A5003940523- Spectroscopy and Laser Applications
- Photonic and Optical Devices
- Analytical Chemistry and Sensors
- Spectroscopy Techniques in Biomedical and Chemical Research
- Water Quality Monitoring and Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Spectroscopy and Chemometric Analyses
- Infection Control and Ventilation
- Osteoarthritis Treatment and Mechanisms
- Advanced Chemical Sensor Technologies
- Musculoskeletal pain and rehabilitation
- Spine and Intervertebral Disc Pathology
- Laser Design and Applications
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Infrared Thermography in Medicine
- Advanced Fiber Laser Technologies
- Mechanical and Optical Resonators
- Plasmonic and Surface Plasmon Research
- Infective Endocarditis Diagnosis and Management
- Atmospheric and Environmental Gas Dynamics
- Semiconductor Lasers and Optical Devices
- Soft Robotics and Applications
- Urban Stormwater Management Solutions
- Medical Imaging and Analysis
Freie Universität Berlin
2024
Max Delbrück Center
2024
Charité - Universitätsmedizin Berlin
2024
Humboldt-Universität zu Berlin
2024
Universität Ulm
2016-2022
Hahn-Schickard-Gesellschaft für angewandte Forschung
2021-2022
Uppsala University
2018
University of Tübingen
2017
Septodont (France)
2012
Infrared spectroscopy in the 3-20 μm spectral window has evolved from a routine laboratory technique into state-of-the-art and sensing tool by benefitting recent progress increasingly sophisticated spectra acquisition techniques advanced materials for generating, guiding, detecting mid-infrared (MIR) radiation. Today, MIR provides molecular information with trace to ultratrace sensitivity, fast data rates, high resolution catering demanding applications bioanalytics, example, improved...
We report the development of plasmonic chip-based systems comprising self-assembled gold nanostars at silicon substrates that enable concomitantly enhanced Raman (surface spectroscopy; SERS) and mid-infrared infrared reflection or absorption SEIRA) spectral signatures.
The performance and versatility of GaAs/AlGaAs thin-film waveguide technology in combination with quantum cascade lasers for mid-infrared spectroscopy comparison to conventional FTIR is presented. Infrared radiation provided by a laser (QCL) spectrometer comprising four tunable QCLs providing wavelength range 5–11 μm (1925−885 cm–1) within single collimated beam. Epitaxially grown GaAs slab waveguides serve as optical transducer tailored evanescent field absorption analysis. A modular...
ObjectiveBecause the literature relating to influence of degeneration on viscoelasticity and tissue composition human lateral menisci remains contradictory or completely lacking, aim this study was fill these gaps by comprehensively characterising biomechanical properties with regard degree degeneration.DesignMeniscal from 24 patients undergoing a total knee replacement collected each region classified according Pauli et al. For characterisation, compression tensile tests were performed....
Recently emerging broadly tunable quantum cascade lasers (tQCL) emitting in the mid-infrared (MIR) are a versatile alternative to well established thermal emitters combination with interferometers as applied Fourier transform infrared (FTIR) spectroscopy.
Mid-infrared (MIR) sensors based on attenuated total reflection (ATR) spectroscopy provide robust, rapid and sensitive platforms for the detection of low levels organic molecules pollutants.
Gas analysis via mid-infrared (MIR) spectroscopic techniques has gained significance due to its inherent molecular selectivity and sensitivity probing pronounced vibrational, rotational, roto-vibrational modes. In addition, MIR gas sensors are suitable for real-time monitoring in a wide variety of sensing scenarios. Our research team recently introduced so-called substrate-integrated hollow waveguides (iHWGs) fabricated by precision milling, which have been demonstrated be useful online...
The analytical performance of micromachined μ-groove silicon attenuated total reflection (ATR) elements has been evaluated in a comparison Fourier-transform infrared (FTIR) and quantum cascade laser (QCL) spectroscopy operating at mid-infrared (MIR) wavelengths. μ-Groove ATR are highly efficient waveguides fabricated wafer scale such low cost that they may be considered consumable for single-time-use, e.g., medical application scenarios. Herein, exemplary analytes haven used reliably...
Micro-ring resonators with a decoupling waveguide have been manufactured from GaAs/Al0.2Ga0.8As, accommodating mid-infrared wavelengths, and were characterized via thermal tuning. A Q-factor of 1900, full width at half maximum 8 °C, free spectral range 18 °C achieved. The low indicates comparatively high coupling efficiency the input into waveguide. micro-ring shown herein are suitable structures for advanced chem/bio sensing strategies resonant-cavity enhancement. In addition, they offer...
Compact sensors for the detection of biomolecules were developed by combining plasmonic nanostructures with gradient-index lenses.
