene therapy research
- Malaria Research and Control
- Plant Virus Research Studies
- Toxoplasma gondii Research Studies
- Parasitic Infections and Diagnostics
- Virology and Viral Diseases
- Rabies epidemiology and control
- Research on Leishmaniasis Studies
- Viral Infections and Outbreaks Research
- Vector-Borne Animal Diseases
- Animal Behavior and Welfare Studies
- Zoonotic diseases and public health
- Herpesvirus Infections and Treatments
- Trypanosoma species research and implications
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Influenza Virus Research Studies
- Veterinary medicine and infectious diseases
University of Minnesota
2020-2025
University of Minnesota System
2022-2024
Fundação Oswaldo Cruz
2015-2023
Universidade Federal da Bahia
2015-2021
Instituto de Saúde
2015-2021
Hospital Ana Nery
2015-2016
Emory University
2015-2016
Ministério da Saúde
2016
Secretaria Municipal de Saúde
2015-2016
Universidade Estadual Paulista (Unesp)
2011-2014
ABSTRACT Existing genetic classification systems for porcine reproductive and respiratory syndrome virus type 2 (PRRSV-2), such as restriction fragment length polymorphisms sub-lineages, are unreliable indicators of close relatedness or lack sufficient resolution epidemiological monitoring routinely conducted by veterinarians. Here, we outline a fine-scale system PRRSV-2 variants in the United States. Based on >25,000 U.S. open reading frame 5 (ORF5) sequences, sub-lineages were divided...
Background Few studies of dengue have shown group-level associations between demographic, socioeconomic, or geographic characteristics and the spatial distribution within small urban areas. This study aimed to examine whether specific an slum community were associated with risk disease. Methodology/Principal Findings From 01/2009 12/2010, we conducted enhanced, community-based surveillance in only public emergency unit a Salvador, Brazil identify acute febrile illness (AFI) patients...
Abstract Background Since their emergence in the Americas, chikungunya (CHIKV) and Zika (ZIKV) viruses co-circulate with dengue virus (DENV), hampering clinical diagnosis. We investigated epidemiological characteristics of arboviral infections during introduction spread CHIKV ZIKV through northeastern Brazil. Methods Surveillance for diseases among febrile patients was performed at an emergency health unit Salvador, Brazil, between September 2014 July 2016. interviewed to collect data on...
Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness (AEI) attributed to virus, Guillain-Barré syndrome (GBS), microcephaly occurred in 2015. We investigated temporal correlations time lags between these identify common link them by using epidemic curves series cross-correlations. Number GBS cases peaked lag 5-9 weeks from...
Serologic detection of Zika virus (ZIKV) infections is challenging because antigenic similarities among flaviviruses. To evaluate the sensitivity and specificity commercial ZIKV IgM IgG enzyme-linked immunoassay (ELISA) kits. We used sera from febrile patients with RT-PCR-confirmed infection to determine dengue cases blood donors, both which were collected before epidemics in Brazil (2009–2011 2013, respectively) specificity. The IgM-ELISA positivity RT-PCR confirmed was 0.0% (0/14) 12.5%...
Abstract OBJECTIVE Porcine reproductive and respiratory syndrome (PRRS) is a significant disease of swine. The purpose this study was to determine whether application comprehensive, science-based approach breeding herd biosecurity, known as next-generation biosecurity (NGB), could reduce PRRS incidence risk across large commercial production company. ANIMALS Pigs (381,404 sows 76 herds). METHODS From 2009 2020, the annual in sow farms managed by same company averaged 33%, ranging from 20%...
We report an ongoing regional outbreak of emerging porcine reproductive and respiratory syndrome virus (PRRSV2) variant within Lineage 1C affecting 154 breeding grow-finishing sites in the Midwestern U.S. Transmission seemed to have occurred two waves, with first peak weekly cases occurring between October December 2020 second starting April 2021. Most a 120 km radius. Both orf5 whole genome sequencing results suggest that this represents emergence new distinct from what has been previously...
