A5062966951- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- RNA Research and Splicing
- Viral-associated cancers and disorders
- Head and Neck Cancer Studies
- Head and Neck Anomalies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Surgical Oncology
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Genomic variations and chromosomal abnormalities
- Otolaryngology and Infectious Diseases
- Cancer Diagnosis and Treatment
- Tuberculosis Research and Epidemiology
- Cytomegalovirus and herpesvirus research
- Ectopic Pregnancy Diagnosis and Management
- Genomics and Chromatin Dynamics
- Infectious Diseases and Tuberculosis
- Immune Cell Function and Interaction
- Salivary Gland Tumors Diagnosis and Treatment
- Cerebral Venous Sinus Thrombosis
- Oral and Maxillofacial Pathology
Ministry of Health
2022
Hospital Pulau Pinang
2011-2016
RCSI & UCD Malaysia Campus
2016
Guy's and St Thomas' NHS Foundation Trust
2014
Nasopharyngeal carcinoma (NPC) arises from the mucosal epithelium of nasopharynx and is constantly associated with Epstein-Barr virus type 1 (EBV-1) infection. We carried out a genome-wide association study (GWAS) 575,247 autosomal SNPs in 184 NPC patients 236 healthy controls Malaysian Chinese ethnicity. Potential signals were replicated separate cohort 260 245 controls. confirmed HLA-A to strongest signal detected rs3869062 (p = 1.73 × 10(-9)). fine mapping revealed associations amino acid...
Abstract Nasopharyngeal carcinoma (NPC) is a multifactorial and polygenic disease with high incidence in Asian countries. Epstein–Barr virus infection, environmental genetic factors are believed to be involved the tumorigenesis of NPC. The association single nucleotide polymorphisms (SNPs) LPLUNC1 SPLUNC1 genes NPC was investigated by performing two‐stage case control study Malaysian Chinese population. initial screening consisted 81 patients 147 healthy controls while replication 366 340...
Nasopharyngeal carcinoma (NPC) is an epithelial squamous cell on the mucosal lining of nasopharynx. The etiology NPC remains elusive despite many reported studies. Most studies employ a single platform approach, neglecting cumulative influence both genome and transcriptome toward development. We aim to integrated pathway approach identify dysregulated pathways linked NPC. Our combines imputation GWAS data from Malaysian cohort as well published expression GSE12452 non-NPC nasopharynx...
Intracranial complications of chronic otitis media have been on the decline with advent antibiotics. Septic thrombosis sigmoid sinus is rarer compared to commoner such as otogenic brain abscesses and meningitis. This patient presented recurrent infection after left mastoidectomy secondary cholesteatoma a contralateral internal jugular vein parapharyngeal abscess, which was drained. He recovered well postoperatively
Program Description This miniseminar on sialendoscopy will provide the audience with latest developments of sialendoscopy, starting from basics to advanced cases sialadenitis. A complete description actual indications, how best investigate those patients, treat them—under local or general anesthesia, and avoid complications be detailed. All treatment modalities explained videos shown, picture in system, allowing easy comprehension both operative endoscopic field. Results around 100 centers...
Background: Tuberculosis (TB) of the nose and nasopharynx are rare localizations for tuberculosis to manifest. Aim: We hope present a case its presentation. Case presentation: This patient presented with long standing history headache neck pain prior being seen. Imaging showed mass at biopsy con-firmed tuberculosis. Patient was initiated on anti-tuberculosis therapy improvement in her symptoms follow up. Conclusion: A high index suspicion is imperative early diagnosis.
To assess the accuracy of a single Trans Vaginal Scan (TVS) performed by unselected nurses, sonographers and doctors at predicting an Intra Uterine Pregnancy (IUP) its viability. Prospective assessment outcome consecutive “probable early IUPs”, diagnosed on single, first visit TVS without supporting beta-hCG in symptomatic women presenting to tertiary referral EPU. All were rescanned after 10-14 days unless their symptoms worsened. There n = 80 presumed IUPs with mean Gestation Sac Diameter...
<p>Supplemental Figure 1S. Individual Study Results from GWAS Meta-Analysis and Replication Studies for Selected SNPs.</p>
<p>Supplemental Table 1S. Sequenome Primer Design for 43 SNPs included in Our Replications Studies. Supplemental 2S. Results from NPC GWAS Meta-Analysis.</p>
<div>Abstract<p><b>Background:</b> Genetic loci within the major histocompatibility complex (MHC) have been associated with nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer, in several GWAS. Results outside this region varied.</p><p><b>Methods:</b> We conducted a meta-analysis of four NPC GWAS among Chinese individuals (2,152 cases; 3,740 controls). Forty-three noteworthy findings MHC were identified and targeted...
<div>Abstract<p><b>Background:</b> Genetic loci within the major histocompatibility complex (MHC) have been associated with nasopharyngeal carcinoma (NPC), an Epstein-Barr virus (EBV)-associated cancer, in several GWAS. Results outside this region varied.</p><p><b>Methods:</b> We conducted a meta-analysis of four NPC GWAS among Chinese individuals (2,152 cases; 3,740 controls). Forty-three noteworthy findings MHC were identified and targeted...
<p>Supplemental Figure 1S. Individual Study Results from GWAS Meta-Analysis and Replication Studies for Selected SNPs.</p>
<p>Supplemental Table 1S. Sequenome Primer Design for 43 SNPs included in Our Replications Studies. Supplemental 2S. Results from NPC GWAS Meta-Analysis.</p>
None declared. The data that support the findings of this study are available from corresponding author upon reasonable request. Please note: publisher is not responsible for content or functionality any supporting information supplied by authors. Any queries (other than missing content) should be directed to article.