A5032174647- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Liver Disease Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Autoimmune and Inflammatory Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Liver Diseases and Immunity
- COVID-19 and healthcare impacts
- Immunodeficiency and Autoimmune Disorders
- Gastrointestinal disorders and treatments
- Helicobacter pylori-related gastroenterology studies
- Pediatric Hepatobiliary Diseases and Treatments
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Autoimmune and Inflammatory Disorders Research
- Biosimilars and Bioanalytical Methods
- Amoebic Infections and Treatments
- Tuberculosis Research and Epidemiology
- Cardiac, Anesthesia and Surgical Outcomes
- Gastrointestinal Tumor Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Acute Kidney Injury Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Tallaght University Hospital
2008-2025
University of Milan
2023
ASST Fatebenefratelli Sacco
2023
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie
2022
NIHR Birmingham Biomedical Research Centre
2021
Azienda Ospedaliera San Gerardo
2019-2021
University of Milano-Bicocca
2019-2021
University of Birmingham
2021
Yorkshire Cancer Research
2021
Urology Foundation
2021
•Under real-world conditions, OCA was effective in ~43% of patients who were non-responders to UDCA, according Poise criteria.•Patients with cirrhosis showed lower efficacy (29.5%), mainly attributed reduced tolerability and higher discontinuation rate.•Patients overlap AIH-PBC a comparable pure PBC, ALT reduction at 6 months.•Most PBC are still need additional therapy if aiming normalise liver biochemistry. Background & aimsObeticholic acid (OCA) is the second-line treatment approved for...
Abstract Background Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterised by chronic mucosal inflammation the colon. Patients with IBD may have higher fatigue scores compared to non-IBD controls [1] up 41% reporting as debilitating symptom [2]. Previous clinical trials demonstrated anti-inflammatory properties Bifidobacterium longum 35624® in people UC [3], and increased energy/vitality 1714® healthy population [4]. However, studies this dual combination strains...
Abstract Background Ulcerative colitis (UC) is a form of Inflammatory Bowel Disease (IBD) characterised by chronic mucosal inflammation the colon. It has been shown that fatigue in patients with ulcerative particularly burdensome symptom[1]. Studies have IBD higher scores than non-IBD control groups[1]. In UC, alterations microbiome understood to be contributing factor pathophysiology disease and found reduced compared healthy controls[2-4]. The aim this study therefore evaluate effects...
Budesonide is a synthetic steroid of the glucocorticoid family with high topical antiinflammatory activity. Enteric-coated formulations resist gastric-acid degradation, delivering active drug to small intestine and proximal colon. has first-pass metabolism minimal systemic absorption. It therefore felt cause fewer side effects than traditional glucocorticosteroids be generally well tolerated. The aim this paper examine utility medication in frequently encountered gastrointestinal conditions:...
Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which metabolized EPHX2 (epoxide hydrolase 2, alias soluble epoxide or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity Map (CMAP) approach, we identified an inverse-correlation between exemplar inhibitor (EPHX2i) compound response and inflammatory bowel disease patient-derived signature. To validate the gene-disease link, tested...
Background:Studies have demonstrated the benefit of dose optimisation in setting secondary loss response to infliximab inflammatory bowel disease.
Abstract Background While progress has been made in the identification of Crohn’s disease (CD) susceptibility loci, efforts to identify a genetic basis for progression have less fruitful. The specific aim this study was build upon major advances IBD by applying genome-wide technologies toward predicting CD. Methods cases (n = 1495) from 3 centers were reviewed experienced physicians. Clinical and demographic details collected, focusing on time first progression. Genome-wide association (GWA)...
Several symptoms impair the quality of life (QoL) patients with primary biliary cholangitis (PBC). They are reported to vary significantly in different countries. Aim our study was explore whether there is a geographical clustering that accounts for PBC.Data analysed from four cohorts PBC UK, Spain, Japan and Italy using PBC-27 scale.Overall, 569 were identified, including 515 females (90.5%) mean age 61 years. The analysis provided evidence strict factorial invariance scale, robust...