Disease management and epidemiological investigations of porcine reproductive respiratory syndrome virus-type 2 (PRRSV-2) often rely on grouping together highly related sequences. In the USA, last five years have seen a major shift within swine industry when classifying PRRSV-2, beginning to move away from RFLP (restriction fragment length polymorphisms)-typing adopting use phylogenetic lineage-based classification. However, lineages sub-lineages are large genetically diverse, making them...
Porcine Epidemic Diarrhea Virus (PEDV) was introduced in the United States (U.S.) 2013, spreading rapidly and leading to economic losses. Two strains, S-INDEL non-S-INDEL, are present U.S. We analyzed 313 genomes 556 Spike protein sequences generated since its introduction. PEDV case numbers were highest during first two years after introduction (epidemic phase), then declined stabilized following (endemic phase). Sequence availability higher initial epidemic phase. Our results suggest...
Dengue (DENV), Chikungunya (CHIKV), Zika (ZIKV), as well yellow fever (YFV) viruses are transmitted to humans by Aedes spp. females. In Salvador, the largest urban center in north-eastern Brazil, four DENV types have been circulating, and more recently, CHIKV ZIKV also become common. We studied role of storm drains larval development adult resting sites neighbourhoods representing different socioeconomic, infrastructure topographic conditions. A sample 122 study were surveyed twice during a...
Background Chikungunya virus (CHIKV) entered Brazil in 2014, causing a large outbreak Feira de Santana, state of Bahia. Although cases have been recorded Salvador, the capital Bahia, located ~100 km CHIKV transmission has not perceived to occur epidemically, largely contrasting with Zika (ZIKV) and ensuing complications reaching city 2015. Methodology/Principal Findings This study aimed determine intensity Salvador between November 2014 April 2016. Results all laboratory tests performed...
Background Rapid diagnosis tests (RDTs) are easy to carry out, provide fast results, and could potentially guide medical treatment decisions. We investigated the performance of a commercially available RDT, which simultaneously detects non-structural 1 (NS1) dengue virus (DENV) antigen, IgM IgG DENV antibodies, using representative serum samples from individuals in endemic area Salvador, Brazil. Methodology/Principal findings evaluated accuracy SD BIOLINE Dengue Duo RDT (Abbott, Santa Clara,...
Porcine reproductive and respiratory syndrome virus genotype 2 (PRRSV-2) genetic diversity in the U.S. was assessed using a database comprising 10 years’ worth of sequence data obtained from swine production systems routine monitoring outbreak investigations. A total 26,831 ORF5 PRRSV-2 sequences 34 were included this analysis. Within group mean distance (i.e. proportion nucleotide differences within ORF5) per year according to herd type calculated for all sequences. The percent difference...
While the widespread and endemic circulation of porcine reproductive respiratory syndrome virus type 2 (PRRSV-2) causes persistent economic losses to U.S. swine industry, unusual increases severe cases associated with emergence new genetic variants are a major source concern for pork producers. Between 2020 2021, such an event occurred across pig production sites in Midwestern The emerging viral clade is referred as novel sub-lineage 1C (L1C) 1-4-4 variant. This classification based on open...
ObjectivesTo investigate risk factors for persistent arthralgia in patients with chikungunya, and describe its impact on daily activities.MethodsFrom September 2014 to July 2016, a surveillance study enrolled acute febrile illness Salvador, Brazil, detected those chikungunya virus infection using IgM enzyme-linked immunosorbent assay or reverse transcriptase polymerase chain reaction. Telephone follow-ups were performed ascertain the progression of disease.ResultsOf 153 followed cases, 65...
The repeated emergence of new genetic variants PRRSV-2, the virus that causes porcine reproductive and respiratory syndrome (PRRS), reflects its rapid evolution failure previous control efforts. Understanding spatiotemporal heterogeneity in variant spread is critical for future outbreak prevention. Here, we investigate how pace varies across time space, identify origins sub-lineage emergence, map patterns inter-regional PRRSV-2 Lineage 1 (L1)—the current dominant lineage U.S. We performed...