A5029826516- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- IoT and Edge/Fog Computing
- Sports injuries and prevention
- Shoulder Injury and Treatment
- Orthopaedic implants and arthroplasty
- Context-Aware Activity Recognition Systems
- Orthopedic Surgery and Rehabilitation
- Mesenchymal stem cell research
- Periodontal Regeneration and Treatments
- Cloud Computing and Resource Management
- Sports Performance and Training
- Muscle activation and electromyography studies
- Adhesion, Friction, and Surface Interactions
- Mobile Crowdsensing and Crowdsourcing
- Wound Healing and Treatments
- Intelligent Tutoring Systems and Adaptive Learning
- Spine and Intervertebral Disc Pathology
- Innovative Teaching and Learning Methods
- Bone Tissue Engineering Materials
- IoT Networks and Protocols
- Musculoskeletal pain and rehabilitation
- Esophageal and GI Pathology
Universität Ulm
2015-2025
University Hospital Ulm
2011-2024
Helmholtz-Institute Ulm
2014-2023
University Medical Center
2023
Orthopaedic Research
2020
Technical University of Munich
2017-2019
Siemens (Germany)
2016-2018
Klinikum rechts der Isar
2014
University of Freiburg
2009
The Wistar Institute
2004
Damage of cartilage structures in the head and neck region as well orthopedic sites are frequently caused by trauma, tumor resection, or congenital defects. Despite a high demand many clinical fields, until today, no adequate replacement matrix is available for these fields application. Materials that clinically applied joint repair still need optimization due to difficult intraoperative handling risk early mechanical damage. We have developed novel chemical process completely decellularize...
Proper activation of macrophages (Mφ) in the inflammatory phase acute wound healing is essential for physiological tissue repair. However, there a strong indication that robust Mφ responses may be causal fibrotic response always accompanying adult healing. Using complementary approach vitro and vivo studies, we here addressed question whether mesenchymal stem cells (MSCs)-due to their anti-inflammatory properties-would control fibrosis murine model full-thickness skin wounds. We have shown...
Abstract We examined the influence of partial meniscectomy 10 mm width on human cadaveric knee joints, as it is performed during treatment radial tears in posterior horn medial meniscus, maximum contact pressure, area (CA), and meniscal hoop strain lateral compartments. In case 0° 30° flexion angle, 20% 50% did not pressure area. Only 60° flexion, resection increased decreased CA statistically significant. However, 100% significantly meniscectomized compartment all tested positions. No...
One key point in the development of new bioimplant matrices for reconstruction and replacement cartilage defects is to provide an adequate microenvironment ensure chondrocyte migration de novo synthesis cartilage-specific extracellular matrix (ECM). A recently developed decellularization sterilization process maintains three-dimensional (3D) collagen structure native septal while increasing porosity, which considered be crucial tissue engineering. Human primary nasal chondrocytes were...
The increasing number of students in computer science courses leads to high efforts manual assessment exercises. Existing systems are not designed for exercises with immediate feedback large classes. In this paper, we present an AuTomated assEssment Management System interactive learning.
In this study, we report the beneficial effects of a newly identified dermal cell subpopulation expressing ATP-binding cassette subfamily B member 5 (ABCB5) for therapy nonhealing wounds. Local administration ABCB5
Fog Computing, Augmented Reality (AR) and Blockchain are technologies that have been receiving more attention in recent years. Computing for on-site data analysis as a decentralized framework used to establish security trust. AR enables new interactive scenarios with devices the industrial environment provides user interfaces had previously lacked one. The combination of these an opens up possibilities opportunities. We present IIoT Bazaar, marketplace edge applications relies on create...
Devices used in fog and edge computing are heterogeneous distributed. These environments unpredictable their applications becoming more complex. This leads to challenges regarding deployment management of applications. It is important ensure that quality service, availability, reliability real-time characteristics guaranteed during take advantage computing. In this paper, we present Fogernetes, a platform enables with specific requirements on devices different capabilities. Fogernetes allows...
