A5071133249- Viral-associated cancers and disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lymphoma Diagnosis and Treatment
- Respiratory viral infections research
- RNA modifications and cancer
- Head and Neck Cancer Studies
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Histiocytic Disorders and Treatments
- Polyomavirus and related diseases
- Metal complexes synthesis and properties
- bioluminescence and chemiluminescence research
- Ichthyology and Marine Biology
- Plant Molecular Biology Research
- Paleontology and Evolutionary Biology
- Hip disorders and treatments
- Body Contouring and Surgery
- Oil Palm Production and Sustainability
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Facial Nerve Paralysis Treatment and Research
- Plant biochemistry and biosynthesis
- Lower Extremity Biomechanics and Pathologies
- Cytomegalovirus and herpesvirus research
- Cancer Cells and Metastasis
Institute for Medical Research
2016-2025
Universiti Teknologi MARA
2023-2025
Ministry of Health
2019-2025
Hospital Universiti Sains Malaysia
2014
Epstein-Barr virus (EBV) is associated with cancers, including lymphomas and nasopharyngeal carcinoma (NPC). To date, risk variants for NPC were mainly identified from Chinese populations, which dominated the world's total number of cases. Although Southeast Asia (SEA) countries have among top yet intriguingly diverse age-standardized incidence rates across subpopulations, data on EBV SEA remains scarce. In this study, we examined 83 patients different ancestries presence haplotypes Southern...
Nasopharyngeal carcinoma (NPC), a cancer that is etiologically associated with the Epstein-Barr virus (EBV), endemic in Southern China and Southeast Asia. The scarcity of representative NPC cell lines owing to frequent loss EBV episomes following prolonged propagation compromised authenticity previous models underscores critical need for new EBV-positive models. Herein, we describe establishment line, designated NPC268 from primary non-keratinizing, differentiated tissue. can undergo...
Abstract In this study, we first performed whole exome sequencing of DNA from 10 untreated and clinically annotated fresh frozen nasopharyngeal carcinoma (NPC) biopsies matched bloods to identify somatically mutated genes that may be amenable targeted therapeutic strategies. We identified a total 323 mutations which were either non-synonymous (n = 238) or synonymous 85). Furthermore, our analysis revealed in key cancer pathways (DNA repair, cell cycle regulation, apoptosis, immune response,...
Subpopulations of nasopharyngeal carcinoma (NPC) contain cells with differential tumourigenic properties. Our study evaluates the potential CD24, CD44, EpCAM and combination EpCAM/CD44 in NPC. CD44br EpCAMbr enriched for higher S-phase cell content, faster-growing leading to tumours larger volume mitotic figures. Although significantly tumour-initiating (TICs), all could retain self-renewal property at least four generations. Compared CD44 marker alone, EpCAM/CD44dbr did not enhance ability...
Copper(II) ternary complex, [Cu(phen)(C-dmg)(H2O)]NO3 was evaluated against a panel of cell lines, tested for in vivo efficacy nasopharyngeal carcinoma xenograft models as well toxicity NOD scid gamma mice. The Cu(II) complex displayed broad spectrum cytotoxicity multiple cancer types, including lung, colon, central nervous system, melanoma, ovarian, and prostate lines the NCI-60 panel. did not cause significant induction cytochrome P450 (CYP) 3A 1A enzymes but moderately inhibited CYP...
<p>EBV in NPC268 can be induced into lytic phase using various chemical inducers.</p>
The Swiftlet, Aerodramus fuciphagus Thunberg, 1812 (A. fuciphagus) is known for its edible nest building ability. present study was conducted to examine and describe the morphology of lingual apparatus associated structures which contribute ability A. fuciphagus. Gross examination done on upper lower jaw beak prior tissue processing sectioning. Following fixation embedding, cross-sections were made stained with hematoxylineosin (HE) observed under light microscope. Microscopy revealed...
Nasopharyngeal carcinoma (NPC) is an epithelial squamous cell on the mucosal lining of nasopharynx. The etiology NPC remains elusive despite many reported studies. Most studies employ a single platform approach, neglecting cumulative influence both genome and transcriptome toward development. We aim to integrated pathway approach identify dysregulated pathways linked NPC. Our combines imputation GWAS data from Malaysian cohort as well published expression GSE12452 non-NPC nasopharynx...
In vitro modelling of cancer cells is becoming more complex due to prevailing evidence intimate interactions between and their surrounding stroma. A co-culture system which consists than one cell type physiologically relevant thus, could serve as a useful model for various biological studies. An assay that specifically detects the phenotypic changes in multi-cellular lacking nasopharyngeal carcinoma (NPC).Here, we describe luciferase/luciferin (XenoLuc) measure proliferation using two...
<p>NPC268 is capable of anchorage-independent growth and tumorigenic in vivo.</p>
<p>Summary of the NPC268 EBV classification and status high-risk variants</p>
<p>Supplementary Methods</p>
<p>NPC268 is capable of anchorage-independent growth and tumorigenic in vivo.</p>
<p>Summary of the NPC268 EBV classification and status high-risk variants</p>