Photonic design and optimization of thin-film polycrystalline diamond waveguides are shown, serving as advanced evanescent field transducers in the mid-infrared fingerprint regime (2000–909 cm–1; 5–11 μm). Design constraints inherent to optical/system considerations material were implemented a finite element method (FEM)-based simulation that allowed three-dimensional modeling overall structure. Thus, lateral mode confinement, attenuation direction radiation propagation, physical resilience...
Abstract Objective The first international consensus criteria for optic neuritis (ICON) were published in 2022. We applied these to a prospective, global observational study of acute (ON). Methods included 160 patients with first‐ever ON suggestive demyelinating CNS disease from the Acute Optic Neuritis Network (ACON). 2022 ICON all participants and subsequently adjusted by replacing missing relative afferent pupillary defect (RAPD) or dyschromatopsia if magnetic resonance imaging pathology...
To evaluate the feasibility of Fourier transform infrared attenuated total reflectance (FTIR-ATR) spectroscopy to detect cartilage degradation due osteoarthritis and validate methodology with osteochondral human samples for future development towards clinical use.Cylindrical (d = 4 mm) (n 349) were prepared from nine cadavers measured FTIR-ATR spectroscopy. Afterwards, assessed Osteoarthritis Research Society International (OARSI) histopathology assessment system divided into two groups:...
An innovative mid-infrared spectroscopic sensor system based on quantum cascade lasers has been developed. The combines the versatility of substrate-integrated hollow waveguides (IHWGs) with robustness attenuated total reflection (ATR) crystals employed as internal for evanescent field sensing. IHWGs are highly reflective metal structures that propagate infrared (IR) radiation and were used light pipes coupling into ATR waveguide. combined IHWG-ATR device designed such utmost stability...
Abstract During recent years, mid-infrared (MIR) spectroscopy has matured into a versatile and powerful sensing tool for wide variety of analytical tasks. Attenuated total reflection (ATR) techniques have gained increased interest due to their potential perform non-destructive tasks close real time. In ATR, the essential component is sampling interface, i.e., ATR waveguide its material properties interfacing sample with evanescent field ensuring efficient photon-molecule interaction. Gallium...
Abstract The ongoing COVID-19 pandemic represents a considerable risk for the general public and especially health care workers. To avoid an overloading of system to control transmission chains, development rapid cost-effective techniques allowing reliable diagnosis individuals with acute respiratory infections are crucial. Uniquely, present study focuses on direct face mask sampling approach, as worn (i.e., used) disposable masks contain exogenous environmental constituents, well...
Given the exquisite capability of direct, non-destructive label-free sensing molecular transitions, IR spectroscopy has become a ubiquitous and versatile analytical tool. application scenarios range from industrial manufacturing processes, surveillance tasks environmental monitoring to elaborate evaluation (bio)medical samples. recent developments in associated fields, spectroscopic devices increasingly evolve into reliable robust tools for quality control purposes, rapid analysis within...
Microfabricated diamond waveguides, between 5 and 20 μm thick, manufactured by chemical vapor deposition of diamond, followed standard lithographic techniques inductively coupled plasma etching are used as bio-chemical sensors in the mid infrared domain: 5-11 μm. Infrared light, emitted from a broadly tunable quantum cascade laser with wavelength resolution smaller than nm, is through waveguides for attenuated total reflection spectroscopy. The expected advantages these high sensitivity due...
Laser light sources are routinely applied building blocks in optical sensor technologies. While lasers emitting at a precisely defined wavelength within narrow emission bands, chem/bio-sensing applications frequently demand multi-wavelength illumination for addressing series of species. Instead using broadband radiation sources, it is viable strategy to efficiently combine the beams emitted from different maintain spectral brightness and yet cover extended regimes. In this study,...
Combination of FTIR spectroscopy with fiber optics provides a powerful diagnostic tool for diagnosing human diseases, including osteoarthritis. To detect cartilage degradation, an arthroscopic probe based on polycrystalline fibers was developed and evaluated equine specimen. The hook shape allows reaching significant portion the articular surface; flat tip ensures avoidance tissue destruction. Efficient QCL-coupling stable transmission PIR under bending assembling effective thin arthroscopy...
Collagen cross-links contribute to the mechanical resilience of intervertebral disc (IVD). UVA-light-activated riboflavin-induced collagen crosslinking (UVA-CXL) is a well-established and effective ophthalmological intervention that increases rigidity collagen-rich corneal matrix in Keratoconus. This study explores feasibility, safety efficacy translating this reinforcing IVD.Annulus fibrosus (AF) cells were isolated from bovine IVDs treated with different combinations riboflavin (RF)...