A5103137618- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Finance, Taxation, and Governance
- Cell Adhesion Molecules Research
- TGF-β signaling in diseases
- Angiogenesis and VEGF in Cancer
- Chemokine receptors and signaling
- Social Issues and Policies in Latin America
- Social Sciences and Policies
- Resilience and Mental Health
- Advanced X-ray Imaging Techniques
- Fashion and Cultural Textiles
- Stress and Burnout Research
- Extracellular vesicles in disease
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Advanced Electron Microscopy Techniques and Applications
- Accounting and Financial Management
- Media, Gender, and Advertising
- Kruppel-like factors research
- Single-cell and spatial transcriptomics
- Antioxidant Activity and Oxidative Stress
- Risk Management in Financial Firms
- Educational Technology in Learning
CIC bioGUNE
2024-2025
Universitat de Barcelona
2025
Hospital Clínic de Barcelona
2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2025
Queen Mary University of London
2018-2024
William Harvey Research Institute
2018-2024
Ministerio de Salud - Provincia de Buenos Aires
2024
Universidad Andrés Bello
2008-2023
University of California, San Diego
2021-2023
Millennium Institute on Immunology and Immunotherapy
2016-2020
Neutrophils require directional cues to navigate through the complex structure of venular walls and into inflamed tissues. Here we applied confocal intravital microscopy analyze neutrophil emigration in cytokine-stimulated mouse cremaster muscles. We identified differential non-redundant roles for chemokines CXCL1 CXCL2, governed by their distinct cellular sources. was produced mainly TNF-stimulated endothelial cells (ECs) pericytes supported luminal sub-EC crawling. Conversely, neutrophils...
The migration of neutrophils from the blood circulation to sites infection or injury is a key immune response and requires breaching endothelial cells (ECs) that line inner aspect vessels. Unregulated neutrophil transendothelial cell (TEM) pathogenic, but molecular basis its physiological termination remains unknown. Here, we demonstrated ECs venules in inflamed tissues exhibited robust autophagic was aligned temporally with peak trafficking strictly localized EC contacts. Genetic ablation...
Transforming growth factor beta (TGFβ) and activin A suppress natural killer (NK) cell function proliferation, limiting the efficacy of adoptive NK therapies. Inspired by partial resistance to TGFβ cells with SMAD4 haploinsufficiency, we used CRISPR–Cas9 for knockout in human cells. Here show that SMAD4KO were resistant inhibition, retaining their cytotoxicity, cytokine secretion interleukin-2/interleukin-15-driven proliferation. They showed enhanced tumor penetration control, both as...
The tumour microenvironment (TME) is a highly structured ecosystem that surrounds and plays crucial role in tumorigenesis. As one of the most abundant cell types TME, tumour-associated-macrophages (TAMs) can promote disease progression resistance to therapy. Syndecan-3 (SDC3) cell-surface heparan sulphate proteoglycan expressed by TAMs, although its functional relevance these cells remains unknown. Here, we demonstrated pro-inflammatory cytokines drive expression SDC3 on surface macrophages....
Signal transduction via integrins and G protein–coupled receptors is critical to control cell behavior. These two receptor classes have been traditionally believed trigger distinct independent signaling cascades in response extracellular cues. Here, we report a novel mechanism of integrin that requires activation the trimeric protein Gαi by nonreceptor guanine nucleotide exchange factor (GEF) GIV (also known as Girdin), metastasis-associated protein. We demonstrate enhances...
Finding a marker of neural stem cells remains medical research priority. It was reported that the proteins doublecortin and nucleostemin were related with stem/progenitor in central nervous system. The aim present immunohistochemical study to evaluate expression these their pattern distribution canine brain, including age-related changes, non-nervous tissues. We found had more specific pattern, neurogenesis neuronal migration, while expressed most almost every tissue studied. immunolabeling...
Resumen: El presente trabajo intenta establecer la relación entre el papel que juega conciencia metapragmática en comprensión oral y habilidad para producir textos narrativos escritos.Es, a su vez, parte de un proyecto mayor estudia las habilidades metalingüísticas y/o cognitivas pudieran asociarse al desarrollo del lenguaje no literal edad escolar posibles diferencias lecto-escritura niños niñas con variados niveles figurativo.La se iniciaría alrededor los seis años e involucraría...
A defining feature of an inflammatory reaction is infiltration neutrophils into tissues, a response that requires breaching endothelial cells (ECs) line the lumenal aspect blood vessels. Dysregulated neutrophil trafficking hallmark pathology, but details molecular mechanisms terminate venular walls remain unclear. In this work, we have identified EC autophagy as negative regulator diapedesis in acute physiological inflammation. Specifically, vivo, inflamed ECs upregulate autophagy,...
Correlative light and electron microscopy (CLEM) greatly facilitate capturing the ultrastructure of spatially and/or temporally rare events. Here, we present a protocol for targeting regions interests (ROIs) in tissue endothelial cells (ECs) using X-ray micro-computed tomography (μCT). We describe steps ROI guided by vasculature patterns positions EC nuclei visualized microscopy. The is applicable to thin or translucent tissues that contain defined landmarks visible both For complete details...
To describe the strategy implemented for interruption of 2019-2020 measles outbreak in Metropolitan Area Buenos Aires (Argentina) and application Pan American Health Organization (PAHO) standardized closure criteria to verify viral circulation an adverse setting (the COVID-19 pandemic).
Resumen es: Los medios de representacion son, muchas veces, los que hacen particular una forma hacer arquitectura. En el caso Guillermo Jullian sus tecnicas y ...
El proyecto aborda la aparición de los fashion blogs como nueva forma comunicación digital y el impacto generado en sistema moda, a diez años su momento mayor exposición. Las redes sociales reemplazaron producción estos medios unipersonales que impulsaron una observar consumir moda. trabajo va profundizar motivos dieron lugar surgimiento casos paradigmáticos consolidaron fenómeno evolución hacia un sustentable. Los casos: Chiara Ferragni, Scott Schuman, Emily Weiss, Garance Doré, Leandra...