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Ileal intubation is being increasingly performed at colonoscopy and has in turn lead to an recognized subgroup of patients—those with mild terminal ileal inflammation, entity that we have coined isolated active ileitis (IAI). The aims this study were define the natural history IAI determine if shares a similar genetic serologic profile Crohn's disease (CD). Patients identified from our institution's histopathology endoscopy databases. Cases attended for repeat blood analyzed expression...
A hyper-responsive adaptive immunologic response to a variety of microbial antigens has been described in Crohn's disease (CD) patients and elevated levels number antibodies have identified the sera CD patients. To date, serological profiles an Irish population not characterized.The aim this study is determine profile with CD. Second, we assess correlation, if any, between phenotype within cohort.A total 179 consecutive adults attending specialist inflammatory bowel clinic at university...
Video capsule endoscopy is an invaluable tool for examining the small bowel. It non-invasive and generally well tolerated, however its role in assessment of severity extent bowel Crohn's disease has not, to date, been adequately evaluated.All endoscopies performed over a two year period tertiary referral centre subjects with known or suspected were reviewed.Twenty-six studies total included. These 15 cases disease, 5 3 endoscopically diagnosed non-specific terminal ileal inflammation finally...
Eosinophilic oesophagitis is a recently recognized oesophageal disorder characterized by combination of clinical and endoscopic features as well the histological finding on biopsy greater than 15 eosinophils per high powered field. Recent reports suggest eosinophilic increasing in incidence this increase cannot be fully explained increased recognition disorder. The aim retrospective study was to assess within catchment area tertiary referral hospital southwest Dublin, Ireland.The...
Incomplete excretion rates are problematic for colon capsule endoscopy (CCE). Widely available booster regimens suboptimal. Recently published data on one day preparation CCE protocol using castor oil appeared effective.To assess the impact of adding to a standard split-dose (2-d) in an unselected Western patient cohort.All patients aged 18 or more referred our unit over 5-mo period were prospectively recruited. Controls retrospectively identified from database. All received split bowel with...
Spirochaetes are well known causative agents of diarrhoea in veterinary medicine. However, there is no agreement as to whether or not they have any clinical significance humans.To assess the symptoms associated with intestinal spirochaetosis, their response treatment and natural history untreated cases.A retrospective review all cases spirochaetosis identified within an eight year period a single university teaching hospital was performed. A chart follow up telephone interview performed...
Abstract Background and study aims Colon capsule endoscopy (CCE) is a recommended viable alternative to colonoscopy for colonic visualisation in variety of clinical settings with proven efficacy polyp detection, surveillance, screening Inflammatory Bowel Disease (IBD) assessment. CCE an unselected average risk symptomatic cohort has yet be established. The aim this was determine the feasibility imaging assessment patients as without additional biomarker Patients methods This prospective,...
Increased familiarity with capsule endoscopy (CE) has been associated a growing demand for urgent inpatient procedures. Limited data exists comparing the effect of admission status on colon (CCE) and pan-intestinal (PIC) performance. We aimed to compare quality versus outpatient CCE PIC studies.A retrospective nested case-control study. Patients were identified from CE database. PillCam Colon 2 Capsules standard bowel preparation booster regimen used in all studies. Basic demographics key...
Background Increased TI intubation at colonoscopy had led to increased identification of mild ileal inflammation. Patients with co-called Isolated Active ileitis (IAI) have inflammation, no chronicity on histology, and do not fulfil criteria for a diagnosis Crohn’s Disease (CD). Causes include CD, NSAID use or infection. The natural history IAI has remained unclear. Aim Long term follow up cohort patients diagnosed as IAI, assess evolution persistent Self-Limiting Ileitis (SLI). Method were...
Penetrating Crohn’s disease (CD) can lead to the development of abdominal phlegmon and abscesses. Phlegmon formation be addressed with antibiotic therapy, percutaneous drainage, or surgical resection. The role anti-tumor necrosis factor (anti-TNF) treatment in this scenario is less well established. In particular, it not clear how anti-TNF therapy affects need for A retrospective chart review was conducted all CD patients over age 18 presenting abscess between years 2000 2017 at Mount Sinai...