Supply chain networks in the automotive industry deal with numerous participants and parts on multiple tiers that are spread across several geographical locations. Due to their inherent complexity high focus data protection a competitive original equipment manufacturer market, supply chains often lack transparency responsiveness. However, legal authorities such as Federal Motor Transport Authority of Germany or National Highway Traffic Safety Administration USA require end-to-end...
An exact understanding of the interplay between articulating tissues knee joint in relation to osteoarthritis (OA)-related degeneration process is considerable interest. Therefore, aim present study was characterize biomechanical properties mildly and severely degenerated human joints, including their menisci tibial femoral articular cartilage (AC) surfaces. A spatial mapping surfaces 12 cadaveric joints assessed using a multiaxial mechanical testing machine. To do so, indentation stress...
Purpose To investigate the 3D displacement and local strain of medial meniscus its attachments under compressive loading. Materials Methods Magnetic resonance imaging (MRI) scans six porcine knee joints were performed unloaded loaded conditions (100% 200% body weight [BW]). Volumes registered to obtain a field attachments, which divided into five anatomic compartments. Finally, displacements center mass each compartment analyzed. Results The significantly displaced by up 2.6 ± 1.2 mm ( P...
Osteoarthritis (OA) is characterized by an imbalance in cartilage and underlying subchondral bone homeostasis. We hypothesized that signals from the may modulate production of matrix components, alter chondrogenic differentiation potential cocultured marrow-derived mesenchymal stem cells (BMSC) induce a phenotypic shift differentiated OA chondrocytes. established novel coculture model between BMSC, mixed cultures (BMSC chondrocytes) chondrocytes embedded fibrin gel with normal explants (OAB...
ObjectiveBecause the literature relating to influence of degeneration on viscoelasticity and tissue composition human lateral menisci remains contradictory or completely lacking, aim this study was fill these gaps by comprehensively characterising biomechanical properties with regard degree degeneration.DesignMeniscal from 24 patients undergoing a total knee replacement collected each region classified according Pauli et al. For characterisation, compression tensile tests were performed....
Multiple camera systems are widely used for 3D-motion analysis. Due to increasing accuracies these gained interest in biomechanical research areas, where high precision measurements desirable. In the current study different measurement were compared regarding their accuracy.Translational and rotational accuracy as well zero offset of seven performed using two reference devices evaluation algorithms. All same room with constant temperature at laboratory. Equal positions measured according a...
Abstract Articular cartilage regeneration is a challenge in tissue engineering. Although diverse materials have been developed for this purpose, remains suboptimal. The integration of nanomaterials into 3D network holds great potential the improvement key mechanical properties, particularly important osteochondral replacement scaffolds and even to function as carriers disease‐modifying drugs or other regulatory signals. In study, simple yet effective cell‐free nanoenabled Col‐PLA scaffold...
In the present study, we established a novel in vitro coculture model to evaluate influence of osteoarthritis (OA) cartilage explants on composition newly produced matrix and chondrogenic differentiation human bone marrow-derived mesenchymal stem cells (BMSCs) phenotype OA chondrocytes. addition, included "tri-culture" model, whereby mixture BMSCs chondrocytes was cultured surface explants. Gene expression analysis, protein glycosaminoglycan (GAG) assays, dot-blot, immunofluorescence,...
In large classes, there is typically a clear separation between content delivery in lectures on the one hand and deepening practical exercises other hand. This temporal spatial has several disadvantages. particular, it separates students' hearing about new concept from being able to actually practice apply it, which may decrease knowledge retention.
MOOCs differ from traditional university courses: instructors do not know the learners who have a diverse background and cannot talk to them in person due worldwide distribution. This has decisive influence on interactivity of teaching learning success online courses. While typical exercises such as multiple choice quizzes are interactive, they only stimulate basic cognitive skills reflect software engineering working practices programming or testing. However, application knowledge practical...
The purpose of this study was to investigate the potential a doubled semitendinosus (ST) and single gracilis tendon (GT) lateral meniscus autograft restore knee joint kinematics tibiofemoral contact after total meniscectomy (LMM).Fourteen human joints were tested intact, LMM ST GT treatment under an axial load 200 N during full range motion (0°-120°) four randomised loading situations: without external moments, rotation, valgus stress combination rotation using simulator. Non-parametric...