A5036969174- Cephalopods and Marine Biology
- Neuroendocrine regulation and behavior
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- DNA Repair Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Prostate Cancer Treatment and Research
- CRISPR and Genetic Engineering
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Ubiquitin and proteasome pathways
- Cancer Cells and Metastasis
- Liver physiology and pathology
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Genetics, Aging, and Longevity in Model Organisms
- RNA Research and Splicing
- Histone Deacetylase Inhibitors Research
- Renal and related cancers
- Echinoderm biology and ecology
New York University Abu Dhabi
2020-2024
New York University
2022
University of Insubria
2016-2018
Few animal groups can claim the level of wonder that cephalopods instill in minds researchers and general public. Much cephalopod biology, however, remains unexplored: largest invertebrate brain, difficult husbandry conditions, complex (meta-)genomes, among many other things, have hindered progress addressing key questions. However, recent technological advancements sequencing, imaging, genetic manipulation opened new avenues for exploring biology these extraordinary animals. The molecular...
Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic acid sensing pathways evolved to detect pathogens, but also serve cull cells with inappropriate TE activation as TEs be viral mimetics. Epigenetic silencing is mediated in part by DNA methylation, it not clear if or the immune system contribute damage caused loss methylation. Here, we provide mechanistic insight into observation an activated interferon response liver zebrafish larvae deletion critical...
Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these not well studied in non-model organisms. Unique features of cephalopods make them attractive for investigating behavioral, sensory, developmental, and regenerative processes, recent studies have elucidated novel genome organization gene transposon regulation animals. However, it is known how epigenetics regulates interesting cephalopod features. We combined bioinformatic molecular analysis Octopus...
Abstract We hypothesized that the highly controlled pattern of gene expression is essential for liver regeneration encoded by an epigenetic code set in quiescent hepatocytes. Here we report and transcriptomic profiling regenerating mouse livers define chromatin states dictate transposon repression. integrate ATACseq DNA methylation with ChIPseq histone marks H3K4me3, H3K27me3 H3K9me3 variant H2AZ to identify 6 distinct functional characteristics. show genes involved proliferation reside...
Restoring homeostasis following proteostatic stress hinges on a stress-specific transcriptional signature. How these signatures are regulated is unknown. We use functional genomics to uncover how activating transcription factor 6 (ATF6), central in the unfolded protein response, regulates its target genes response toxicant induced and physiological liver. identified 652 conserved putative ATF6 targets (CPATs), which functioned metabolism, development proteostasis. Strikingly, Atf6 activation...
Acquisition of cellular fate during development is initiated and maintained by well-coordinated patterns gene expression that are dictated the epigenetic landscape genome organization in nucleus. While marks mediate developmental organogenesis have been well studied, less known about how influence nuclear development. This study examines relationship between structure, chromatin accessibility, DNA methylation, hepatic outgrowth zebrafish larvae. We investigate these features using mutants...
Summary Tumor heterogeneity is the substrate for tumor evolution and linchpin of treatment resistance. Cancer cell largely attributed to distinct genetic changes within each population. However, widespread epigenome repatterning that characterizes most cancers also highly heterogenous tumors could generate cells with diverse identities malignant features. We show high levels epigenetic regulator oncogene, UHRF1, in zebrafish hepatocytes rapidly induced methylome disordering, loss...
ABSTRACT Proteostatic stress initiates a transcriptional response that is unique to the condition, yet regulatory mechanisms underlying distinct gene expression patterns observed in stressed cells remains unknown. Using functional genomic approach, we investigated how activating transcription factor 6 (ATF6), key unfolded protein (UPR), regulates target genes. We first designed computational strategy define Atf6 genes based on evolutionary conservation of predicted ATF6 binding promoters,...
Abstract Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet little is known about epigenome in non-model organisms. Unique features of cephalopods make them attractive for investigating behavioral, sensory, developmental and regenerative processes, but using molecular approaches such studies hindered by lack knowledge genome organization gene regulation these animals. We combined bioinformatic analysis Octopus bimaculoides to identify expression signatures 12 adult...